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Flashcards in Neoplasia Deck (32):
1

What is P-selectin?

Cell adhesion molecule: it marginates neutrophils during acute inflammation

2

What two cells have abundant telomerase expression?

Cancer cells and germ cells. Somatic cells do not normally express telomerase

3

What gene is the catalytic subunit of telomerase?

Human telomerase reverse transcriptase

4

How do DNA viruses cause cancer?

They inactivate tumor suppressor genes

5

HPV PATHOGENESIS IS/?

E6 and E7 genes of HPV 16 bind p53 and pRb

6

Carcinoma in situ

Cancers that don't penetrate the basement b membrane

7

Koilocytosis

Presence of squamous cells with perinuclear halos and nuclear changes. Indicative of HPV infection

8

What ion is adhering dependent on?

Calcium

9

What is function of Lysol hydroxylase?

Post translational modification of collagen

10

What kind of tumors exhibit Anaplasia?

High. Grade- they lack differentiated features

11

Papillomatosis

Fond-like structures

12

Medullary

Soft cellular tumor

13

Scirrhous or desmoplastlc

Dense fibrous stroma

14

Colloidal carcinoma

Secretes abundant mucus

15

What compound is normally seen produced inlung cancers?

Corticotropin (ACTH)

16

What would happen to adrenal function in adrenal and pituitary metastases? What disease is this?

Adrenal Function would be lost- Addison' s disease

17

Alpha fetal protein is a tumor marker for what carcinomas?

Yolk Sac and Hepatocellular

18

Calretinin is a tumor marker for what cancer?

Mesothelioma

19

Synaptophysin is a marker for what tumour?

Neuroendocrine- including small cell carcinoma of theking

20

Carcinoembryonic antigen is a marker for what cancer?

COLON and many others

21

How do RAD51 and BRA proteins 1&2 work together?

brca binds RAD to meditate double strand repair breaks

22

Chondroma

Benign cartaliginous tumor

23

Hamartoma

Disorganized normal tissue

24

What are three features ofAtaxia Telangiectasia

1. Cellular degeneration
2. Immunological abnOrmalities
3. Predisposition to cancer

25

What cancer are albinism patients at risk for?

Squamous cell carcinoma of skin.

They do not have a defect in DNA excision repair

26

Describe anemia of a paraneoplastic syndrome.

The anemia is Neolithic and normochromic. Fe deficiency anemia normally I seen when the cancer is bleeding into the GI tract.

27

What are some chromosome alterations seen in solid tumors?

1. Homogenous staining regions
2; abnormal banding regions on fhromoome
3, double minutes

28

What symptoms are seen in carcinoid syndrome and why?

Serotonin, histamine and bradykinin are released and cause flushing, bronchial wheezing, watery diarrhea and abdominal colic

29

Where are carcinoid normally found?

Submucosa of the intestine

30

alpha-fetotprotein is a tumor marker for what cancers?

Hepatocellular carcinomas
Testicular CArcinomas

31

what is a choristoma?

benign mass composed of tissues not from the site of origin

32

what pathway of is activated by APC?

WNT signaling