Module 3

Question 1

Innate or Adaptive:
Provides constant and relatively rapid protection

Answer 1

Innate Immunity

Question 2

Innate or Adaptive:
Previous exposure not required to be activated

Answer 2

Innate Immunity

Question 3

Innate or Adaptive:
Cells does not respond to specific viral antigens

Answer 3

Innate Immunity

Question 4

Innate or Adaptive:
Cells are activated by the presence of the virus

Answer 4

Innate Immunity

Question 5

Innate or Adaptive:
Develops only after exposure to a virus

Answer 5

Adaptive Immunity

Question 6

Innate or Adaptive:
Specific to that particular pathogen and close relatives

Answer 6

Adaptive Immunity

Question 7

Innate or Adaptive:
Involves cell and antibody mediated effector mechanism

Answer 7

Adaptive Immunity

Question 8

Innate or Adaptive:
Includes the T and B lymphocytes

Answer 8

Adaptive Immunity

Question 9

Innate or Adaptive:
Exhibits a memory property

Answer 9

Adaptive Immunity

Question 10

Innate or Adaptive:
Quickly reactivated after re-exposure

Answer 10

Adaptive Immunity

Question 11

Innate or Adaptive:
Includes the production of cytokines

Answer 11

Innate Immunity

Question 12

These are cytokines made by lymphocytes

Answer 12

Interleukins

Question 13

These are key family of cytokines

Answer 13

Interferons

Question 14

Are key elements of antiviral resistance at the cellular level.

Answer 14

Interferons

Question 15

These protein hormones bind to the IFN-α receptor

Answer 15

Type I interferon (IFN)/ IFN-α.

Question 16

Activates the signaling cascade that results to induction of the interferon response genes in cells

Answer 16

Type I interferon (IFN)/ IFN-α.

Question 17

Cytokine central to both innate and adaptive immunity.

Answer 17

Type II interferon or IFN- γ

Question 18

Also known as Immune interferon

Answer 18

Type II interferon or IFN- γ

Question 19

Defines multiple subtypes of T Lymphocytes.

Answer 19

Type II interferon

Question 20

Designated as IFN-λ (lambda)

Answer 20

Type III

Question 21

IFN- γ is what type of Interferon

Answer 21

Type II

Question 22

Type I Interferon are activated via cel/lular receptors called

Answer 22

Pattern Recognition Receptors

Question 23

These detects pathogen-associated molecules patterns (PAMPs) specific to different classes of viruses

Answer 23

Pattern Recognition Receptors (TLRs)

Question 24

TRUE or FALSE:
Binding of PAMPs to PRRs stimulates the transcription of numerous genes encoding proteins involved in innate and immune responses including interferon.

Answer 24

TRUE

Question 25

Toll-like receptors that bind ssRNA, detect RNA virus infections

Answer 25

TLR7 & TLR8

Question 26

Toll-like receptors that detects dsRNA

Answer 26

TLR3

Question 27

Type I interferon released from virus-infected cells or activated innate response cells stimulates adjacent cells via what?

Answer 27

INFAR (Interferon-alpha/beta receptor)

Question 28

These specialized lymphocytes lack an antigen-specific receptor

Answer 28

Natural Killer Cells

Question 29

Natural Killer Cells can kill virus-infected cells, tumor cells and other cells they detect to be in a state of what?

Answer 29

State of Stress

Question 30

These expresses an extensive complex of receptors that recognize PAMPs

Answer 30

Natural Killer CElls

Question 31

TRUE or FALSE: Natural Killer cells binds to MHCII complex proteins

Answer 31

FALSE

Question 32

TRUE or FALSE: Common effect of virus infection is reduced expression of class II MHC on surface of infected cells

Answer 32

FALSE: Class I MHC

Question 33

TRUE or FALSE: NK cells kill virus-infected cells by inducing apoptosis

Answer 33

TRUE

Question 34

Natural Killer Cells are very efficient at production and secretion of what type of Interferon?

Answer 34

Type II interferon

Question 35

They are critical to the initiation of the adaptive immune response but also central to innate immunity.

Answer 35

Dendritic Cells

Question 36

They express a high density of Class II MHC proteins

Answer 36

Dendritic Cells

Question 37

They are highly phagocytic in the naive state

Answer 37

Dendritic Cells

Question 38

TRUE or FALSE: Dendritic cells can also respond to stimulation by PAMPs by secreting Type I Interferon

Answer 38

TRUE

Question 39

What are the Dendritic Cells of the skin?

Answer 39

Langerhans Cells

Question 40

What immunity is mediated by antibodies secreted by terminally differentiated B lymphocytes

Answer 40

Humoral Immunity

Question 41

Differentiated B lymphocytes are called?

Answer 41

Plasma Cells

Question 42

What immunity is driven by alpha and beta T cell receptor expressing lymphocytes

Answer 42

Cell-mediated Immunity

Question 43

TRUE or FALSE: Classical Dendritic cells are professional antigen presenting cells

Answer 43

TRUE

Question 44

This type of immunity is mediated by antibodies

Answer 44

Humoral Immunity

Question 45

Antibody found primarily in blood; first antibodies produced.

Answer 45

IgM

Question 46

Principal class of Antibody in blood and extracellular fluid.

Answer 46

IgG

Question 47

The main antibody secretion in the respiratory, genital and the GIT

Answer 47

IgA

Question 48

Antibody that are very low concentration in the blood and ECF

Answer 48

IgE

Question 49

Antibody that mediates allergic reactions

Answer 49

IgE

Question 50

This antibody is expressed almost exclusively as a cell surface molecule by naive B cells

Answer 50

IgD