Neisseria Flashcards

1
Q

a 14-year-old girl who was sent home from school because she had a fever of 38Β°C, a severe headache, neck stiffness, and was falling asleep in class. When her fever rose to 40Β°C, her mother took her to the emergency room, where a blood pressure of 60/20 and several petechial hemorrhages were found. Gram-negative diplococci were seen in a Gram stain of the spinal fluid.
β€’ What is the causative agent?

A

Neisseria

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2
Q

a 14-year-old girl who was sent home from school because she had a fever of 38Β°C, a severe headache, neck stiffness, and was falling asleep in class. When her fever rose to 40Β°C, her mother took her to the emergency room, where a blood pressure of 60/20 and several petechial hemorrhages were found. Gram-negative diplococci were seen in a Gram stain of the spinal fluid.
β€’ What is the diagnosis?

A

Meningitdis

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3
Q

a 14-year-old girl who was sent home from school because she had a fever of 38Β°C, a severe headache, neck stiffness, and was falling asleep in class. When her fever rose to 40Β°C, her mother took her to the emergency room, where a blood pressure of 60/20 and several petechial hemorrhages were found. Gram-negative diplococci were seen in a Gram stain of the spinal fluid.

What is the most likely virulence factor to cause the fever,
hypotension, and petechial hemorrhages?

A

Endotoxin , only with gram negative cocci

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4
Q

a 14-year-old girl who was sent home from school because she had a fever of 38Β°C, a severe headache, neck stiffness, and was falling asleep in class. When her fever rose to 40Β°C, her mother took her to the emergency room, where a blood pressure of 60/20 and several petechial hemorrhages were found. Gram-negative diplococci were seen in a Gram stain of the spinal fluid.

What is the best diagnostic test?

A

CSF

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5
Q

a 14-year-old girl who was sent home from school because she had a fever of 38Β°C, a severe headache, neck stiffness, and was falling asleep in class. When her fever rose to 40Β°C, her mother took her to the emergency room, where a blood pressure of 60/20 and several petechial hemorrhages were found. Gram-negative diplococci were seen in a Gram stain of the spinal fluid.
tratment ?

A

Penicillin G

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6
Q

Neisseria are

A

gram-negative cocci that resemble paired kidney beans.

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7
Q

Oxiditive test result of neisseria

A

Positive

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8
Q

Species of neisseria ?

A

Neisseria meningitidis
Neisseria gonorrhoeae

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9
Q

Portal of entery for N. Meningitdis ?

A

Droplet from respiratory tract

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10
Q

Portal of entery for N. gonorrhoeae

A

Genital tract

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11
Q

Presence of polysaccharides capsule for Neisseria meningitidis

A

Positive

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12
Q

Presence of polysaccharides capsule for Neisseria gonorrhoeae

A

Negative

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13
Q

Result of maltose fermentation of Neisseria meningitidis?

A

Positive

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14
Q

Results of maltose fermintaion Neisseria gonorrhoeae?

A

Negative

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15
Q

Most common cause of meningitis in between the ages of 2 and 18
years

A

Neisseria meninigitdis

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16
Q

more than 80% of cases of bacterial meningitis in infants older than 2
months of age:

A

Streptococcal pneumonia, and neisseria meningitdis

17
Q

Role of polysaccharide capsule:

A

Antiphagocytic action

18
Q

Five serotypes of polysaccharides cpasule cause most cases of meningitis and meningococcemia:

A

A,B,C,Y,W

19
Q

A virulance factor that causes fever, shock, and other pathophysiologic
changes. ?

A

Endotoxin

20
Q

A virulance factor that helps the bacteria attach to
the membranes of the upper respiratory tract by cleaving secretory
IgA.

A

IgA protase

21
Q

Virulance factor that act as an inhibitor of complement factor C3b

A

Factor H binding protein (FHBP)

22
Q

Virulance factor that resist phagocytosis by
polymorphonuclear leukocytes (PMNs).

A

Polysaccharides capsule

23
Q

The severe form of
meningococcemia: the life-
threatening
With high fever, shock,
widespread purpura,
disseminated intravascular
coagulation, thrombocytopenia,
and adrenal insufficiency

A

Waterhouse–Friderichsen
syndrome:

24
Q

Lab diagnosis of neisseria

A

smear and culture of blood and spinal fluid samples: gram-negative
cocci

25
Q

Rapid detection, detects capsular
polysaccharide in the spinal fluid

A

Latex agglutination test:

26
Q

treatment of choice for meningococcal infections.

A

Penicillin G

27
Q

the most common source of the organism neisseria gonorrhoeae

A

Genital tract infection
but anorectal and pharyngeal infections are important sources as well

28
Q

Neisseria gonorrhoeae
Has no polysaccharide capsule, instead: it has ?

A

Pillus protein

29
Q

mediate attachment to mucosal cell surfaces
and are antiphagocytic

A

Pili

30
Q

Endotoxin virulance factor of neisseria gonorrhoeae?

A

lipooligosaccharide contain lipid A

31
Q

Pili, Outer membrane proteins , IgA protease, endotoxin
Are considered

A

A virulance factor of neisseria gonorrhoeae

32
Q

Septic arthritis in sexually active adults.
Is commonly caused by

A

Disseminated gonococcal infections (DGI)

33
Q

Disseminated gonococcal infections (DGI) are difficult to diagnose using laboratory because

A

Organisim is not cultured in 50% of the cases

34
Q

Culture of neisseria gonorrhoeae

A

Thayer-Martin medium, which is a chocolate agar
containing antibiotics (vancomycin, colistin, trimethoprim, and
nystatin) to suppress the normal flora

35
Q

Diagnosis test detect the
presence of gonococcal nucleic acids in patient specimens.

A

Nucleic acid amplification test

36
Q

treatment of choice in uncomplicated gonococcal
infections

A

Ceftriaxone

37
Q

Mixed infection with gonorrhoeae are treated by

A

trachomatis are common,
azithromycin or doxycyclin