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Flashcards in MRCP 2 Deck (167)
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1

Which DMARD is most likely to cause mouth ulcers

Methotrexate

2

Which steroid sparing agent can be used in GCA

Methotrexate

3

Which porphyria syndromes present with skin sx

PCT
Congenital erythropoietic porphyria
Eryrthropoietic protoporphyria

4

What are two contraindications for sildenafil use in ED?

Unstable angina
Recent MI or stroke (prev 6mths)
Use of Nicorandil or other nitrates
Hypotension

5

What is the name of the syndrome where a close person has been replaced as an imposter

Capgras syndrome

6

What is the treatment for methotrexate toxicity

Folinic acid - bypasses DHFR step, needed to activate folic acid

7

Which drug should be given in thyroid storm

PTU - acts quicker than carbimazole

8

What is the first line investigation for stable angina

CT coronary angiography
If equivocal -> MRI perfusion study
If positive and intervention warranted -> angiography

9

Pompe disease
What is it
What are the features
What is the treatment

Deficiency of a-galactosidase causing glycogen deposition in organs
Risks cardiomyopathy and cardiomegaly
Treated with glucosidase

10

Drugs that are CI in idiopathic intracranial htn (7)

Tetracyclines
Lithium
Contraceptives
Cimetidine
Isotretinoin
Steroids
Thyroxine

11

Sjogrens classically causes which type of renal tubular acidosis

Type 1

12

What is the first line treatment for restless legs syndrome

DA agonists - ropinerole

13

When should FFP be given in a variceal bleed

Fibrinogen <1
INR >1.5

14

What is the mode of action of febuxostat

Xanthine oxidase inhibitor, like allopurinol

15

Bilateral loin pain - what diagnosis must be considered

Retroperitoneal fibrosis

16

When is it safe to fly post pneumothorax

One week pos resolution on XR

17

Retinitis pigmentosa, chronic progressive external ophthalmoplegia, bilateral ptosis, mild cerebellar signs and a cardiac conductive defect (first degree heart block).

What is the diagnosis

Kearns Sayre - mitochondrial disorder

18

How are palpitations in cocaine toxicity treated

Verapamil

19

What is the treatment for Norwegian scabes

Ivermectin orally

20

haemangioblastomas can secrete what

Epo

21

Does acute interstitial nephritis cause proteinuria

Yes
Also haematuria, eosinophilia & rash

22

Which antibiotic should be avoided with aminophylline

Ciprofloxacin, due to inhibition of CYP 1A2 causing accumulation of aminophylline and toxicity

23

Kearns Sayre - what are the features

Three in the eyes
Retinitis pigmentosa
Chronic ophthalmoplegia
Bilateral ptosis

Two elsewhere
Cardiac conduction defects
Mild cerebellar signs

24

What are the two types of amyloidosis and what are the underlying causes

AL - driven by light chain dyscrasia / myeloma
AA - driven by inflammation - RA, and spond

25

Purkinje cell antibody
CF
Associated with

Peripheral neuropathy
Breast cancer

26

ASDs usually cause what on ECG
How does the axis help to distinguish

RBBB
LAD - more likely ostium primum (PL)
RAD - more likely ostium secondum (RS)

27

What two drugs have evidence for improvement of fibromyalgia

Duloxetine and pregabalin

28

What is the treatment for GI bleeding on apixaban

Tranexamic acid +/- prothrombin complex

29

Canakinumab
MOA
Indication

interleukin-1 beta receptor antagonist
Tx for acute gout in those not tolerant of NSAIDs & colchicine

30

What is the treatment for lymphatic filariasis

Diethylcarbamazine