More random BB SBAs Flashcards by Emer Mulholland

which receptor is associated with the paroxysmal depolarising shift in epilepsy?

NMDA

How well did you know this?

Not at all

Perfectly

Which deep brain structure is stimulated DBS in Parkinson’s?

Subthalamic nucleus

How well did you know this?

Not at all

Perfectly

Which of the following nucleus in the basal ganglia is input to the thalamus?

Glob pallidus internal

How well did you know this?

Not at all

Perfectly

Where are the Purkinje cells found?

Molecular layer of the cerebral cortex

How well did you know this?

Not at all

Perfectly

What is the term used to describe when a non-noxious stimulus elicits a pain response?

Allodynia

How well did you know this?

Not at all

Perfectly

Which type of receptor is the 5-HT3 receptor?

Ligand-gated ion

How well did you know this?

Not at all

Perfectly

45 y/o man collapses in a shopping centre while convulsing. The paramedics arrive 12 minutes later to find him still have a seizure. What is the acute treatment they administer?

Most likely IV diazepam

How well did you know this?

Not at all

Perfectly

What is naloxone?

Opioid antagonist
Used to block/reverse the effects of opioid drugs (good to use in opioid overdose)
Has high affinity for mu opioid receptors

How well did you know this?

Not at all

Perfectly

Which NTs promote sleep?

GABA
Melatonin
Adenosine

How well did you know this?

Not at all

Perfectly

Where does the superior peduncles of the cerebellum project to?

Thalamus

How well did you know this?

Not at all

Perfectly

What is long-term potentiation and depression?

To do with memory and learning see flashcard on memory and amnesia

How well did you know this?

Not at all

Perfectly

What receptor does memantine act on?

NMDA

How well did you know this?

Not at all

Perfectly

What increase the incidence of subdural haemorrhages, other than age?

Anticoagulants
Long-term alcohol abuse
Dementia
CSF leak

How well did you know this?

Not at all

Perfectly

What area is overactive in OCD?

*Amygdala (according to notes)

Answers on google drive:
Orbital gyrus 
Head of caudate nucleus
Insula 
ACC

NOT:
Medial PFC
Posterior caudate

How well did you know this?

Not at all

Perfectly

What other area/s of the brain is a target for DBS in Parkinson’s?

Zona incerta

Globus pallidus internal

How well did you know this?

Not at all

Perfectly

What is tardive dyskinesia?

involuntary, repetitive body movements - may include grimacing, sticking out the tongue, or smacking the lips.

Which drug has zero order?

Phenytoin

What is the general mode of action of benzodiazepines?

Positive allosteric modulators of GABAa

What receptor does sumatriptan bind to?

5HT1D/B

What is methadone?

Opioid substitute

What is the primary nucleus involved with cholinergic innervation of the cerebral cortex?

Nucleus Basalis of Meynert

Waves of 13-20 Hz (high frequency) but with low amplitude are indicative of what state in a person?

Normal waking

What is the most common causes of ischaemic stroke?

Thrombosis
Embolism
Systemic hypo perfusion (shock)
Cerebral venous sinus thrombosis

What is the mechanism of action of ecstasy?

Presynaptic releasing agent of 5-HT, NA, DA

Acts on the trace-amine associated receptor 1 and vesicular monoamine transporter 2

Give examples of SSRIs

Citalopram Fluoxetine Paroxetine Sertraline

Give examples of selective MAOb inhibitors

Rasagiline Selegiline Non-selective: Phenelzine Tranylcypromine Iproniazid

Which of the following drugs for schizophrenia is associated with agranulocytosis?

Clozapine

In an outpatient department, testing of which cranial nerve reflex would be most appropriate? (idk if there wad a scenario for this, it doesn't make much sense to me...)

Corneal Cough Gag Pupillary light reflex

following a major car accident, a man sustained multiple injuries...Upon arrival to the hospital, what is the first action taken in terms of management?

CT head Resuscitation Measure and management of ICP?

Which of the following drugs is a DOPA decarboxylase inhibitor and CANNOT cross the BBB?

Carbidopa

What brain structure comes after the hippocampus in the Paper memory circuit?

Mamillary body

What do the plaques in AD contained?

Beta amyloid

What receptor does marijuana bind to in the brain?

CB1

Which enzyme is at the site of inflammation and makes compounds that sensitise nociceptors?

COX-2 at inflammatory tissues

What fibres are involved in acupuncture?

A-delta