prognosis

Question 1

SCLC

Answer 1

sensative to radiation/chemo if localized, but most pts prsent w mets

Question 2

ALI-DAD

Answer 2

Progresses rapidly with most deaths occurring in 12 mos

Question 3

malig mesotheiolma

Answer 3

50% 1 yr mortality, few survive > 2 yrs.

Question 4

Nonspecific Interstitial Pneumonia (NSIP)

Answer 4

good

Question 5

bronchiectasis

Answer 5

good d/t antbs and PT

Question 6

Lymphangioleiomyomatosis

Answer 6

slow progression over decades

Question 7

emphysema

Answer 7

Development of cor pulmonale is a poor prognostic factor

Question 8

silicosis: pneumocosis

Answer 8

continues to worsen even if remove exposure, increased TB, lung CA

Question 9

Extranodal NK/T cell lymphoma

Answer 9

o Fatal if spread to cranial vault or necrosis with infection and sepsis.
o Relapse and recurrences remain common and is assoc with a poor outcome.

Question 10

sarcoidosis

Answer 10

 Most recover with minimal residual s/s +/- steroids.
 20% with permanent lung or ocular dysfunction.
 15% succumb to pulmonary fibrosis and cor pulmonale

Question 11

adenocarcinoma

Answer 11

prolonged if EGFR; bad if KRAS

Question 12

ATP- binding cassette protein member 3 (ABCA3) - surfactant protein issue

Answer 12

death in 1st few mos

Question 13

idiopathic pulm fibrosis

Answer 13

die 3 yrs after dx

Question 14

Nasopharyngeal Angiofibroma

Answer 14

o Locally aggressive + intracranial extension = 20% recurrence.
o 9% of cases are fatal d/t hemorrhage or intracranial extension

Question 15

ARDS

Answer 15

o Most pts will recover, but many of them can still have physical and cognitive impairment.
o In severe cases, there can be scarring from the interstitial fibrosis that results in chronic pul dz

Question 16

squamous cell carcinoma of larynx

Answer 16

depends on level atypia at first dx

Question 17

Pulmonary Langerhans Cell Histiocytosis

Answer 17

resolve w smoking cessation or aquire BRAF –> need transplant

Question 18

nasopharyngeal carcinoma

Answer 18

 Non-keratinizing: 70-90%.

 Keratinizing: 20%.

Question 19

viral pneumonia

Answer 19

mild and resolve spontaneously.

Question 20

asbestosis: pneumocosis

Answer 20

increased risk lung CA –> then worse prognosis

Question 21

infectious rhinitis

Answer 21

clears 1 w

Question 22

• Cryptogenic Organizing Pneumonia (COP)

o AKA: (bronchiolitis obliterans organizing pneumonia (BOOP)

Answer 22

o Pts may recover spontaneously, most require 6 months of steroids.

Question 23

Surfactant protein B mutation

Answer 23

death in 1st 3-6 mos

Question 24

NUT Midline Carcinoma

Answer 24

resistant to therapy: under 1 y

Question 25

Hereditary Pulmonary Alveolar Proteinosis

Answer 25

rapidly fatal

Question 26

atelectasis

Answer 26

Reversible (except in contraction).