Neoplasia 3: Epithelial cells tumors

Question 1

2 main types of benign epithelial tumors

Answer 1

• papilloma
• Adenoma

Question 2

2 main types of Malignant epithelial tumors

Answer 2

• Squamous cell carcinoma
• Adenocarcinoma

Question 3

Define papilloma

Answer 3

benign surface epithelial tumor

Question 4

Macroscopic morphology of papilloma

Answer 4

finger like fonds

Question 5

Microscopic morhology of papilloma

Answer 5

branching fibrovascular core covered by proliferated epithelium

Question 6

Define inverted papilloma

Answer 6

rare endophytic papilloma that grows inwards & pushes basement membrane without invasion

Question 7

examples of inverted papilloma

Answer 7

• urinary bladder
• Nose

Question 8

Papilloma is divided into

Answer 8

• Squamous cell Papilloma
• Transitional cell (villous) papilloma
• Columnar cell (duct) papilloma

Question 9

define squamous cell papilloma

Answer 9

benign tumor of stratified squamous epithelium

Question 10

define transitional cell (villous) papilloma

Answer 10

benign (but strongly pre-malignant) of urothelium (of the urinary tract)

Question 11

gross morphology of squamous cell papilloma

Answer 11

• small sessile (neck) or pedunculated (no neck) projections, may cause branching folds & complex papillary if prgoresses in growth

Question 12

microscopic morphology of squamous cell papilloma

Answer 12

fibrovascular core covered by proliferating stratified squamous epithelium showing acanthosis (dark skin) & hyperkeratosis

Question 13

example of Columnar cell papilloma

Answer 13

duct papilloma in major ducts as pancreas & breast

Question 14

which type of papilloma is the most pre malignant

Answer 14

transitional cell (villous) papilloma

Question 15

Define Adenoma

Answer 15

benign tumor from glandular epithelium

Question 16

gross morphology of exocrine/ endocrine Adenomas

Answer 16

capsulated globular or ovoid mass

Question 17

Microscopic morphology of exocrine/endocrine adenomas is divided into:

Answer 17

• Simple (tubular) adenoma
• Fibroadenoma
• Cystadenoma
• papillary cystadenoma

Question 18

example of simple (tubular) adenoma

Answer 18

Pancreatic adenoma

Question 19

example of fibroadenoma

Answer 19

breast cancer

Question 20

example of Cystadenoma

Answer 20

Ovarian cystadenoma

Question 21

example of papillary cystadenoma

Answer 21

(like normal cystadenoma) ovary

Question 22

complications of endocrine/exocrine adenomas

Answer 22

• adenoma may function and release hormones (ex: thyrotoxicosis)
• Malignant change to adenocarcinoma

Question 23

Microscopic Morphology of Mucosal Adenomas

Answer 23

• cores of proliferated glands
• covered by columnar epithelium

Question 24

General features of carcinomas arising from surface

Answer 24

• Fungating polypoid mass
• Ulcerative pattern: raised everted edges & rough necrotic floor
• Infiltrative pattern
• (in hollow organs) annular

Question 25

2 main types of carcionma

Answer 25

* Squamous cell carcinoma * Adenocarcinoma

Question 26

predisposing factors linked to Squamous cell carcinoma

Answer 26

* Sun exposure * Arsenic * ionizing radiation * urinary bladder during **bilharziasis** (squamous metaplasia)

Question 27

sites of squamous cell carcinoma

Answer 27

* Skin * Squamous mucous membranes * sqamous metaplasia

Question 28

Microscopic morphology of Squamous cell carcinoma

Answer 28

penetration of basement membranes by nests: 1. peripheral basal cells 2. granular cells 3. Squamous cells 4. Keratin pearls (dyskeratosis)

Question 29

Border's grading depends on what charactaristic in SCC

Answer 29

the degree of Dyskeratosis= Nest (keratin) formation

Question 30

Microscopic morphology of Adenocarcinomas is divided into

Answer 30

* well defined adenocarcinoma * Mucin secreting Carcinoma * Carcinoma simplex

Question 31

describe well defined adenocarcinoma

Answer 31

* Irregular **acinar** arrangement with no basement membrane * irregular lumen * found in abdnormal sites/layer (submucosa, musculosa) due to inflitration of basement membrane * cells show malignant anaplastic features * may be cystic dilated = Cystadenocarcinoma * May show papillaried = papillary adenocarcinoma * May shwo cysts & papillaries = Papillary cystadenocarcinoma

Question 32

Site of mucin secreting carcinomas

Answer 32

Stomach & Colon

Question 33

Adenocarcinoma with abundant extracytoplasmic mucin secretion is called ___

Answer 33

Mucinous/mucoid/Colloid Adenocarcinoma

Question 34

Adenocarcinoma with abundant intracytoplasmic mucin secretion is called ___

Answer 34

Signet ring cell adenocarcinoma

Question 35

Carcinoma simplex is also known as ____

Answer 35

spheroid cell carcinoma

Question 36

Define carcinoma simplex

Answer 36

malingnat tumor of glandular origin that doesnt exhibit neither acinar differentiation nor secrete Mucin

Question 37

Most common site of carcinoma simplex

Answer 37

Breast