Flashcards in Neonatal Sepsis Deck (8)
What is early onset neonatal sepsis?
Sepsis in the first 48-72 hours (3 days) of life
What are causes of neonatal sepsis? Organisms? Most common?
Ascending infection in mother with chorioamnionitis, via direct contact in the birth canal or haematological spread
Group B Streptococcus - Strep agalatctiae - most common
Coagulase negative staphylococcus - staph epidermis
How is neonatal sepsis prevented mothers?
Intrapartum IV antibiotics - ampicillin/penicillin/benzylpenicillin
Pyrexia during labour
What are risk factors for neonatal sepsis?
Invasive GBS infectino in previous baby
Maternal GBS colonisation, bacteruria or infection in current pregnancy
Prelabour rupture of membranes
Preterm birth following spontaneous labour (<37w)
Suspected or confirmed rupture of membranes more than 18h in preterm birth
Intrapartum fever higher than 38 or confirmed/suspected chorioamnionitis
What are clinical indicators suggestive of infeciton?
Feed intolverance - vomiting, abdominal distension
Signs of repisratory distress
Jaundice in 24h
Signs of neonatal encephalopathy
Mechanical ventilation in preterm baby
Altered glucose homeostasis
Signs of shock
Need for mechanical ventilation in term baby
RDS > 4h after birth
Suspected or confirmed infection in co-twin
Systemic ABX given to mother for suspected bacterial infection within 24h of birth
Swab/culture relevant sources - purulent eye discharge, foul smelling urine
LP for CSF if suspicion of meningitis