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Flashcards in MRCP Deck (569)
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1

Wilcoxon signed-rank test
Parametric or non-parametric data

Non-parametric
compares two sets of observations on a single sample

2

Which drugs can cause cirrhosis (3)

methotrexate
methyldopa
amiodarone

3

Inheritance of Ocular albinism

X-linked recessive

4

What is the antibiotic regime of choice for pseudomonas in CF

Ceftazidime and tobramycin

5

What drug decreases concentration of Li

Acetazolamide & osmotic diuretics

6

Which GN typically present with nephritic syndrome (2)

Typically presents with nephritic syndrome (haematuria, hypertension)

Rapidly progressive glomerulonephritis - aka crescentic glomerulonephritis
Rapid onset, often presenting as acute kidney injury
causes include Goodpasture's, ANCA positive vasculitis and SLE

IgA nephropathy - aka Berger's disease, mesangioproliferative GN
typically young adult with haematuria following an URTI

7

When are steroids not indicated first line, for GN?

Membranous - tx with BP control and ACEi
Membranoproliferative - steroids are ineffective; can use eculizumab
Diffuse proliferative (post-strep) - self limiting

8

What are the driving restrictions for syncope (4)

Simple faint: no restriction
single episode, explained and treated: 4 weeks off
single episode, unexplained: 6 months off
two or more episodes: 12 months off

9

ANP is mainly secreted by the L or R atrium

Right atrium

10

Docetaxel
MOA
SE

MOA: antimicrotubule agent; Prevents microtubule depolymerisation and disassembly, decreasing free tubulin
SE: Neutropaenia

11

Glossopharyngeal nerve (IX)
Vagus nerve (X)
Accessory nerve (XI)

Posterior meningeal artery
Ascending pharyngeal artery
Inferior petrosal sinus
Sigmoid sinus
Internal jugular vein

Which skull foramen

Jugular foramen

12

Bronchial malignancy is associated with which skin disorder

Erythema gyratum repens
Erythematous scaling rash over the abdomen
Wood grain appearance

13

Iron-deficiency anaemia - cells seen on microscopy (2)

target cells
'pencil' poikilocytes

14

Which anti TB drug is most likely to cause drug-induced lupus

procainamide
hydralazine
Isoniazid

15

Vincristine, vinblastine
MOA
SE

MOA: antimicrotubule agents; Inhibits formation of microtubules - act in mitosis phase of cell cycle
SE: Vincristine: Peripheral neuropathy (reversible) , paralytic ileus
Vinblastine: myelosuppression

16

Paraneoplastic syndromes - Anti-Hu
Associated with (2)
CF (3)

Associations: small cell lung carcinoma and neuroblastomas

CF
sensory neuropathy - may be painful
cerebellar syndrome
encephalomyelitis

17

Histiocytosis X is a cause of cranial or nephrogenic DI

Cranial

18

6-mercaptopurine
MOA
SE

MOA: antimetabolite; Purine analogue that is activated by HGPRTase, decreasing purine synthesis
SE: Myelosuppression

19

IFN-gamma
Function
Indications (2)

Produced by T lymphocytes and NK cells
Weaker antiviral action, more of a role in immunomodulation particularly macrophage activation
Chronic granulomatous disease and osteopetrosis

20

Secretin
Released by which cells
Stimulus
Effect

S cells

Acidic chyme and fatty acids

Increases pancreatic secretions and hepatic duct cells.
Decreases gastric acid secretion
Trophic effect on pancreatic acinar cells

21

Inheritance of Lesch-Nyhan syndrome

X-linked recessive

22

Mann-Whitney U test
What does it test
Parametric or non-parametric data

Non-parametric
Unpaired data

23

Inheritance of Von Willebrand's disease (types 1 and 2) type 3

1 and 2 -> AD; 3 -> AR

24

What is the bug in cat scratch fever
What is the tx

Bartonela hensalae
Immunocompetent - supportive tx
Systemic disease - cipro

25

What is increased in lead poisoning

Urinary coproporphyrin

26

What are the features of cubital tunnel syndrome
Which nerve is involved

Ulnar nerve
Tingling in ulnar nerve distribution; weakness is late
Worse when elbow is resting on a surface or the arm is flexed

27

When are steroids indicated first line, for GN?

Minimal change disease
FSGS
IgA / mesangioproliferative
Rapidly progressive

28

Causes of a false positive VDRL test (4)

'SomeTimes Mistakes Happen' (SLE, TB, malaria, HIV)

29

commonest SE of nicorandil

ulceration

30

complication of pcp

pneumothorax