Module 2.6 Flashcards
Mitosis
AA type of cell division wher eone cell splits into two .
-Mitosis is part of a much longer porcess called the cell cycle .
cell cycle
-the whole cell cycle takes a long time
-the duration of the cell cycle depends ont he type of cell (mammalian cell 24 hours)
-Some cells take months
-Some cels even exist the cell cycle either temporarily or permanently .
Cell cycle conists of two main parts
-The Mphase (or mitotic phase ) is when mitosis takes place and cells divide into two .
-However , the Mphse is actuallhy a relatively short period within the whole cell cycle .
Most of the cell cycle is called interphase .
during interphase , the cell ma apper to be relatively inactive , but actually lots of different processes are happening .
-dURING INTERPHSE , THE CELL IS CARRYING OUT THE FUNCTIONS OF THAT PARTICULAR CELL YPE ,.(iNTESTICAL EPITHELIAL CELLS ) - ARE ABSORBING NUTRIENTS from the small intenstine .
the interphase can be divided into three main phases .
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G1 PHASE (1st stage )
-during g1 phase - the cell replicaites organelles such as mitochondria
-Replicating organelles require a great deal of proteins .
-So durinng G1 , a high level of transcrption and translation take place .
(Loooked a in protein synthesis )
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G1 phase prt two
-During g1 , the size of the cell also increases .
-This ensures that when the cell duvudes , the two daughter ells are the correct size.
second phase of interpahse (second stage )
-SPHASE
Next the cell passes into the s or synthesisi phase .
-During the s phse all of the chromosomes are replicated + to do this , cells need to synthesise a great deal of DNA .
last phase of interphase is the G2 PHASE
now cell enters GN phase .
-During GN , the cellreplaces the energy stores sued during the s phase
-cell contitnues to carry out transcription and transaltion .
-If any of the chromosmes have been damaged , then theya re REPAIRED during gn .
-jUST LIKE g1 PHAE , cells continue to GROW .
Once the cell has fnished G2 phase , it now enters the M or mitotic phase
Mitotic pahse can be divided into two prts .
MITOSIS - chromosomes separate into two sepearae nueclei .
-CYTOKENSISI - cell divideds into TWO .
sometimes , cellcs can exit the cell cycle , if this happeens , then scientists say tht the cell is in the G0 phase .
cell enters g0 phase for three reasons.
reason 1
fully differentiated cells can enter g0 and stay there for the rest of their lives (adult neurones )
reason 2
overtime , DNA can be damaged .
At a certain point , the cell will no longer be bale to divide .
-Scienitsts call this senescent cells , At this stage , the cell enters G0 permanantly.
reason 3
lsdtly , cell enters g0 temporary for example b memory cells
-thee cells an the be triggered to renter the cellc ycle during n inreaction .
-the cell cycle is very tightly regulated .
at certain key points in th cell cycle , the cell chekcs that the cell cycle should continue , Scienitsts call these CHECKPOINTS .
-At any point , if a cell fails a checkpoint , it iwll leave the cell cycle and enter g0.
there are three checkpoints
first checkpoint
first checkpoint
before the spahse ,t he cell must pass thorugh the g1 checkpoint .
-Here the cell checks it has gorwn into the correct size and also checks for DNA damage .
secodn checkpoint
if the cell satisidies the g1 checkpoint , then it passes into the s pashe and carries out DNA repliation .
-Thr next check point is AT THE END OF GN and before cell passes into the mitotic pahse .
-Again at the G2 checkpoint , cell checks for DNA damage and if the cell has grown to the correct size .
third checkpoint
if this checkpoint is passed , then cell enters the mitotic pahse .
-Final checkpoint is called he SPINDLE CHECKPOINT .
-Checks that the chromosmes are assembled correectly on the mtioti spindle .
-If this is the case , then he cellc ompeltes mtiosis and proceeds thorugh cytokenesis .
chromosomes
a cell that is aout to udnergo mitosis
cell only contains two pairs of chrosmomes (just to make diagram more simplfied)
Most organsisms contain lot mroe (23 pirs )
Long chrosmomes are shown in green
and short pair is hsown in ellow
cheomosmoes that are in pairs are xcalled diploid cells .
in cell divisionby mitosis , we staert with one diploid cell and end up with two .
-Two identical diploid cells like this .
-so cell division by mitosis takes place whn we ant idneical copies of cell 9e,g whena n organsism grows and repairs itself )
-Mitosis also used in a sexul reporduction
-mitosis par of the cell cyce.
-cell cycle has 2 pairs m phase nd interphase
-during interpHAW , RHW Cell increases its energy stores and grows in size .
-cell also replicates its organelles nd copies its DNa .
in the miotitic pahse , the cell crries out two processes
nueclues divides into two daughter nueclei (mitosis )
2. cell divides intwo d=two daughter cells each with a nucleus (cytokensis (
-JEY ; mitsosis is specifically refers to the division of thenueclues
division of CELL is cytokenesis .
both cytokensis and mitosis take plce in m phase
CCloser look at key event in itnerphase
KEY ; during interphase , we CANNOT SEE chromosmes in the neucles .
-The chormosmes are there but not visile as DISTINC TSTRUCUTRES .
-Instead we see dark mateiral called CHROMATIN .
-In croamtin , the chormomsoes jage a loose , open strucutre and hti smeans the DNA is ccesile for transcirption dd REPLICTION +TRANSCIRPTION
DNA in a chromosome
KEY ; Dna is a single long moelucl of DN .
KEY ; during interpahse , chormosmoes replictae like this
-now we hve two dienticl moelcule of dna .
-Scienitsts now cllt hese sister chormatids and the chromatids are joined t the centromere .