MSK - Bilateral Knee Pain Flashcards

1
Q

What is Enthesitis?

A

Inflammation of the entheses i.e. the sites where tendons or ligaments insert into the bone

  • Associated with HLA B27 arthropathies particularly seronegative ones - remember via PAIR mneumonic:
    • Psoriasis / psoriatic arthritis
    • Ankylosing spondylitis
    • Inflammatory bowel disease
    • Reactive arthritis
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2
Q

How many joints are affected when the following terms are used?

  1. Monoarticular
  2. Oligoarticular
  3. Polyarticular
A
  1. One
  2. ≤ 4
  3. > 4
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3
Q

Which joints are often affected by Osteoarthritis?

A
  • Large-weight bearing joints (Hip, knee, ankle, lumbar spine, cervical spine)
  • Foot: MTP
  • Hands: CMC, PIP and DIP, 1st IP, 1st MCP
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4
Q

What is Diclofenac (Voltarol)?

A

It is a NSAID used for pain/inflammation relief in:

acute gout, rheumatic disease and postoperative pain

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5
Q

If a patient presents with a recent history of exacerbation of pain/stiffness at the knee joint with swelling, what conditions might you consider?

Of those conditions which is diuretics a risk factor for?

A
  1. Crystal - gout / pseudogout
  2. Septic arthritis
  3. Mechanical disruption (meniscal, ligaments, bursa)
  4. Rapidly progressive OA
  5. Osteonecrosis

Diuretics are a risk factor for Gout

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6
Q

What features of a joint examination might indicate an osteoarthritic joint?

A
  • Cool effusion (warm indicates inflammation/infection)
  • Pain on movement
  • Reduced ROM
  • Crepitus
  • Antalgic gait
  • Weakness +/- muscle wasting
  • Joint line tenderness
  • Deformity
  • Bony swellings (osteophytes)
  • Joint instability
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7
Q

What are the names given to bony swellings / nodal osteoarthritis at the:

  1. PIP joints
  2. DIP joints
A
  1. Bouchards nodes
  2. Heberdens nodes
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8
Q

What condition do these hands likely show?

A

Osteoarthritis

  • Bouchards nodes: left (2,4,5) right (4,5)
  • Heberdens nodes: left (2-5) right ( 2-5)
  • Z-thumb both hands
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9
Q

What investigations might you do in someone with suspected OA?

A

Investigations:

  1. Bloods:
    • Inflammatory markers - CRP/ESR (rule out inflammatory condition)
    • FBC + U+Es - assess baseline
    • If concerned about inflammatory overlap then Rf and anti-CCP
  2. X-ray of afflicted joints and common offenders i.e. hands, ankle etc.
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10
Q

What are the X-ray features of OA described by the LOSS mneumonic?

A
  • Loss of joint space
  • Osteophytes on the joint margins
  • Subchondral bone sclerosis
  • Subchondral cysts - small pseudocystic areas with sclerotic walls situated in the subchondral bone
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11
Q

What are the management options for OA using the CAN mneumonic (Conservative, pharmacological, surgical)?

A

Conservative:

  • Patient education
  • Weight loss
  • Exercise/physiotherapy
  • Appropriate footwear + walking aids

Pharmacological:

  • Analgesia
    • Topical NSAIDs / capaiscin cream
    • WHO Ladder – paracetamol, NSAIDs, opiods
    • If prescribing oral NSAIDs also consider PPI for gastroprotection
  • Intra-articular steroid injection for moderate to severe pain

Surgical:

  • Surgery is considered in pts with symptoms that have a substantial impact on quality of life and are refractory to non-surgical treatment
  • Many different options
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12
Q

NICE guidelines say we should diagnose OA in patients if they meet 3 conditions, what are they?

A
  1. Pt is 45 or over AND
  2. has activity-related joint pain AND
  3. has either 1) no morning joint-related stiffness or 2) morning stiffness that lasts no longer than 30 mins
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13
Q

What is the most common form of arthritis?

A

Osteoarthritis

  • 50-80% of the population will have radiographic evidence of OA >65 years
  • ~ 3% of the population have symptomatic OA
  • Often progresses gradually but can be rapidly progressive e.g. 1/3rd of knee OA
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14
Q

What are the risk factors for OA?

