Monoclonal Antibodies (-mab) Flashcards
1
Q
Origin…
- o
- u
- xi
- zu
- xizu
A
O = mouse U = human Xi = chimeric Zu = humanized Xizu = chimeric/humanized hybrid
2
Q
Target…
- b(a)
- c(i)
- f(u)
- k(i)
- l(i)
- n(e)
- s(o)
- tox(a)
- t(u)
- v(i)
A
b = bacteria c = cardiovascular f = fungal k = interleukin i = immunomodulatory n = neural s = bone tox = toxin t = tumor v = viral
3
Q
Define…
- Mouse
- Human
- Chimeric
- Humanized
- Chimeric/humanized hybrid
A
Mouse = all mouse antibody Human = all human antibody Chimeric = mouse variable and complementarity regions Humanized = mouse complementarity regions only Hybrid = mouse complementarity, 1/2 mouse variable
4
Q
Alemtuzumab
A
Humanized anti-tumor
CD52
5
Q
Bevacizumab
A
Humanized anti-cardiovascular
VEGF
6
Q
Cetuximab
A
Chimeric anti-tumor
EGFR
7
Q
Rituximab
A
Chimeric anti-tumor
CD20
8
Q
Trastuzumab
A
Humanized anti-tumor
HER2
9
Q
Adalimumab
A
Human immunomodulatory
TNF-alpha
10
Q
Certolizumab
A
Humanized immunomodulatory
TNF-alpha
11
Q
Infliximab
A
Chimeric immunomodulatory
TNF-alpha
12
Q
Eculizumab
Treats?
A
Humanized immunomodulatory
C5 (complement)
PNH
13
Q
Natalizumab
Risk?
A
Humanized immunomodulatory
Alpha-4 integrin
PML risk
14
Q
Abciximab
A
Chimeric anti-cardiovascular
2b/3a
15
Q
Denosumab
A
RANKL
