Neonatal and Geriatric Anesthesia Flashcards

1
Q

Why is neonatal respiratory rate 2-3 times higher than in adults? What effect will this have on induction with inhalant anesthetics?

A

Vt is the same as an adult (10-15 ml/kg) so the respiratory rate must be 2-3 times greater for minute volume to meet oxygen demand
High alveolar vent increases gas exchange

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2
Q

What happens to cardiac output if bradycardia occurs in a neonate?

A

Cardiac output decreases

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3
Q

Is an 8 week old puppy or kitten a neonate?

A

No, it is considered pediatric
Neonatal: birth to 2 weeks
Pediatric: 8-2 weeks
Beyond 8 weeks, they are considered miniature adults for anesthesia

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4
Q

An 8 week-old puppy has a mean arterial blood pressure of 55 mmHg during anesthesia. Is this puppy hypotensive?

A

No. This is normal for a puppy that is 8 weeks old. Puppies tend to have a lower MAP than adults.

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5
Q

Why are alpha-2 agonists such as xylazine or medetomidine not a particularly good agents in neonatal and pediatric patients?

A

Because these cause vasoconstriction, there will be an increased afterload and inability to deal with it at this age

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6
Q

Under what conditions should glucose-containing fluids be administered to young animals during anesthesia? Which glucose-containing solution would be least likely to result in water overload, diuresis, and dehydration?

A

They will only get glucose-containing fluids if they truly need glucose
½ strength LRS with 2.5% dextrose

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7
Q

Can injectable anesthetics be used in 6-8 week-old puppies and kittens? Why or why not?

A

Yes. They are now pediatrics rather than neonates and their neurological system is more developed

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8
Q

Do older animals generally require more or less anesthetic agent?

A

Less

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9
Q

Is the anesthesia duration for older animals generally longer or shorter for a specific anesthetic dose?

A

Longer

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10
Q

Does age by itself increase anesthetic risk? Why or why not?

A

No, biological and physiological age are more important than chronological age

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11
Q

Why might recovery from lipophilic anesthetics be prolonged in the older patient?

A

There is an increase in adipose tissue and an increase in total distribution volume for lipophilic drugs

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12
Q

Older animals are often borderline hypoxic (PaO2 60-80 mmHg) when awake. Why?

A

They have an increase in alveolar deadspace

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13
Q

Describe an easy, inexpensive physical method that you can use in a practice setting to determine whether an older animal has adequate cardiac reserve to undergo anesthesia.

A

Exercise challenge: take them out and run them around. If you get tired before the dog gets tired, they’re probably fine. If they have a hard time, then they have cardiac problems and should not undergo anesthesia

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14
Q

Why would drugs that cause the heart to beat faster (i.e. antimuscarinics, ketamine) not be good drugs for the older patient?

A

This will make them tachycardic and increase myocardial consumption causing arrhythmias

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15
Q

What is the O2 rate for neonates and pediatrics?

A

2-3 times greater than adults

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16
Q

What is respiratory control like at birth?

A

Immature

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17
Q

What are respiratory considerations for neonates and peds?

A

Increase risk of pulmonary shunting

Greater risk of airway obstruction

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18
Q

What are circulatory considerations for neonates and peds?

A
Neonatal circulatory system is low pressure, low volume, low peripheral resistance
Reduced myocardial contractility
Immature ANS
Resting CO near maximal
Reduced ventricular compliance
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19
Q

By how much do iso and sevo reduce BP?

A

20-30%

20
Q

How much do Hgb levels decrease by 2 weeks of age?

A

40%

21
Q

What does hematopoesis begin?

A

> 4 weeks

22
Q

What are metabolic considerations for neonates and peds?

A

Lower plasma albumin, larger % total body water, lower body fat, greater distribution CO to vessel-rich organs, reduced hepatic and renal function

23
Q

What are renal considerations for neonates and peds?

A

Neonatal dog kidney is immature at birth

Glomerular filtration matures between 2-3 week; tubular secretion between 4-8 weeks

24
Q

How do neonates thermoregulate?

A

Poikilothermic

25
Q

What likely happens to thermoregulation with anesthesia?

A

Hypothermia

26
Q

What does hypothermia result in?

A

Bradycardia
Decreased CO and BP
Promonged recovery due to reduced drug clearance

27
Q

What are anesthetic recommendations for neonates and peds?

A

Accurate body weight
Preoperative fasting is unnecessary
Administer an antimuscarinic
Most sedative/tranquilizers can be used cautiously
Opioid are well tolerated
Avoid injectable induction agents < 4 weeks of age
ISo and Sevo are preferred inhalants
LRS
Keep wasm and dry
Non-rebreathing circuits for patients < 5 kgs
Consider local anesthetics for awake procedures

28
Q

What happens to MAC as animals age?

A

It decreases

29
Q

What happens to the liver with age?

A

Hepatic processes are unchanged, but heptaic mass and blood flow are decreased

30
Q

What happens to the kidney with age?

A

Reduced renal mass, function, and reserve

31
Q

What happens to CO with age?

A

Progressively decreases

32
Q

What happens to contractility with age?

A

Relatively unchanged

33
Q

What is increase CO met though in geriatric patients?

A

Moderate increase in HR, SV, and LVEDV

34
Q

What happens to the autonomic reflexes with age?

A

Slower in onset
Less magnitude
Less effective in maintaining homeostasis

35
Q

What causes decreased response in geriatric patients?

A

Beta-adrenergic agents

36
Q

What causes unchanged responses in geriatric patients?

A

Muscarinic agents

Alpha-adrenergic receptor responses

37
Q

What is stage A of canine heart disease?

A

At risk of heart disease (CKCS without a murmur, so Sven)

38
Q

What is stage B1 of canine heart disease?

A

Signs of heart disease, but the dog is asymptomatic (a murmur with no structural changes)

39
Q

What is stage B2 of canine heart disease?

A

Signs of heart disease. the dog is asymptomatic (a murmur with structural changes, left atrial enlargement)

40
Q

What is stage C of canine heart disease?

A

Congestive heart failure is present or has been present and the dog is receiving treatment

41
Q

What is stage D of canine heart disease?

A

Congestive heart failure is present and refractory to standard therapies
Patient requires hospitalization

42
Q

What happens to lung elasticity and chest compliance as animals age?

A

They decrease

43
Q

What are the anesthetic recommendations for geriatric patients?

A

Pharmacologically, simple is best
Choose drugs that do not require extensive metabolism for termination of action or for which specific antagonists exist
Fix underlying issues before elective anesthesia

44
Q

What should be used as premeds in geriatric patients?

A

Opioids +/- low dose acepromazine or benzodiazepine
Alpha-2 agonists
Low dose ketamine in cats
Avoid antimuscarinics unless heart block or significant bradycardia is present

45
Q

What is used for induction of geriatric patients?

A

Suitable IV hypnotics include alfaxalone, etomidate, or propofol
Provide O2
Consider local anesthesia +/- sedation for minor procedures

46
Q

What is used for maintenance and recovery in geriatric patients?

A

Provide O2
Inhalant agents are preferred for long procedures
Propofol or alfaxalone CRI +/- opioid
Avoid hypotension
Avoid hypothermia, so work fast
Observe closely in recovery and provide heat if needed