Monoclonal Antibodies Flashcards
(4 cards)
1
Q
4 pros of monoclonal antibodies
A
High Specificity
Can act on not druggable targets
Very efficacious
Long lasting treatment
2
Q
5 cons of mAbs
A
Expensive
Hard to deliver + store
Immunogenic
cancers can develop resistance
Cannot enter cells
3
Q
Example of mAb cardiotoxicity
A
Herceptin- elevates ROS in cardiomyocytes
4
Q
Example of mAb immune issues
A
Adalimumab downregulates immune system leading to more infections
