T1-Drugs Flashcards Preview

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Flashcards in T1-Drugs Deck (59):
1

Acetylcholine

cholinergic agonist- muscarinic miosis(pupil constriction) during surgery

2

carbachol

cholinergic agonist- muscarinicmiosis(pupil constriction) during surgery

3

bethanechol

cholinergic agonist- muscarinic. improve poor bladder tone and increase GI motility

4

methacholine

cholinergic agonist- muscarinic. used for asthma test

5

pilocarpine

cholinergic agonist- muscarinic. reduce IOP in open angle glaucoma

6

cevimeline

cholinergic agonist- muscarinic. dry mouth

7

chantix

cholinergic agonist- nicotinic. stop smoking

8

atropine

selective muscarinic antagonist: mydriases(dilate iris) and thicken lens.
- decrease mucosal secretion
- increase BP
-increase HR
-overactive bladder
- muscarinic agent or cholinesterase inhibitor poisoning treatment

9

hyoscyamine

selective muscarinic antagonist

10

ipratropium

selective muscarinic antagonist: bronchodilation in asthma

11

tiotropium (spiriva)

selective muscarinic antagonist:

12

tolterodine (detrol)

selective muscarinic antagonist: urinary urgency

13

oxybutynin

selective muscarinic antagonist: urinary urgency

14

solifenacin (vesicare)

selective muscarinic antagonist: urinary urgency

15

benztropine (cogentin)

selective muscarinic antagonist: parkinsons

16

scopolamine

selective muscarinic antagonist:

17

glycopyrrolate

selective muscarinic antagonist

18

darifenacin (enablex)

selective muscarinic antagonist

19

cyclopentolate

selective muscarinic antagonist

20

amitriptyline

nonselective muscarinic antagonist

21

dicyclomine

nonselective muscarinic antagonist

22

benadryl

nonselective muscarinic antagonist

23

ambenonium

cholinesterase inhibitor

24

demecarium

cholinesterase inhibitor

25

donepezil

cholinesterase inhibitor

26

echothiophate

irreversible cholinesterase inhibitor. treats glaucoma

27

galantamine

cholinesterase inhibitor

28

malathione

irreversible cholinesterase inhibitor

29

DFP

irreversible cholinesterase inhibitor for glaucoma

30

neostigmine

semi reversible cholinesterase inhibitor for glaucoma, and MG therapy

31

physostigmine

reversible cholinesterase inhibitor for glaucoma and atropine toxicity

32

pyridostigmine

semi reversible cholinesterase inhibitor for MG

33

rivastigmine (exelon)

cholinesterase inhibitor

34

tacrine

cholinesterase inhibitor

35

edrophonium (tensilon)

reversible cholinesterase inhibitor for diagnosing and dose assessment of MG

36

soman

irreversible cholinesterase inhibitor

37

tabun

irreversible cholinesterase inhibitor

38

pralidoxime (2-PAM)

cholinesterase regenerator

39

atracurium

non depolarizing nicotinic antagonist

40

doxacurium

non depolarizing nicotinic antagonist

41

mivacurium

non depolarizing nicotinic antagonist

42

pancuronium

non depolarizing nicotinic antagonist

43

rocuronium

non depolarizing nicotinic antagonist

44

tubocurarine

non depolarizing nicotinic antagonist

45

dantrolene

non depolarizing nicotinic antagonist

46

d-tubocurarine

non depolarizing nicotinic antagonist

47

vencuronium

non depolarizing nicotinic antagonist

48

succinylcholine

depolarizing nicotinic antagonist

49

decamethonium

depolarizing nicotinic antagonist

50

general receptor effects of cholinergic agonist

- decrease HR and BP
- increase GI motility
-pupil constriction
-increase secretion
- bronchial constriction

51

general receptor effects muscarinic antagonists :CNS

-increase vagal nerve activity

52

general receptor effects muscarinic antagonist: cardio

- decrease HR initially b/c of vagal nerve stimulation. eventually blocking of M2 receptors cause an increase in BP

53

general receptor effects muscarinic antagonist: respiratory

-bronchodilation

54

general receptor effects muscarinic antagonist: GI

- decrease in:
salivation, gastric secretion, and GI motility

55

general receptor effects muscarinic antagonist: urinary

urine retention (relaxed ureter and bladder smooth muscle)

56

general receptor effects muscarinic antagonist: sweating

atropine fever

57

general receptor effects cholinesterase

-decrease HR
-decrease BP
- increase Gi motility
- pupil constriction
- increase then decrease in IOP
- increase in secretions
-bronchial constriction

58

general receptor effects depolarizing nicotinic antagonist

-activation receptors to cause Na influx, causing partial depolarization and contraction.
- when Ach activates the receptor further, flaccid paralysis can occur
-the partially depolarized motor end plate results in inactive nicotinic channels and Ach cannot repolarize

59

general receptor effects non depolarizing nicotinic antagonist

- 2 Ach binds to nicotinic receptor to activate. if 1 is antagonist, the activity is decreased
- can be reversed by cholinesterase inhibitors