Flashcards in Motor Unit Disorders Deck (20):
Motor Unit Disorders
Disorders of the motor unit generally cause muscle weakness and atrophy of skeletal muscle that may of neurogenic, neuromuscular, or myopathic origin
Guillain Barre Syndrome
An acute inflammatory condition involving the spinal nerve roots, peripheral nerves and in some cases selected cranial roots, (neurogenic).
Autoimmune disease with no know cause or cure.
Guillain Barre Syndrome what does theImmune system destroy
the myelin sheath that surrounds the axons of peripheral nerves or the axons.
When does Guillain Barre Syndrome typically appear
Often follows a viral illness, immunizations, or surgery.
Guillain Barre Syndrome Symptoms
Initial symptoms weakness and sensory changes in LE’s.
Rapid progressive weakness from distal to proximal
Inability to feel textures, heat, pain.
Complaints of tingling, crawling skin, or painful sensations
May progress to problems with breathing, speaking, swallowing, BP, heart rate, or total paralysis.
Guillain Barre Syndrome Treatment
Energy Conservation/Work simplification/AE
Avoid over fatigue
Mobile arm supports
A highly contagious viral disease that is transmitted via fecal-oral (primarily spread through unsanitary conditions and or through poor handwashing).
Why don't all people know they have polio
People acquiring the disease can be asymptomatic but still spread the disease.
Is flaccid paralysis typical?
no results in less than 1% of all polio infections, usually followed by a full recovery. (if paralysis lasts longer than 12 months usually permanent).
3 Types polio
Spinal polio: .
Six criteria for Postpolio syndrome:
1. Prior paralytic poliomyelitis
2. Period of complete or partial recovery
3. Gradual or sudden onset of progressive and persistent; muscle weakness, abnormal muscle fatigue.
4. New difficulties with breathing/swallowing.
5. Symptoms last for at least a year
6. Other cause of symptoms ruled out
Postpolio syndrome (PPS).
25 -40%These adults are currently dealing with new muscle pain and increasing weakness or developing new weakness /paralysis that is diagnosed as Postpolio syndrome (PPS).
Postpolio syndrome (PPS) Pathogenesis
Failure of oversized motor units created during the recovery process of paralytic poliomyelitis (not contagious).
Additional PPS disabling problems:
Contractures (prolonged shortening of muscle joint)
Increased difficulty with ADLs/IADLs, ambulation, transfers, stairs, home management, driving, eating/swallowing and bowel/bladder control
Energy conservation/Work Simplification/Pacing
Purse lip breathing
Address psychosocial and emotional aspects
ADLs, IADLs, transfers, home management, driving, bowel & bladder
ROM exercises (conservative)
Family training, AE
The most common chronic disease involving a disorder of chemical transmission at the nerve-muscle synapse, or neuromuscular junction (neuromuscular disorder)
Myastensis Gravis Caused by
an autoimmune response in which antibodies are produced that block, alter, or destroy the nicotinic acetylcholine receptors on the post synaptic membrane and interfere with synaptic transmission at the nerve muscle junction.
Myastensis Gravis defective neurotransmissions causes
skeletal (voluntary) muscles typically cranial muscles become weak (eye, eyelids, chewing, swallowing, coughing and facial expression).
Eyelid drooping(pytosis), double vision (diplopia),
oropharyngeal muscle weakness causing difficulty with chewing, swallowing, and speaking
Myastensis Gravis Medical Management
Thymectomy (secondary to abnormalities of the thymus)
High dose immune globulin