MSK/DERM

Question 1

NSAID that irreversibly inhibits cyclooxygenase (both COX-1 and COX-2)

Answer 1

Aspirin

Question 2

Low dose (< 300 mg/day): 􀁲 platelet aggregation. Intermediate dose (300–2400 mg/day): antipyretic
and analgesic. High dose (2400–4000 mg/day): anti-inflammatory.

Answer 2

Aspirin

Question 3

Gastric ulceration, tinnitus (CN VIII). Chronic use can lead to acute renal failure, interstitial
nephritis, GI bleeding. Risk of Reye syndrome in children treated with aspirin for viral infection.

Answer 3

ASA

Question 4

Causes respiratory alkalosis early, but transitions to mixed metabolic acidosis-respiratory alkalosis.

Answer 4

ASA

Question 5

Reversibly inhibits specifically the cyclooxygenase (COX) isoform 2,

Answer 5

Celecoxib

Question 6

helps maintain gastric mucosa.

Answer 6

Cox 1

Question 7

found in

inflammatory cells and vascular endothelium and mediates inflammation and pain;

Answer 7

Cox 2

Question 8

spares

COX-1, which helps maintain gastric mucosa.

Answer 8

Celecoxib

Question 9

Spares platelet function as TXA2 production is dependent on COX-1.

Answer 9

Celecoxib

Question 10

Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac, meloxicam, piroxicam.

Answer 10

NSAIDS

Question 11

Reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin synthesis.

Answer 11

NSAIDS

Question 12

Antipyretic, analgesic, anti-inflammatory. Indomethacin is used to close a PDA.

Answer 12

NSAIDS

Question 13

inhibit leukotriene receptor

Answer 13

montelukast, zafirlukast

Question 14

Reversibly inhibits cyclooxygenase, mostly in the CNS

Answer 14

acetaminophen

Question 15

inhibits chemotaxis, phagocytosis and degranulation. Also reduces formation of LTB4

Answer 15

colchicine

Question 16

inhibit leukotriene synthesis

Answer 16

zileuton

Question 17

inhibit phospholipase A 2

Answer 17

glucocorticoids (corticosteroids)

Question 18

increase bronchial tone

Answer 18

leukotrienes (LTC4, LTD4, LTE4)

Question 19

increase neutrophil chemotaxis

Answer 19

LTB4

Question 20

decrease platelet aggregation

Answer 20

PGI2

Question 21

decrease vascular tone

Answer 21

prostacyclin, prostaglandin

Question 22

increase uterine tone

Answer 22

PGE2, PGF2A

Question 23

Increase platelet aggregation and increase vascular tone

Answer 23

TXA2

Question 24

Antipyretic, analgesic, but not anti-inflammatory. Used instead of aspirin to avoid Reye syndrome
in children with viral infection.

Answer 24

acetaminophen

Question 25

N-acetylcysteine is antidote—regenerates glutathione

Answer 25

acetaminophen overdose

Question 26

Reversibly inhibits dihydroorotate dehydrogenase, preventing pyrimidine synthesis. Suppresses T-cell proliferation

Answer 26

leflunomide

Question 27

Pyrophosphate analogs; bind hydroxyapatite in bone, inhibiting osteoclast activity.

Answer 27

Bisphosphonates

Question 28

Alendronate, ibandronate, risedronate, zoledronate.

Answer 28

Bisphosphonates

Question 29

Recombinant PTH analog given subcutaneously daily. increase􀁱 osteoblastic activity

Answer 29

Teriparatide

Question 30

Recombinant uricase that catalyzes metabolism of uric acid to allantoin.

Answer 30

rasburicase

Question 31

All____________ predispose to infection, including reactivation of latent TB, since TNF is important in granuloma formation and stabilization

Answer 31

TNF-α inhibitors

Question 32

``` Fusion protein (receptor for TNF-α + IgG1 Fc), produced by recombinant DNA. ```

Answer 32

entanercept

Question 33

anti-TNF alpha monoclonal Antibody

Answer 33

infliximab, adalimumab

Question 34

Competitive inhibitor of xanthine oxidase. decrease􀁲 conversion of hypoxanthine and xanthine to urate.

Answer 34

allopurinol

Question 35

Inhibits xanthine oxidase.

Answer 35

febuxostat

Question 36

Recombinant uricase that catalyzes metabolism of uric acid to allantoin (a more water-soluble product).

Answer 36

pegloticase

Question 37

Inhibits reabsorption of uric acid in proximal convoluted tubule (also inhibits secretion of penicillin). Can precipitate uric acid calculi.

Answer 37

probenecid

Question 38

Naproxen, indomethacin. Do not give salicylates; all but the highest doses depress uric acid clearance. Even high doses (5–6 g/day) have only minor uricosuric activity.

Answer 38

NSAIDS

Question 39

acute gout drugs

Answer 39

NSAIDS, glucocorticoids, colchicine

Question 40

Binds and stabilizes tubulin to inhibit microtubule polymerization, impairing neutrophil chemotaxis and degranulation. Acute and prophylactic value. GI side effects.

Answer 40

colchicine

Question 41

PABA esters are used on what type of UV radiation?

Answer 41

UVB only

Question 42

What is a major cause of sunburns?

Answer 42

UVB

Question 43

what causes skin photo agin, photo carcinogenesis, UVR induced immunosuppression, histologic skin damage?

Answer 43

UVB