Flashcards in Muscarinic Receptor Antagonists-T1 Deck (11):
12 selective muscarinic receptor antagonists
- tiotropium (spiriva)
- solifenacin (vesicare)
- darifenacin (enablex)
3 non selective muscarinic receptor antagonists
Atropine is a ___ of the muscarinic receptor
competitive antagonist. it does not differentiate between the 5 muscarinic receptor subtypes.
CNS effects from muscarinic receptor antagonists
-small doses may cause increase vagal nerve activity
- high doses make you act crazy
cardiovascular effects from muscarinic receptor antagonists
-low doses may initially decrease HR, due to CNS effects that stimulate vagus nerve and as dose increases,block muscarinic receptors, followed by increases in heart rate---- blockade of M2 receptors on pacemaker and conduction cells.
- cutaneous blood vessels are dilated by atropine
respiratory effects of muscarinic receptor antagonists
leads to bronchodilation and decreased bronchial secretions.. increase airflow
GI effects of muscarinic receptor antagonists
decreased salivary secretions, decreased gastric secretions, decreased gastric motility-- may be useful for diarrhea
urinary tract effects of muscarinic receptor antagonists
relaxation of ureter and bladder smooth muscle; decreases voiding action leads to urinary rentention.
sweating effects of muscarinic receptor antagonists
sweating controlled by sympathetic, cholinergic innervation is abolished by muscarinic receptor blockade
vision effects of muscarinic receptor antagonists
loss in accommodation and dilation of iris sphincter.