Myasthenia Gravis

Question 1

myasthenia gravis

Answer 1

Autoimmune disorder

Fluctuating weakness of certain muscle groups

Question 2

course of disease

Answer 2

Short term remission
Stabilization
Severe, progression

Question 3

risk factors

Answer 3

10 to 65 years old
Females

Question 4

patho

Answer 4

anti-ACH antibodies attack ACH receptors

Decreased ACH receptor sites at neuromuscular junction

Prevents ACH molecules from attaching to and stimulating muscle contraction

Question 5

s/sx

Answer 5

fluctuating weakness in skeletal muscles

Muscles – eyes, face
Difficulty speaking, breathing

Question 6

T/F myasthenia gravis has an insidious onset

Answer 6

True

Question 7

what occurs after rest with myasthenia gravis?

Answer 7

Strength comes back

Question 8

myasthenia gravis crisis

Answer 8

Acute exacerbation of muscle weakness

Not enough ACH

Question 9

Triggers of MG crisis

Answer 9

infection
Surgery
Emotional distress
Pregnancy, Menses
Inadequate pharm therapy

Question 10

major complications of crisis

Answer 10

Breathing muscle weakness
Respiratory distress

Question 11

pharm

Answer 11

immunosuppressants
Steroids
Cholinesterase inhibitors

Question 12

are cholinesterase inhibitors a cure or symptom relief

Answer 12

Symptom relief

Question 13

Cholinergics

Answer 13

Increased G.I. motility, diarrhea
Increase secretions
Bladder urgency
Bradycardia
Bronchial constriction
Miosis – construction

Question 14

Anti-cholinergics

Answer 14

Decreased motility, constipation
Dry mouth
Urinary retention
Tachycardia
Bronchodilation
Mydriasis – dilation

Question 15

cholinergic crisis

Answer 15

Extreme muscle weakness/paralysis
Smooth muscle overexcited ability
Too much ACH or nystigmine

Question 16

Treatment for cholinergic crisis

Answer 16

mechanical ventilation
Antidote – atropine

Question 17

What to do to distinguish between MG and cholinergic crisis

Answer 17

give edrophonium

If symptoms improve – MS crisis
If symptoms worsen – cholinergic crisis