A
  • Age > 50
  • Gender F > M
  • BMI
  • Previous joint injury
  • Intense sport activities
  • Occupation (hand, hip)
  • Quadriceps strength (knee OA)
  • Alignment (knee OA) e.g. valgus (knocked knees) or varus (bow legs)
  • Genetic
  • Secondary OA
  • Pistol grip deformity (hip) - x-ray sign of CAM-type femoroacetabular impingement (proximal femur is shape of flintlock pistol)
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15
Q

What is ‘Pistol grip deformity’ of the hip?

A

It is a radiological sign of cam-type femoracetabular impingement - this is a syndrome of pain + limited hip motion

  • Caused by morphological abnormality of femur head / neck
  • Cam-type = aspherical shape of femoral head due to bony protrusion, commonly at the anteriosuperior aspect of femoral head-neck
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16
Q

What is the main modifiable risk factor for OA?

A

BMI

17
Q

What are some secondary causes of OA?

Here are some useful headings:

Metabolic, traumatic, anatomical, neuropathic, inflammatory

A

Metabolic:

  • Crystal-associated (gout, calcium pyrophosphate i.e. pseudogout)
  • Acromegaly
  • Haemachromatosis
  • Wilson’s disease
  • Haemoglobinoathies
  • Collagenopathies

Traumatic:

  • Joint injury
  • Surgery e.g. meniscectomy
  • Fracture through a joint or osteonecrosis

Anatomical:

  • Slipped femoral epiphysis
  • Epiphyseal dysplasia
  • Legg-Perthe’s disease, Blount’s disease
  • Congenital dislocation of the hip
  • Unequal leg lengths
  • Hypermobility syndromes

Neuropathic:

  • Diabetes
  • Syphilis

Inflammatory:

  • Any inflammatory arthropathy
  • Septic Arthritis
18
Q

What is the function of articular cartilage?

A

Shock absorbtion + gliding of bones

19
Q

What are the common presenting features of OA?

A
  • Joint pain - worse on movement / exercise, relieved by rest
  • Morning stiffness lasting < 30 mins
  • Night pain - can occur in severe OA
  • Knee malalignment - knee valgus (knocked) /varus (bow)
  • Muscle wasting
  • Palpable bony swellings (osteophytes)
  • Joint effusions (cool - not warm as in inflammation)
  • Crepitus on joint movement
20
Q

As OA progresses what pathophysiological joint changes occur?

A
  1. Joint tissue macrophage stimulation –> ↑ cytokines (TNF-alpha, IL-6, VEGF etc) –> immune cell joint infiltration + neovascular growth
  2. Immune cells –> ↑ proteases –> articular cartilage break down
    • Age also thins cartilage:
      • ↓ hydration of cartilage
      • ↑ brittle bones
  3. Cytokines stim osteocytes –> stim osteablasts –> bone deposition in the form of subchondral sclerosis + osteophytes
  4. Other cytokines in joint e.g. prostaglandins and bradykinin –> stim pain fibres
21
Q

What is a syndeosmophyte?

A

Is a bony growth inside a ligament (often spinal ligaments of the intervertebral joints - leading to fusion of vertebrae)

  • Similar to osteophytes
  • Ankylosing spondylitis patients = prone to syndesmophytes
22
Q

what is the stepwise management of analgesia in OA?

A
  1. Oral paracetamol + topical NSAID/capsaicin!
  2. Oral NSAIDs + PPI (not constantly)
  3. Opiates (not effective long-term → tolerance)
23
Q

What advice would you give post-hip replacement to minimise risk of disclocation?

A
  • avoid flexing the hip > 90 degrees
  • avoid low chairs
  • do not cross your legs
  • sleep on your back for the first 6 weeks
24
Q

What are 3 common complications for hip replacement?

A
  1. wound and joint infection
  2. thromboembolism (NICE recommend patients receive low-molecular weight heparin for 4 weeks following a hip replacement)
  3. dislocation (remember advice)
  • patients receive both physiotherapy and a course of home-exercises
  • walking sticks or crutches are usually used for up to 6 weeks after hip or knee replacement surgery