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Flashcards in multiple myeloma Deck (10):
1

what is multiple myeloma 

  • a malignancy of plasma cells
    • replace bone marrow
    • destroy bone
    • can form tumors

2

In multiple myeloma, plasma cells secrete what that create hyperviscosity and renal failure 

paraproteins (abnormal immunoglobulin fragments) 

3

In multiple myeloma, as the plasma cells replace bone, what signs and symptoms occur

  • pancytopenia: deficiency of all three cellular components of the blood (red cells, white cells, and platelets)
  • bone pain
  • osteoporosis
  • hypercalcemia 

4

diagnosis of multiple myeloma

  1. protein elecrophoresis on blood or urine shows paraproteins
    • see M-spike (Monoclonal spike)
  2. Bence Jones proteins in urine 

5

multiple myeloma is more common in what ethnicity 

african americans 

6

multiple myeloma presents with pain in what two main areas without any h/o trauma 

  • back pain
  • bone pain 

7

What is hyperviscosity syndrome (caused by paraproteins) causes what symptoms 

  • spontaneous bleeding from mucous membranes
  • visual disturbances due to retinopathy
  • neurologic symptoms 
    • HA
    • vertigo
    • sz
    • coma

8

bence jones proteins in urine are indicative of what disease 

multiple myeloma

9

What diagnostic study results are indicative of multiple myeloma

CRAB

  • Calcium > 10.5
  • Renal insufficiency (Cre > 2)
  • Anemia (Hbg < 10)
  • Bone lesions 

10

treatment of multiple myeloma

IV bisphosphonates