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NUTR 202 > Module 9: Vitamins > Flashcards

Module 9: Vitamins Flashcards

1
Q

what type of nutrients are vitamins

A

micronutrients

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2
Q

are vitamins organic or inorganic

A

organic (contain carbon)

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3
Q

how do vitamins assist is providing energy

A

through metabolic processes

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4
Q

which vitamins are fat soluble

A

K, A, D, E

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5
Q

describe fat soluble vitamins storage in the body (time, amount, place)

A
  • stored for long periods of time, not required in diet every day
  • stored in large quantities
  • stored in liver and fat cells
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6
Q

describe water soluble vitamins storage in the body (time, amount)

A
  • stored for short periods of time, required in diet everyday
    -not generally stored in large quantities
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7
Q

are fat soluble vitamins more likely to be deficient or toxic

A

toxic

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8
Q

are water soluble vitamins more likely to be deficient or toxic

A

deficient

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9
Q

what are the three chemical forms of vitamin A

A
  • retinol
  • retinal
  • retinoic acid
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10
Q

which form of vitamin A is the most active

A

retinol

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11
Q

what is a precursor to vitamin A that is found in the pigment of carrots

A

beta carotene

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12
Q

what are the functions of vitamin A

A
  • integrity of epithelial cells
  • bone growth
  • cell membrane stability
  • gene regulation
  • vision
  • immune function
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13
Q

what does RAE stand for

A

retinol activity equivalent

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14
Q

who needs an increased amount of vitamin A and why

A
  • women who are pregnant and breastfeeding
  • needed for epithelial tissue growth of babies
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15
Q

define preformed vitamin A

A

ready to use, not needed to be converted

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16
Q

what are food sources of preformed vitamin A

A
  • animal-based foods
  • fortified foods
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17
Q

define provitamin A

A
  • must be converted to active form of vitamin A as needed
  • ex: beta carotene
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18
Q

what are food sources of provitamin A

A

plant-based foods

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19
Q

what are the effects of early stages of deficiency of vitamin A on vision and can it be reversed

A
  • night blindness
  • reversible
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20
Q

what are effects of short term vitamin A deficiency on the cornea

A

cornea becomes dry and damaged

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21
Q

what are effects of long term vitamin A deficiency on the cornea

A

xerophthalmia: permanent loss of vision

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22
Q

describe how vitamin A assists immune function

A
  • disease resistance, particularly for children
  • production of white blood cells
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23
Q

describe how vitamin A assists in the integrity of epithelial cells

A
  • epithelial tissue in the skin, lungs, and lining of the GI tract
  • vitamin A aids in proliferation of cells
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24
Q

which vitamin is linked with cell differentiation (development of specialized cells)

