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Pathology I Test I > Neoplasia > Flashcards

Flashcards in Neoplasia Deck (250)
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1

What does neoplasia mean?

New Growth

2

What does tumor mean?

Swelling, formation of masses

3

What does cancer mean?

Tissue invasion appearance like crawling crab

4

What does oncology mean?

Study of Swelling

5

What does carcinoma in situ mean?

Means "in its place" but is a tumor that has not penetrated the basement membrane

6

Are all tumors a neoplasia?

Yes

7

Is a neoplasia always a tumor?

No, sometimes there's no distinct mass as in leukemia or malignant disease of bone marrow

8

What are the 3 types of reversible plasias?

1) Hyperplasia
2) Metaplsia
3) Dysplasia

9

What are the 3 types of irreversible plasias?

1) anaplasia
2) neoplasia
3) desmoplasia

10

What is anaplasia?

Irreversible Abnormal cells lacking differentiation; like primitive cells equated with undifferentiated malignant neoplasms

11

What is desmoplasia?

Irreversible Fibrous tissue formation in response to neoplasm

12

What are the two classifications of tumors?

Benign
Malignant

13

How are tumors classified?

Histologically

14

How do the growths of benign and malignant tumors differ?

Benign tumors are slow and expansive and malignant tumors are fast and invasive

15

Are both benign and malignant tumors metastatic?

No, Benign tumors are not metastatic

16

How do the external surface features of benign and malignant tumors differ?

Benign = smooth
Malignant = irregular

17

Do both benign and malignant tumors have capsules?

No, only benign tumors have capsules

18

Are both benign and malignant tumors capable of necrosis?

No, only malignant tumors are capable of necrosis

19

Are both benign and malignant tumors capable of hemorrhage?

No, only malignant tumors are capable of hemorrhage

20

How does the architechture of benign and malignant tumors differ?

Benign = resembles normal tissue of origin
Malignant = Does not resemble normal tissue of origin

21

How does the cells of benign and malignant tumors differ?

Benign = well differentiated
Malignant = Poorly differentiated

22

How do the nuclei of benign and malignant tumors differ?

Benign = normal size and shape; uniform
Malignant = pleomorphic (variable in shape)

23

How does the mitosis of benign and malignant tumors differ?

Benign = few in mitosis
Malignant = many and irregular

24

What is a regular nuclear to cytoplasmic ratio?

1:6

25

What does a nuclear to cytoplasmic ratio of 1:2 or 1:3 signify?

It means they are neoplastic

26

What does metastasis mean?

Change in position

27

What are the main pathways of metastasis?

1) lymphatics
2) blood (hematogenous spread)
3) Seeding surface of body cavities (transcoelomic spread)

28

What are some other pathways of metastasis?

Intraepithelial

29

What are the steps of hematogenous metastatic cascade?

1) primary tumor
2) metastatic clone evolves
3) proliferation of the clone and invasion of vessel
4) transport by circulation
5) emobilization
6) invasion
7) new tumor formation at the site of metastasis

30

What is transcoelomic spreading?

Direct seeding of a cavity by neoplastic cells within that cavity therefore there is no plane of resistance to spreading