morph Flashcards
(82 cards)
1
Q
Edematous mucosa with loose stroma, hyperplastic mucus glands and infiltrated by neutrophils, eosinophils and plasma cells
A
nasal polyps
2
Q
tumor of posterolateral wall of the roof of the nasal cavity
A
Nasopharyngeal Angiofibroma
3
Q
tumor of lateral nose
A
Sinonasal (Schneiderian) Papilloma
4
Q
Fibrovascular stromal cores
A
Sinonasal (Schneiderian) Papilloma
5
Q
tumor of superior nose
A
Olfactory Neuroblastoma (Esthesioneuroblastoma)
6
Q
Small, blue, round cell neoplasm
A
Olfactory Neuroblastoma (Esthesioneuroblastoma)
7
Q
Large epithelial cells with oval or round vesicular nuclei, prominent nucleoli, and indistinct cell borders disposed in a syncytium-like array
A
Undifferentiated/basaloid nasopharyngeal carcinomas
8
Q
- Small, smooth, round bumps on the true vocal cords.
- Loose myxoid core, covered with squamous epithelium.
- May become keratotic, hyperplastic, or even slightly dysplastic.
- May ulcerate if the nodules impinge on each other.
A
Reactive Nodules (polyps) of the Vocal Cords
9
Q
raspberry like prolifs on true vocal cords
A
Squamous Papilloma of the Larynx
10
Q
keratin pearls and intercellular bridges
A
squamous cell carcinoma of larynx
11
Q
diminished wt, vol, acinar #
A
pulm hypoplasia
12
Q
wet, heavy lungs
A
pulm edema
13
Q
hyaline mem around alv (composed of necrotic epi debris and exuded proteins).
A
ARDS
14
Q
T2 pneumocyte hyperplasia
A
ARDS
15
Q
stiff lungs
A
ARDS
16
Q
resp bronchiole enlaregemtn in upper lobes
A
centriacinar emphysema
17
Q
uniform enlargement of entier acini in lower lobes
A
panacinar emphysema
18
Q
Cystic (air filled w thin walls) lesions (CT)
A
emphysema
19
Q
Mucus gland hypertrophy in trachea and bronchi + mucus hypersecretion (neutrophil proteases) in the lg airways.
A
chronic bronchitis
20
Q
Chronic inflammation=>leads to fibrosis and obstr of the small airways.
A
chronic bronchitis
21
Q
hyperemia
A
chronic bronchitis
22
Q
edema of lung mucus mems
A
chronic bronchitis
23
Q
bronchiolitis obliterans
A
chronic bronchitis (fibrosis causes obliteration of the lumen in severe cases)
24
Q
Overinflated lungs with patchy atelectasis.
A
asthma, esp status asthmaticus
25
Whorled mucus plugs (Curschmann spirals).
asthma, esp status asthmaticus
26
Microscopic lung edema, with eosinophils and charcot-leyden crystals (eosinophilic protein galectin-10).
asthma, esp status asthmaticus
27
bronchioles are distended with thick mucus associated with marked hyperplasia and hypertrophy of the mucus‐secreting cells
cf induced bronchiectasis
28
formation of mucous plugs and intense airway inflammation with eos.
Allergic Bronchopulmonary Aspergillois
29
dilated airways mostly in distal bronchioles in lower lobes
bronchiectasis
30
cystic and filled with mucopurulent secretions
bronchiectasis
31
Patchy interstitial fibrosis (frim rubbery white areas) in subpleural and interlobular septal distrib
idiopathic pulm fibrosis
32
Masson Bodies
• Cryptogenic Organizing Pneumonia (COP)
o AKA: (bronchiolitis obliterans organizing pneumonia (BOOP
-polypoid plugs of loose organizing CT in alveolar ducts, alveoli and bronchioles.
33
Intrapulmonary rheumatoid nodules
Rheumatoid Arthritis on the lung --> pulm fibrosis
34
Diffuse interstitial fibrosis (nonspecific > UIP)
systemic sclerosis on the lung --> pulm fibrosis
35
Patchy, transient parenchymal infiltrates
SLE on the lung --> pulm fibrosis
36
Mild/moderate chronic interstitial inflammation with lymphocytes + plasma cells.
Nonspecific Interstitial Pneumonia (NSIP): cellular pattern
37
Black pigmented lesions formed by coal laden Mf
anthracosis: Coal Workers Pneumoconiosis
38
1-2mm coal macules with dust filled Mf or slightly larger coal nodules with collagen adjacent to respiratory bronchioles.
Simple Coal Workers Pneumoconiosis
39
Large, blackened collagenous scars with central ischemic necrosis replace portions of the lung --> massive fibrosis
Complicated Coal Workers Pneumoconiosis (CCWP)
40
initially Nodules are pale or black
- -> Become larger, more diffuse with progression forming large areas of massive fibrosis (scars) that contains a central area of whorled collagen surrounded by dust laden Mfs
- in upper lung or hilar LNs.
silicosis: Pneumoconiosis
41
startl in low lung and works its way up
asbestos: Pneumoconiosis
42
Golden brown, fusiform or beaded rods 'dumbbell shaped' with translucent center and consist of asbestos fibers coated with iron-containing proteinaceous material.
asbestos: Pneumoconiosis
| - Asbestos Bodies:
43
Pleural plaques: well circumscribed plaques of dense collagen; anterior and posterolateral aspects of the parietal pleura and over the domes of the diaphragm
asbestos: Pneumoconiosis
| * no asbestos bodies
44
Non-necrotizing granulomas with tightly clustered epithelioid Mfs and giant cells.