A

vitamin A

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25
describe how vitamin A assists with gene regulation
- role in turning genes on and off - indirect role in the regulation of metabolism
26
describe how vitamin A assists with bone metabolism
stimulates osteoclasts that break down the inner part of bone
27
why should children 1-3 get less vitamin A than older people
- vitamin A assists in bone metabolism - too much vitamin A can lead to poor growth in children
28
what is the difference between osteoclasts and osteoblasts
- osteoclasts: break down bone - osteoblasts: build up bone
29
where is vitamin A stored
- fat tissue - liver
30
what are symptoms of vitamin A toxicity
- liver damage - birth defects
31
is provitamin A toxic
no
32
what can beta carotene help prevent
- heart disease - cancer
33
why are smoker encouraged to avoid vitamin A
- increased risk of lung cancer in smokers - vitamin A can cause proliferation of cells which can lead to cancer in smokers
34
should the general public take beta carotene supplements
no
35
what is the scientific name for vitamin D
cholecalciferol
36
what is vitamin D classified as
- vitamin - hormone - steroid
37
what is the function of vitamin D
- regulation of calcium metabolism: - producing calbindin - stimulating kidneys to conserve calcium - stimulating calcium release from bone to blood
38
what does vitamin D stimulate the small intestines to produce and what does it do
- calbindin - calcium-binding protein - increases calcium absorption
39
how does vitamin D affect the kidneys
- stimulates kidneys to conserve calcium - decreases urinary calcium excretion
40
why are bones broken down for calcium
broken down when calcium is needed for other functions throughout the body
41
how often do you have a completely new skeleton
every 10 years
42
what happens to the recommendation for amount of vitamin D as we age and why
- requirement increases as we age - less ability to convert vitamin D into its active form - less likelihood of adequate sunlight exposure
43
what food sources do we get a majority of vitamin D from
fortified foods
44
is vitamin D essential or nonessential and why
- non essential - body can make it through exposure to sunlight
45
how does the body make vitamin D from sunlight
- cholesterol in skin combine with UV rays from the sun - cholesterol enters bloodstream - converted into precursor of vitamin D - sent to liver where it is converted to another inactive form - goes to kidneys - converted to active form D3
46
what factors influence vitamin D synthesis
- distance from equator - amount of clothing coverage - sun block use - cloud cover - skin color - age
47
describe rickets
- caused by vitamin D deficiency in children - softening and deformity of long bones, bowing of legs - inability to deposit calcium in newly formed bone - malformation of skull, rib cage, and ends of long bones
48
describe osteomalacia
- caused by vitamin D deficiency in adults - softening of bone caused by decalcification - similar to rickets in children
49
is vitamin D toxicity common
no
50
what could cause vitamin D toxicity
overuse of supplements
51
what are symptoms of vitamin D toxicity
- nausea, vomiting, diarrhea - calcification of soft tissue
52
why do ethnic populations have higher rates of vitamin D insufficiency
- less conversion of cholesterol to vitamin D due to melanocytes in skin - consume less milk due to culture, many are lactose intolerant
53
what are chronic diseases linked with vitamin D insufficiency
- diabetes - hypertension
54
where is vitamin E primarily found
cell membranes
55
what is the group of compounds that makes up vitamin E called
tocopherols
56
what are the 4 types of tocopherols
- alpha - beta - gamma - delta
57
what are the functions of vitamin E
- antioxidant: neutralizes free radicals - enhances immune function - required for nerve cell development
58
what is the number 1 antioxidant
vitamin E
59
define free redicals
- unstable compounds with unpaired electrons - attack other molecules with electrons which damages cell membranes, proteins, enzymes, and DNA
60
how does vitamin E act as an antioxidant
neutralizes free radical by donating electrons
61
describe how vitamin C and E work together to neutralize free radicals
- vitamin C gives an electron to vitamin E which gives the electron to the free radical - vitamin C becomes radicalized, but its water soluble so it will be eliminated quickly
62
where can free radicals come from
- UV rays (sun) - pollution - stress - poor diet - small amounts form normal metabolism
63
why are smokers discouraged from taking vitamin E supplements
increase incidence of brain hemorrhage
64
what vitamins are smokers discouraged from taking
vitamins A and E
65
is vitamin E deficieny common or rare
rare
66
who is most likely to experience vitamin E deficiency
- premature infants - those with insufficient stores
67
what condition results from vitamin E deficiency
anemia
68
why does vitamin E deficiency cause anemia
red blood cells become fragile and malformed and eventually rupture
69
what are symptoms of vitamin E deficiency
- loss of muscle coordination and reflexes - muscle weakness - reproductive failure - impaired vision
