Mucosal Immunity Flashcards Preview

GI II Exam 1 > Mucosal Immunity > Flashcards

Flashcards in Mucosal Immunity Deck (35):
1

IgA

mucosal surface immunity

2

innate immunity of GI

goblet cells - mucous
epithelial cells - barrier
paneth cells - antibacterial
M cells - antigen sampling

3

adaptive immunity of GI

IgA - anti-inflammatory
Th17 - IL-17 and IL-22
suppression of cell-mediated immunity - T regs

4

FoxP3

T reg cell
-inhibit immune responses

5

CD103

dendritic cells

6

cytokines of adaptive immunity

TGF-beta
IL-10
IL-2

7

celiac disease

deficient fox-p3 cells
-no T regs to inhibit response

8

stratification

minimize contact between bacteria and epithelium

mucous

9

compartmentalization

confine bacteria to intestinal sites and limiting systemic exposure

-phagocytes in lamina propria
-homing lymphocytes to mucosal surfaces

10

abnormalities in inflammatory bowel disease

dysregulated innate immunity

abnormal cell mediated immunity - overactive Th17

defect T regs

defective autophagy

11

NLR

PAMP recognition
-in cytoplasm*

12

crohns disease susceptibility gene

NOD2

is an NLR

13

food allergies

IgE mediated
-food specific IgE - mast cells
-young children

non IgE mediated
-Th2 response - skin/GI sx
-eosinophilic disorders

14

induction of tolerance in gut

CD103 dendritic cells

TGF-beta

retinoic acid

all 3 to stimulate foxp3 T reg cells

15

events in immediate hypersensitivity

allergen exposure
-Th2 activation and IgE class switch
-B cells make IgE
-IgE activate mast cells

repeat exposure
-IgE activate mast cells

release of vasoactive amines and cytokines occurs**

16

immediate hypersensitivty rxns

vasoactive amines
lipid mediators

17

late phase rxn

cytokines - hours after exposure

18

why food allergies

inappropriate digestion hypothesis

-di and tri peptides don't cause immune response
-longer peptides result in immune response**

19

celiac disease

T cell mediated
-with other autoimmune disease

sx-abdominal pain, growth failure, anemia, osteoporosis

20

Abs to tissue transglutaminase

celiac disease

Abs are IgA

useful for diagnosis

21

celiac genetics

HLA-DQ2 or DQ8

necessary, but not sufficient to develop disease

22

celiac path

tissue response is to de-aminated gluten

damage is due to the T cells

antibodies - useful for diagnosis

23

gliadin

breakdown of gluten

resistant to protelytic digestion by GI proteases

24

celiac disease antibodies

tissue transglutaminase

endomysium

gliadin

deamidated gliadin

25

marsh score

villous atrophy in celiac

with increase TG levels - see more villous atrophy

26

diagnosis of celiac

biopsy and Abs for TG

27

TG autoantibodies

takes years for this to decrease even after a gluten free diet with celiac disease

28

enzyme therapy for celiac

digest gliaden

29

zonulin antagonist

celiac tx

protein increasing intestine permeability

30

IPEX

immune dysregulation, polyendocrinpathy, enteropathy X-linked disease

mutation in Foxp3

loss of T reg cells**

widespread autoimmunity

sx - watery diarrhea, failure to thrive, diarrhea, autoimmune diabetes

elevated IgE

31

foxp3 mutation

IPEX

32

autoimmune disease with elevated IgE

think IPEX

33

IL-10

suppreses IgE production

34

TGF-beta

inhibits IgE production

35

T reg cell activity

suppress Th1 and Th2 cells

suppress IgE - by inducing IL-10 and TGF-beta