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MSCT > MSCT Week 5: Papulosquamous Skin Eruptions > Flashcards

MSCT Week 5: Papulosquamous Skin Eruptions Flashcards

(73 cards)

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1
Q

Papulo means in papulosquamous eruptions

A

Plaque - raised skin lesion with epidermal component

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2
Q

Squamous in papulosquamous means

A

scale or excess shedding of keratinocytes

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3
Q

Pathology?

A
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4
Q

Pathology?

A
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5
Q

Hyperkeratosis is?

A

Thickened Stratum Corneum

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6
Q

Parakeratosis is?

A

Presence of keratinocytic nuclei in the stratum corneum

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7
Q

Acanthosis is?

A

Thickened spinous layer also known as epidermal hyperplasia

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8
Q

Acanthosis AKA?

A

Epidermal Hyperplasia

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9
Q

Pathology?

A
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10
Q

Descriptions

A
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11
Q

Pathology?

A
  • Acanthosis
  • Hyperkeratosis
  • Parakeratosis
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12
Q

Pathology?

A

Acanthosis

Hyperkeratosis

cant see Parakeratosis

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13
Q

Pathology?

A
  • Hyperkeratosis
  • Parakeratosis
  • Neutrophils in the stratum corneum
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14
Q

Pathology?

A

Hyperkeratosis

Parakeratosis

acanthosis might be hard to see from this magnification

neutrophils in the stratum corneum

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15
Q

What is Psoriasis?

A

A chronic, inflammatory skin condition

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16
Q

Psoriasis prevalence?

A
  • 2% of the US population
  • can be seen at any age, peaks in diagnosis in early 20s and middle age
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17
Q

Psoriasis Risk Factors

A

Strong genetic component (1/3 have affected 1st degree family)

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18
Q

Psoriasis Characteristics

2 listed

A
  • Waxes & Wanes but has a chronic tendency
  • May or may not be itchy
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19
Q

Psoriasis Characteristics Overview

A
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20
Q

Psoriasis Age of Onset

A

can be seen at any age, peaks in diagnosis in early 20s and middle age

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21
Q

Psoriasis Morphologies

8 listed

A

Plaque

Guttate

Inverse/Flexural

Generalized/Erythrodermic

Pustular

Acral/Palmoplantar

Auspitz Sign = pinpoint bleeding in dermis when scale removed

Clinical pearl: Nail Pitting

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22
Q

Guttate Psoriasis

A

Having drops or droplike markings

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23
Q

Inverse/Flexural Psoriasis appears where on the body?

A

in the skin folds like arm pits

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24
Q

Psoriasis type?

A

Plaque

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25
Psoriasis type?
Inverse/Flexural
26
Psoriasis type?
Generalized/Erythrodermic
27
Psoriasis type?
Guttate
28
Psoriasis type?
Pustular
29
Psoriasis type?
Acral/Palmoplantar
30
Common locations of psoriasis
31
32
Identify
33
Identify
34
Topical Treatments for Psoriasis 5 listed
35
Corticosteroids for types of Psoriasis
All types
36
Calcipotriene (Vitamin D Derivative) for types of Psoriasis
* In combination or rotation w/ topical steroids * facial or genital
37
Retinoids for types of Psoriasis
Thicker plaques, in combination w/ topical steroid
38
Coal Tar for types of Psoriasis
Plaque Psoriasis
39
Calcineurin Inhibitors for types of Psoriasis
Off-label for facial or flexural/genital
40
Corticosteroids Side Effects
Skin Atrophy Striae Hypertrichosis if used inappropriately (systemic absorption)
41
Calcipotriene Side Effects
* Skin irritation * Mild photosensitivity
42
Coal Tar Side Effects
Skin irritation Odor Staining of clothing
43
Calcineurin Inhibitors Side Effects
Skin irritation
44
Systemic Treatments for Psoriasis
45
Systemic Treatments for Psoriasis When should they be considered?
in widespread/debilitating disease
46
Systemic Treatments for Psoriasis and corticosteroids
Do not give systemic corticosteroids as this may severely flare disease on rebound after discontinuing
47
Psoriasis Histological characteristics
Acanthosois hyperkeratosis hyper-proliferative disease (14 days to rise from basal to corneum instead of 28 days)
48
Striae are?
Stretch marks
49
Psoriasis has been recently shown to have an increased risk or association with?
* Cardiovascular Disease * Obesity
50
Atopic Dermatitis is associated with?
Asthma
51
Asthma is associated with this skin condition?
Atopic Dermatitis (Eczema)
52
Psoriatic Arthritis and other comorbidities
53
Psoriasis is a __________ disease with __________ inflammation
systemic disease with systemic inflammation
54
Pathology?
Atopic Dermatitis * Spongiosis (desmosomal attachments visible between keratinocytes) * eosinophils in the bottom left * langerhans cells
55
Atopic Dermatitis AKA
Eczema
56
Atopic Dermatitis is usually diagnosed when?
In infancy or early childhood
57
Atopic Dermatitis Characteristics
* Almost always itchy (pruritus) * up to 25% of the pediatric population but can persist into adulthood * waxes & Wanes but a chronic condition
58
Atopic Dermatitis is most commonly found where on the body?
59
Identify
60
Histology for Atopic Dermatitis
61
Pathology?
* Atopic Dermatitis * spongiosis
62
What Percentage of children with atopic dermatitis will have or develop another atopic condition?
50-80%
63
Pillars of treatment: Atopic Dermatitis 4 listed
* issue with skin barrier so prevent infection or treat with antibiotics, irritants or allergens Topical antibiotics * addressing the itch-rash cycle (oral antihistamines) * Anti-inflammation (topical cortical steroids (rarely systemics)
64
Question 1
Allergic Contact Dermatitis
65
Contact Dermatitis is caused by?
Inflammatory Rxns caused by an externally applied substance * either allergic or irritant
66
Allergic Contact Dermatitis description
Contact w/ particular substance causes DELAYED hypersensitivity Reaction Previous exposure/sensitization required
67
Irritant Contact Dermatitis Description
* Contact with an irritating or toxic substance causes rxn (in most people who come in contact w/ it depends on the frequency * No previous exposure required * Ex. Harsh soap/detergent, alcohol gel, etc
68
Allergic Contact Dermatitis (ACD) clinical description
69
Question 2
reddish polygonal pruritic bumps on the wrist
70
Identify
71
Pathology
* hypergranulosis * band of lymphocytes at the dermal-epidermal junction (lykinoid infiltrate) * sawtooth of Rete Ridges * Lichen Planus
72
Virus shown to be associated with Lichen Planus?
Hepatitis C Virus
73
Clinical pearl of Psoriasis
Nail Pitting & Auspitz sign

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