70
what are signs of vitamin E toxicity
- headache, nausea, blurred vision - reduced sexual function in men - accelerated signs of aging - inflammation of the mouth - chapped lips - fatigue - GI disturbances - muscle weakness - increased bleeding
71
what is the primary function of vitamin K
blood clotting
72
how does vitamin K promote blood clotting
activates the protein fibrin which is required to form blood clots
73
what is a secondary function of vitamin K
synthesis of the bone protein osteocalcin
74
who requires more vitamin K: men or women
men
75
do childbearing women require more vitamin K than non-childbearing women
no
76
what population is at the highest risk of vitamin K deficiency
newborns
77
why are newborns at a higher risk for vitamin K deficiency
- sterile GI tract at birth: E coli produce 80% of vitamin K - breast milk is poor source
78
what vitamin is given to babies at birth
vitamin K
79
what is a potential risk factor for vitamin K deficiency
prolonged antibiotic use
80
what is the most significant source of vitamin K for humans
E coli in large intestine (80%)
81
what vitamins are water soluble
- vitamin C - B vitamins
82
which vitamins are less toxic: fat or water soluble, and why
- water-soluble are less toxic - eliminated more often
83
what is the scientific name for vitamin C
ascorbic acid
84
describe scurvy
- disease causing death of sailors in 1800s - caused by vitamin C deficiency
85
symptoms of scurvy
- bleeding gums - tooth loss - poor wound healing - small hemorrhages on skin
86
what are the functions of vitamin C
- antioxidant - synthesis of collagen - facilitates iron absorption in GI tract
87
what vitamin in second to vitamin E as an antioxidant
vitamin C
88
what body system do antioxidants support
immune system
89
define collagen
- protein that forms connective tissues of tendons, bone, teeth, and skin - high strength - highly recycled in the body
90
what are the functions of collagen
- wound healing - maintenance of blood vessel structure
91
who has an increased need for vitamin C and why
- smokers - protects body against damaging compounds in tobacco smoke
92
how much more vitamin C should smokers get than non-smokers
additional 35 mg per day
93
what is the best known source of vitamin C
orange juice
94
what affects the levels of vitamin C in food
- food preparation - vitamin C is vulnerable to heat and oxygen
95
why does vitamin C deficiency cause anemia
- vitamin C needed for iron absorption - less vitamin C = less iron absorption = anemia
96
what are signs of vitamin C deficiency
- bleeding gums - loss of appetite - pinpoint hemorrhaging - impaired growth - weakness - scorbutic rosary in infants
97
how much vitamin C is toxic
2 g per day
98
what often causes vitamin C toxicity
supplementing at greater than 1g per day
99
list all B vitamins
- B1: thiamin - B2: riboflavin - B3: niacin - B5: pantothenic acid - B6: pyridoxine - B7: biotin - B9: folate - B12: cobalamine
100
why is there no vitamin B4
- existed at one time - lost status as vitamin\ - compound now known as adenine (one of the nitrogenous bases)
101
what is a common function of all B vitamins
coenzymes or cofactors in energy metabolism
102
what is the scientific name for vitamin B1
thiamin
103
what was the first individual B vitamin identified
thiamin (B1)
104
what are the functions of vitamin B1 (thiamin)
- part of coenzyme thiamin pyrophosphate (TPP) - assists in function of nerve and muscle cell activity
105
what is the active form of vitamin B1 (thiamin)
thiamin pyrophosphate (TPP)
106
what does thiamin pyrophosphate (TPP) do
- assists in metabolism of carbohydrates and some amino acids - conversion of pyruvate to acetyl CoA - used in Kreb's cycle
107
is there an upper limit for vitamin B1 (thiamin)
no
108
what part of the grain kernel has the most B12 vitamins
germ
109
who often experiences thiamin (vitamin B1) deficiency
- malnourished individuals - alcoholics
110
define beriberi
- vitamin B1 (thiamin) deficiency - heart becomes enlarged, fluid accumulates beneath skin, and muscles weaken/atrophy - wet and dry beriberi
111
what type of beriberi primarily affects the cardiovascular system
wet beriberi
112
what type of beriberi primarily affects the nervous system
dry beriberi
113
define wernicke-karsakoff syndrome
- severe thiamin (vitamin B1) deficiency in alcoholics - causes ataxia, memory loss, and muscle atrophy
114
what is the scientific name for vitamin B2
riboflavin
115
what are the two activated forms of vitamin B2 (riboflavin)
- flavin mononucleotide (FMN) - flavin adenine dinucleotide (FAD)
116
what is the main function of vitamin B2 (riboflavin)
activated forms (FMN and FAD) used as electron shuttles in energy metabolism
117
where is flavin mononucleotide (FMN) in the electron transport chain
protein complex 1
118
where is flavin adenine dinucleotide (FAD) in the electron transport chain
protein complex 2
119
what can destroy vitamin B2 (riboflavin)
ultraviolet light and irradiation
120
what does vitamin B2 (riboflavin) deficiency often occur in conjunction with
other water-soluble vitamin deficiencies
121
what are the symptoms of vitamin B2 (riboflavin) deficiency