--> may become enclosed within fibrous rims or replaced by hyaline fibrous scars
sarcoidosis
45
Schaumann bodies
sarcoidosis
Laminated, calcified proteinaceous concretions.
*not dx
46
Asteroid bodies
sarcoidosis
Stellate inclusions within giant cells.
*not dx
47
Interstitial pneumonitis and interstitial fibrosis of the bronchioles w Noncaseating granulomas
Hypersensitivity Pneumononitis (extrinsic alveolar alveolitis)
48
Focal lung consolidation w extensive lymphocyte and eos infiltration into the walls and alveolar spaces
Idiopathic Chronic Eosinophilic Pneumonia
49
Focal collections of Langerhans cells (+ eos).
Pulmonary Langerhans Cell Histiocytosis
50
Small lamellar bodies with electron dense cores
ATP- binding cassette protein member 3 (ABCA3) - surfactant protein issue
51
abn lamellar bodies in t2 pneumocytes (hyperplasia), interstitial fibrosis, and alveolar simplification.
Surfactant Dysfunction Disorder
52
Heavy lungs with areas of red-brown consolidation.
| Intraalveolar hemorrhage + hemosiderin laden Mf
goodpastures synd
53
URI with mucosal hyperemia + swelling + lymphomonocytic and plasmacytic infiltration of submucosa + mucus overproduction => plug sinuses or Eustachian tubes
viral pneumonia
54
infalmm of alv wall => wide alv septa
viral pneumonia
55
Vocal cord swelling + abundant mucus production.
Viral Laryngotracheobronchitis and Bronchiolitis
56
Supprative destruction of the lung parenchyma within the central area of cavitation.
pulm abcess
57
granulomas with caseating, coagulative necrosis which undergo fibrosis and concentric calcification (tree-bark appearance).
Histoplasma capsulatum
58
Focal accumulations of mononuclear phagocytes filled with fungal yeasts throughout the body, NO granulomas
Histoplasma capsulatum
59
miliary pattern
Histoplasma capsulatum, Blastomyces dermatiditis
60
suppurative granulomas with persistence of yeast cells d/t limited Mf capabilities to kill this fungus
Blastomyces dermatiditis
61
Involvement of the skin and larynx is assoc with marked epithelial hyperplasia
Blastomyces dermatiditis
62
Within Mf the fungus is seen as thick-walled, nonbudding spherules 20-60 microns and filled with endospores
Coccioides immitis
63
Lesions can be granulomatous or pyogenic or mixed
Coccioides immitis
64
dysplastic, mildly fibrotic pneumocytes, under 5 mm
Atypical Adenomatous Hyperplasia
65
Malignant epithelial tumor with glandular differentiation or mucin production.
Adenoma
66
cauliflower mass
scc
67
keratinization (squamous pearls) and intercellular bridges
scc
68
Small cells with scant cytoplasm, illdefined borders, finely granular nuclear chromatin (salt & pepper) + lack of nucleoli.
sclc
69
Azzopardi effect:
sclc
| -Basofilic staining of vascular walls dt encrustation by DNA from necrotic tumor cells
70
Expression of chromogranin, synaptophysin, CD57(6?
sclc
71
Organoid, trabecular, palisading, ribbon, or rosette-like arrangements of cells separated by a delicate fibrovascular stroma.
carcinoid tumors
72
penetrate bronchial wall, fanning out 'collarbutton lesion'
carcinoid tumors
73
dense-core granules chara of other NE tumor
atypical carcinoid tumors
74
IM: contains serotonin, neuron-specific enolase, bombesin, calcitonin, other peptides
atypical carcinoid tumors
75
Nodules of connective tissue (cartilage, fibrous, fat) intersected by epithelial clefts.
lung hamartoma
76
Proliferation of perivascular epithelioid cells with markers of melanocytes + SMC's
Lymphangioleiomyomatosis
77
Cystic, emphysema like expansion of terminal airspaces, thickening interstitium and obstruction of lymphatic vessels
Lymphangioleiomyomatosis
78
Grey/white, round, well defined single peripheral mass, with calcium deposits.
Inflammatory Myofibroblastic Tumor
79
dense fibrous tissue with occasional cysts filled with viscous fluid.
-Whorls of reticulin and collagen fibers with interspersed spindle cells resembling fibroblasts.
Solitary fibrous tumor
80
Tumor is spread diffusely over the lung surface and fissures to form an encasing soft, gelatinous, graypink tumor sheathe
malig mesothelioma
81
Malignant, spindle-shaped cells resembling a fibrosarcoma.
Sarcomatoid Pattern :malig mesothelioma
82
Epithelium like cells form tubules and papillary projections resembling adenocarcinomas with cuboidal, columnar, or flattened cells.
Epithelioid Pattern : malig mesothelioma
