Psych

Question 1

ADHD

Answer 1

Stimulants (methylphenidate, amphetamines)

Question 2

Alcohol withdrawal

Answer 2

Benzodiazepines (eg, chlordiazepoxide,

lorazepam, diazepam)

Question 3

Bipolar disorder

Answer 3

Lithium, valproic acid, atypical antipsychotics

Question 4

Bulimia nervosa

Answer 4

SSRIs

Question 5

Depression

Answer 5

SSRIs

Question 6

Generalized anxiety disorder

Answer 6

SSRIs, SNRIs

Question 7

Obsessive-compulsive disorder

Answer 7

SSRIs, venlafaxine, clomipramine

Question 8

Panic disorder

Answer 8

SSRIs, venlafaxine, benzodiazepines

Question 9

PTSD

Answer 9

SSRIs, venlafaxine

Question 10

Schizophrenia

Answer 10

Atypical antipsychotics

Question 11

Social anxiety disorder

Answer 11

SSRIs, venlafaxine

Performance only: β-blockers, benzodiazepines

Question 12

Tourette syndrome

Answer 12

Antipsychotics (eg, fluphenazine, pimozide),

tetrabenazine

Question 13

CNS stimulants MOA

Answer 13

increase􀁱 catecholamines in the synaptic cleft, especially norepinephrine and dopamine.

Question 14

Neuroleptic malignant syndrome (NMS)

Answer 14

—
rigidity, myoglobinuria, autonomic instability,
hyperpyrexia.

Question 15

MOA:
block dopamine D2
receptors (increase􀁱 [cAMP]).

Answer 15

Antipsychotics

Question 16

Haloperidol, trifluoperazine, fluphenazine, thioridazine, chlorpromazine (haloperidol + “-azines”).

Answer 16

antipsychotics

Question 17

High potency: Trifluoperazine, Fluphenazine,

Haloperidol (Try to Fly High)—cause:

Answer 17

neurologic
side effects (eg, extrapyramidal symptoms
[EPS]).

Question 18

Aripiprazole, asenapine, clozapine, iloperidone, lurasidone, olanzapine, paliperidone, quetiapine,
risperidone, ziprasidone.

Answer 18

atypical antipsychotics

Question 19

Side effect of clozapine

Answer 19

agranulocytosis (monitor WBC

weekly).

Question 20

SE of -pines

Answer 20

metabolic syndrome (weight gain,
diabetes, hyperlipidemia).

Question 21

SE of risperidone

Answer 21

hyperprolactinemia (amenorrhea,

galactorrhea, gynecomastia).

Question 22

Se of olanzapine

Answer 22

obesity: monitor the lipid panel and fasting glucose

Question 23

buspirone MOA:

Answer 23

Stimulates 5-HT1A receptors..

Takes 1–2
weeks to take effect. Does not interact with
alcohol (vs barbiturates, benzodiazepines).

Question 24

SSRI MOA:

Answer 24

5-HT–specific reuptake inhibitors.

Question 25

Fluoxetine, paroxetine, sertraline, citalopram

Answer 25

SSRI

Question 26

MC SE of SSRI

Answer 26

sexual dysfunction

Question 27

Venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, milnacipran

Answer 27

SNRI

Question 28

SNRI MOA

Answer 28

Inhibit 5-HT and norepinephrine reuptake

Question 29

MC SE of SNRI

Answer 29

increase blood pressure

Question 30

Serotonin Syndrome

Answer 30

Can occur with any drug that increases 5-HT (eg, MAO inhibitors, SNRIs, TCAs). Characterized by 3 A’s: neuromuscular Activity (clonus, hyperreflexia, hypertonia, tremor, seizure), Autonomic stimulation (hyperthermia, diaphoresis, diarrhea), and Agitation.

Question 31

Amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine

Answer 31

TCAs

Question 32

TCAs MOA:

Answer 32

Block reuptake of norepinephrine and 5-HT.

Question 33

What can happen with TCAs?

Answer 33

Tri-C’s: Convulsions, Coma, Cardiotoxicity (arrhythmia due to Na+ channel inhibition); also respiratory depression, hyperpyrexia.

Question 34

Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline

Answer 34

MAO inhibitors

Question 35

MAO inhibitor MOA

Answer 35

Nonselective MAO inhibition 􀁱 increase levels of amine neurotransmitters (norepinephrine, 5-HT, dopamine).

Question 36

Atypical depression= mood reactivity, leaden paralysis (heavy arms/legs), rejection sensitivity (get butt hurt), increased sleep and appetite

Answer 36

MAO inhibitor used

Question 37

Contraindicated with SSRIs, TCAs, St. John’s wort, | meperidine, dextromethorphan to prevent?

Answer 37

serotonin syndrome

Question 38

bupropion MOA

Answer 38

􀁱increase norepinephrine and dopamine

Question 39

Mirtazapine MOA:

Answer 39

α2-antagonist (􀁱 release of NE and 5-HT), potent 5-HT2 and 5-HT3 receptor antagonist and H1 antagonist.

Question 40

Trazodone MOA

Answer 40

Primarily blocks 5-HT2, α1-adrenergic, and H1 receptors

Question 41

Varenicline MOA

Answer 41

Nicotinic ACh receptor partial agonist.

Question 42

MC toxicity with bupropion?

Answer 42

seizures in anorexic/bulimic patients

Question 43

MC toxicity with mirtazapine?

Answer 43

increase appetite and weight gain. Give to old ladies that are depressed and won't eat or give to those that are depressed but not sleeping well ( due to sedation effects)

Question 44

MC SE of trazadone?

Answer 44

priapism

Question 45

MC SE of varenicline?

Answer 45

sleep disturbances

Question 46

1st line treatment for major depressive disorder that does not cause sexual dysfunction

Answer 46

bupropion

Question 47

MAO type B inhibitor that is given to prevent MPTP associated parkinsoniam type symptoms

Answer 47

Selegiline

Question 48

used to treat delirium

Answer 48

Haloperidol or other low dose antipsychotic

Question 49

All antidepressants carry the risk of inducing what? in susceptible patients.

Answer 49

mania

Question 50

What drug is used in treatment resistant schizophrenia?

Answer 50

clozapine

Question 51

TCA's inhibit _______channel conduction, slowing down myocardial depolarization and leading to cardiac arrhythmias.

Answer 51

Sodium

Question 52

What is the MCC of death in patients with TCA overdose?

Answer 52

cardiac arrhythmias

Question 53

Nonbenzodiazepine anxiolytic used to treat generalized anxiety disorder that has a slow onset of action, lacks muscle relaxant, or anticonvulsant properties, and carries no risk of dependence

Answer 53

buspirone

Question 54

patient has depression, fatigue, hypersomnia, vivid dreams. What is this patient withdrawing from?

Answer 54

cocaine

Question 55

Left side frontal lobe lesions are associated with?

Answer 55

apathy and depression

Question 56

right sided frontal lobe lesions are associated with?

Answer 56

disinhibited behavior

Question 57

Methadone is great for treating opioid abuse because it has?

Answer 57

has a long half life

Question 58

Full mu-opioid receptor agonist to control chronic pain and in opioid withdrawal and maintenance treatment of addiction?

Answer 58

methadone