inflammation of membranes (sore throat, cracked mouth, swollen tongue)
122
what is the scientific name for vitamin B3
niacin
123
what are the 2 chemical forms of vitamin B3 (niacin)
- nicotinamide - nicotinic acid
124
what are the functions of vitamin B3 (niacin)
- release energy from macronutrients through coenzymes in metabolic pathways - synthesis of fatty acids
125
what are the two niacin-containing coenzymes used in metabolic pathways
- nicotinamide adenine dinucleotide (NAD) - nicotinamide adenine dinucleotide phosphate (NADP)
126
what is the upper limit for vitamin B3 (niacin)
35 mg per day
127
why is vitamin B3 (niacin) often found in preworkout
causes flushing and tingling which can make some people ready to workout
128
what are sources of vitamin B3 (niacin)
animal proteins
129
what essential amino acids can be used to synthesis vitamin B3 (niacin) in the body
tryptophan
130
what condition is caused by vitamin B3 (niacin) deficiency
pellagra
131
what are the symptoms of pellagra
- vitamin B3 (niacin) deficiency - 4D's: diarrhea, dermatitis, dementia, death
132
what vitamin deficiency was common in southeastern US during the early 1900s due a diet poor in it
vitamin B3 (niacin)
133
does vitamin B3 (niacin) have toxicity symptoms
yes
134
how do people often get vitamin B3 (niacin) toxicity
overconsumption of supplements or fortified foods
135
what are symptoms of vitamin B3 (niacin) toxicity
- flushing: redness of face, arms, and legs - tingling sensations - liver injury
136
what are high doses of nicotinic acid prescribed for
cholesterol reduction
137
what is the scientific name for vitamin B6
pyridoxine
138
what is the key function of vitamin B6 (pyridoxine)
transamination: synthesis of nonessential amino acids
139
what is the active form of vitamin B6 (pyridoxine)
PLP
140
what are secondary functions of vitamin B6 (pyridoxine)
- synthesis of glucose and some types of lipids - breakdown of glycogen for use in body - production of serotonin - hemoglobin synthesis
141
what are deficiency symptoms of vitamin B6 (pyridoxine)
- anemia - depression - dermatitis - convulsions - weakened immune response
142
what are toxicity symptoms of vitamin B6 (pyridoxine)
- nerve damage: numb feet or hands - ataxia: inability to walk
143
are toxicity symptoms of vitamin B6 (pyridoxine) reversible
many symptoms are NOT reversible
144
what is the scientific name for vitamin B9
folate
145
what are the two forms of vitamin B9 (folate)
- folate - folic acid
146
define folate
naturally occurring form of vitamin B6 (folate)
147
define folic acid
synthetic form of vitamin B6 (folate)
148
which form of vitamin B6 (folate) is easier to absorb
folic acid
149
what are the important functions of vitamin B6 (folate)
- needed for DNA replication during cell division - red blood cell synthesis - central nervous system formation during fetal development
150
what does DFE stand for
dietary folate equivalent
151
who has increased requirements for vitamin B9 (folate)
- women planning on becoming pregnant - pregnant and lactating women
152
what conditions occurs with vitamin B9 (folate) deficiency
macrocytic anemia
153
define macrocytic anemia
- large and immature red blood cells fewer in number than should be - causes red blood cells to have difficulty moving through capillaries
154
what is the umbrella term for conditions of newborns associated with vitamin B9 (folate) deficiency during pregnancyy
neural tube defects
155
what are the two types of neural tube defects
- spina bifida - anencephaly
156
define spina bifida
failure of spinal cord to close completely
157
define anencephaly
lack of or incomplete development of brain and skull
158
has the prevalence of neural tube defects increased or decreased over time and why
- decreased - due to folate fortification in foods
159
what is the scientific name for vitamin B12
cobalamin
160
what element is in vitamin B12 (cobalamin)
cobalt
161
where is vitamin B12 (cobalamin) often synthesized
bacteria in the large intestine
162
where is vitamin B12 (cobalamin) found naturally
foods of animal origin (proteins)
163
what is needed for vitamin B12 (cobalamin) to be absorbed
intrinsic factor
164
what is the antidote for cyanide poisoning
vitamin B12 (cobalamin)
165
what are the functions of vitamin B12 (cobalamin)
- converts folate to active form - maintains myelin sheath which insulates nerve fibers
166
what does the myelin sheath do
- insulates nerve fibers - increases speed of nerve impulses
167
describe how vitamin B12 (cobalamin) is digested and absorbed
- released from dietary protein in the stomach by pepsin and HCl - vitamin bound to intrinsic factor which protects it from degradation until absorption - absorbed in lower ileum
168
what happens to vitamin B12 (cobalamin) absorption as we age and why
- absorption decreases - lower intrinsic factor production and HCl secretion
169
what are conditions associated with vitamin B12 (cobalamin) deficiency
- macrocytic anemia - pernicious anemia
170
define pernicious anemia
anemia due to lack of intrinsic factor
171
what conditions can reduce intrinsic factor
- genetic defect - aging - bariatric surgeries

NUTR 202 (14 decks)

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