Muscarinic Receptor Antagonists-T1 Flashcards Preview

PHAR417 > Muscarinic Receptor Antagonists-T1 > Flashcards

Flashcards in Muscarinic Receptor Antagonists-T1 Deck (11):
1

12 selective muscarinic receptor antagonists

- atropine
- hyoscamine
-ipatropium
- tiotropium (spiriva)
-tolterodine (detrol)
- oxybutynin
- solifenacin (vesicare)
- scopolamine
- glycopyrrolate
- darifenacin (enablex)
- cyclopentolate
-benztropine (cogentin)

2

3 non selective muscarinic receptor antagonists

- amitriptyline
-dicyclomine
- benadryl

3

Atropine is a ___ of the muscarinic receptor

competitive antagonist. it does not differentiate between the 5 muscarinic receptor subtypes.

4

CNS effects from muscarinic receptor antagonists

-small doses may cause increase vagal nerve activity
- high doses make you act crazy

5

cardiovascular effects from muscarinic receptor antagonists

-low doses may initially decrease HR, due to CNS effects that stimulate vagus nerve and as dose increases,block muscarinic receptors, followed by increases in heart rate---- blockade of M2 receptors on pacemaker and conduction cells.
- cutaneous blood vessels are dilated by atropine

6

respiratory effects of muscarinic receptor antagonists

leads to bronchodilation and decreased bronchial secretions.. increase airflow

7

GI effects of muscarinic receptor antagonists

decreased salivary secretions, decreased gastric secretions, decreased gastric motility-- may be useful for diarrhea

8

urinary tract effects of muscarinic receptor antagonists

relaxation of ureter and bladder smooth muscle; decreases voiding action leads to urinary rentention.

9

sweating effects of muscarinic receptor antagonists

sweating controlled by sympathetic, cholinergic innervation is abolished by muscarinic receptor blockade
"atropine fever"

10

vision effects of muscarinic receptor antagonists

loss in accommodation and dilation of iris sphincter.

11

make sure to review therapeutic uses of specific agents

ksdhfj