Muscarinic Receptor Antagonists-T1 Flashcards Preview

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Flashcards in Muscarinic Receptor Antagonists-T1 Deck (11)
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1
Q

12 selective muscarinic receptor antagonists

A
  • atropine
  • hyoscamine
  • ipatropium
  • tiotropium (spiriva)
  • tolterodine (detrol)
  • oxybutynin
  • solifenacin (vesicare)
  • scopolamine
  • glycopyrrolate
  • darifenacin (enablex)
  • cyclopentolate
  • benztropine (cogentin)
2
Q

3 non selective muscarinic receptor antagonists

A
  • amitriptyline
  • dicyclomine
  • benadryl
3
Q

Atropine is a ___ of the muscarinic receptor

A

competitive antagonist. it does not differentiate between the 5 muscarinic receptor subtypes.

4
Q

CNS effects from muscarinic receptor antagonists

A
  • small doses may cause increase vagal nerve activity

- high doses make you act crazy

5
Q

cardiovascular effects from muscarinic receptor antagonists

A
  • low doses may initially decrease HR, due to CNS effects that stimulate vagus nerve and as dose increases,block muscarinic receptors, followed by increases in heart rate—- blockade of M2 receptors on pacemaker and conduction cells.
  • cutaneous blood vessels are dilated by atropine
6
Q

respiratory effects of muscarinic receptor antagonists

A

leads to bronchodilation and decreased bronchial secretions.. increase airflow

7
Q

GI effects of muscarinic receptor antagonists

A

decreased salivary secretions, decreased gastric secretions, decreased gastric motility– may be useful for diarrhea

8
Q

urinary tract effects of muscarinic receptor antagonists

A

relaxation of ureter and bladder smooth muscle; decreases voiding action leads to urinary rentention.

9
Q

sweating effects of muscarinic receptor antagonists

A

sweating controlled by sympathetic, cholinergic innervation is abolished by muscarinic receptor blockade
“atropine fever”

10
Q

vision effects of muscarinic receptor antagonists

A

loss in accommodation and dilation of iris sphincter.

11
Q

make sure to review therapeutic uses of specific agents

A

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