Module 4 Part 1 Venous Thromboembolism Flashcards
(45 cards)
what is the principle indication for antiplatelet drugs?
prevention of thrombosis in arteries
what are the 2 main adverse effects of aspirin?
- Even in low doses, aspirin inc. risk for GI bleed and hemorrhagic stroke
- Enteric-coated or buffered aspirin may not reduce risk of GI bleeding
should dosing for aspirin be high or low?
should be low when preventing cardiovascular events.
-Doses higher offer no greater benefit but do inc. risk for bleeding and stroke
what dose of aspirin is used for initial treatment of MI? why?
higher dose of 325mg/day is used for initial treatment to establish full anti platelet effects rapidly and then return to 81mg/day for maintenance dosing
what is hemostasis and what are the two stages it occurs in?
process by which bleeding is stopped.
- formation of a platelet plug
- reinforcement of the plug with fibrin (coagulation). Both are set in motion by blood vessel injury
how does your body protect against widespread coagulation?
-body must inactivate any clotting factors that stray from site of vessel injury (inactivation is done with antithrombin)
what is necessary in order for an injured BV to heal?
removal of a clot
define thrombosis
blood clot formed within a BV or within the heart
what are the 3 major drug groups for thromboembolic disorders?
- anticoagulants
2. antiplatelets, thrombolytic drugs
what makes up a venous thromboembolism (VTE)?
deep vein thrombosis (DVT) and pulmonary embolism (PE) collectively make up VTE
do DVT and PE’s usually show mnfts?
no, they are often clinically silent!
what are the 3 factors (virchow’s triad) of VTE?
- stasis of blood (venous stasis)
- vessel wall injury
- altered blood coagulation
formation of thrombus usually accompanies… ???
PHLEBITIS (inflammation of vein walls)
venous thrombosis usually occurs in what veins?
veins of lower extremities, (therefore upper extremity thrombosis is not as common)
although upper extremity venous thrombosis is less common, when would you see this in patients?
would see in patients with IV catheters or for those who have underlying disease that causes hypercoagulability
risk factors of endothelial damage for DVT and PE? (7)
• Trauma • Surgery • Pacing wires • Central venous catheters • Dialysis access catheters • Local vein damage -Repetitive motion injury
risk factors of venous stasis for DVT and PE? (5)
• Bed rest or immobilization • Obesity • History of varicosities • Spinal chord injury -Age greater than 65yrs
what are preventative measures for VTE? (4)
• Increasing mobility (getting them walking)
• Compression stockings
• Intermittent pneumatic compression devices (once these come off, then PAT can be done)
-Prophylactic Anticoagulant Therapy (PAT)
what are objectives of treatment for DVT?
prevent the thrombus from growing and fragmenting (thus risking PE), recurrent thromboemboli, and prothrombotic syndrome
what two types of drug therapy can you combine to possibly eliminate DVT
-combining anticoagulation therapy with thrombolytic therapy
This may eliminate venous obstruction, maintain venous patency, and prevent postthrombotic syndrome (caused by early removal of the thrombus)
how can you provide a patient with comfort with DVT?
- warm, moist packs applied to affected extremity reduce discomfort
- pt encouraged to walk once anticoagulation therapy has been initiated
- bed exercises (repetitive dorsiflexion of the foot) are recommended
whats the worst thing that could happen with VTE (aka DVT)?
breaking of clots (emboli) that can go anywhere in body (usually go to lungs)
TRUE OR FALSE: Veins DO NOT have valves
FALSE
veins HAVE valves, arteries DO NOT
S+S of VTE
• Swelling
• Pain
• Cool or warm to touch
Can be non-specific… hard to diagnose
