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1

Treatment for VRE? is it gram pos or neg?
pertinent characteristics?

+
1. Linezolid (oxazolidinones- 50s)
2. Tigecycline (Tetracycline derivative- 30s)
3. Daflospristin/quinupristin (Streptogramin-50s) *for life-threatening VRE

2

Treatment for MRSA? is it gram pos or neg?
pertinent characteristics?

+
1.Vancomycin (glycopeptide- MOA cell wall DALADALA, Toxicities: Nephrotox, Ototox, Thrombocytopenia)
2. Daptomycin (cell membrane)- endocarditis, sepsis
3. Linezolid (oxalidinones 30s)
4. Tigecycline (Tetracycline derivative-30s)
5. Ceftaroline (5th gen ceph)

3

Antimicrobial to avoid when pregnant

"SAFe Children Treatment"
Sulfonamides - Kernicterus, neural tube defects
Aminoglycosides - Ototoxicity
Fluoroquinolones - Cartilage damage
Clarithromycin - Embryo toxic
Tetracyclines - Discolored teeth/inhibit bone growth

4

Treatment for active TB: two phases and the drugs

intensive: 2 months antimycobaterials :
Isoniazid
Rifampin
Pyrazinamide
Ethambutol

latent: 4 months antimycobacterials
Isoniazid
Rifampin

5

Gram pos or neg? and treatment?... H.Flu

Neg.
1. 2nd and 3rd Gen Cephalosporins

6

gram pos or neg? and treatment?... S. pneumoniae

+
1. Linezolid (Oxazolindenone- 50s subunit)
- treats HAP, CAP
2. Levofloxacin (Fluoroquinolones- DNAsynthesis)
- treats URI including S. Pneumonia

7

gram pos or neg? and treatment? ...E. Coli
- category and major pertinent traits of each option

Neg.
1. Amp/Amox (extended spec. PCN)
2. 1st and 2nd Gen Cephs
3. Polymixins (cell membrane, treat gram neg. exclusively)
4. Aminoglycosides (30s subunit) - only serious infections, IV, IM, topical only- Teratogen
5. FluroQ- (DNA synth)- major adverse effects, major cause Cdiff
6. Nitrofurantoin (ribosome synth) use for UTIs

8

gram pos or neg? and treatment?...MSSA?
pertinent traits of each

"MiSSA, TriMe...i is Anti Staff"
1. Anti-staph PCN
2. Trimethoprim (Folate synthesis- PABA)
-->clinical: alone- simple UTI, w/ Sulfamethaxole...PJP opportunistic HIV pneumonia, MSSA, MRSA, etc
Tox: TMP"Treats Marrow Poorly"

9

treatment of anaerobic cocci/rods?
pertinent characteristics of each?

1.Clindamycin (50s subunit- anaerobes ABOVE diaphragm)
2.Metronidazole (DNA- anaerobes BELOW diaphragm)
3.Moxifloxacin (DNA-FluroQ): GREAT absorption, lots of adverse effects, MAJOR cause of CDiff)
4.Amox/clav: (BetaLac inhibitor)
5.Pipercillin/Tazo and Ticarcillin/Clav (extended spectrum PCN w/ BetaLac inhibitor)
6. Miro, Imi, and Erta penem (carbopenems) (BROADest of BetaLactams)

10

por or neg? treatment? ... Cdiff
pertinent characteristics of each

+
1. Vancomycin (oral): (cell wall DALADALA glycopeptides group)
Tox: NephroTox, Ototox, Thrombocytopenia)
2. Metronmidazole (aka flagyl) (DNA) - BELOW diaphragm anaerobe treatment,
Tox: Disulfuram Rxn

11

B. Burgdorferi treatment?

spirochete: lyme's disease
1. Doxycycline (30s tetracycline- fecal elimination)
2. Amoxicillin (extended spectrum PCN)
3. 2nd and 3rd cephalosporin

12

what gets CAP?

ceforoxime (2nd gen) (...comes from H Flu)

13

what gets HAP?

ceftazidime (3rd gen) (...comes from pseudomonas)