Monosaccharide Metabolism Flashcards

1
Q

Glycolysis yields

A

2 pyruvate and a net gain of 2 ATP and 2 NADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

control points of glycolysis

A

phosphofructokinase 1 (PFK-1)

pyruvate kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ANAEROBIC GLYCOLYSIS

A

G6P to Lactate

key enzyme LDH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

FATES OF LACTATE

A

pyruvate to lactate = muscle
lactate transport = blood
lactate to pyruvate = heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

PFK 1

A

allosteric activator

ACTIVATORS

  • AMP
  • ADP

INHIBITORS

  • ATP
  • Citrate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Pyruvate kinase

A

ACTIVATOR
- Fructose 1,6 bisphosphate

INHIBITORS

  • ATP
  • Acetyl-CoA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ENERGETIC BALANCE OF ANAEROBIC GLYCOLYSIS

A

2 ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ENERGETIC BALANCE OF AEROBIC GLYCOLYSIS

A

5-7 ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ENERGETIC BALANCE OF ANAEROBIC GLYCOLYSIS IN RED BLOOD CELL

A

1 ATP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

METABOLISM OF FRUCTOSE

A

cant be controlled because the control point, PFK-1, is skipped

ex. high fructose corn syrup

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

GLUCONEOGENESIS

A

synthesis of glucose from non carbohydrates sources (Lactate, Glycerol, Amino acids)

takes place in the liver and kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

GLUCONEOGENETIC ENZYMES

A

Phosphoenolpyruvate Carboxykinase

Phosphofructophosphatase 1

Glucose-6-Phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Phosphoenolpyruvate Carboxykinase

A

induced by glucocorticosteroid hormones and glucagon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

PHOSPHOFRUCTOPHOSPHATASE 1

A

KEY ENZYME OF GLUCONEOGENESIS

competitive inhibitor

ACTIVATOR
- Citrate

INHIBITORS

  • AMP
  • Fructose 2,6 bisphosphate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Glucose-6-Phosphatase

A

Only present in liver, kidney and intestine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

METABOLISM OF FRUCTOSE 2,6-BISPHOSPHATE

A

Bifunctional enzyme

Regulated by covalent modification

allows liver to continue gluconeogenesis while other tissues are doing glycolysis

17
Q

PFK2

A

activated by epinephrine & glucagon

active when nonphosphorylated

18
Q

PFPase 2

A

activated by insulin

active when phosphorylated

19
Q

INSULIN

A

Activates glycolysis and inhibits gluconeogenesis

Decrease glycemia

20
Q

EPINEPHRINE AND GLUCAGON

A

Activate gluconeogenesis and inhibit glycolysis

Increase glycemia