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INT 208: Pathology > Neoplasia 3: Epithelial cells tumors > Flashcards

Neoplasia 3: Epithelial cells tumors Flashcards

1
Q

2 main types of benign epithelial tumors

A
  • papilloma
  • Adenoma
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2
Q

2 main types of Malignant epithelial tumors

A
  • Squamous cell carcinoma
  • Adenocarcinoma
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3
Q

Define papilloma

A

benign surface epithelial tumor

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4
Q

Macroscopic morphology of papilloma

A

finger like fonds

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5
Q

Microscopic morhology of papilloma

A

branching fibrovascular core covered by proliferated epithelium

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6
Q

Define inverted papilloma

A

rare endophytic papilloma that grows inwards & pushes basement membrane without invasion

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7
Q

examples of inverted papilloma

A
  • urinary bladder
  • Nose
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8
Q

Papilloma is divided into

A
  • Squamous cell Papilloma
  • Transitional cell (villous) papilloma
  • Columnar cell (duct) papilloma
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9
Q

define squamous cell papilloma

A

benign tumor of stratified squamous epithelium

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10
Q

define transitional cell (villous) papilloma

A

benign (but strongly pre-malignant) of urothelium (of the urinary tract)

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11
Q

gross morphology of squamous cell papilloma

A
  • small sessile (neck) or pedunculated (no neck) projections, may cause branching folds & complex papillary if prgoresses in growth
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12
Q

microscopic morphology of squamous cell papilloma

A

fibrovascular core covered by proliferating stratified squamous epithelium showing acanthosis (dark skin) & hyperkeratosis

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13
Q

example of Columnar cell papilloma

A

duct papilloma in major ducts as pancreas & breast

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14
Q

which type of papilloma is the most pre malignant

A

transitional cell (villous) papilloma

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15
Q

Define Adenoma

A

benign tumor from glandular epithelium

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16
Q

gross morphology of exocrine/ endocrine Adenomas

A

capsulated globular or ovoid mass

17
Q

Microscopic morphology of exocrine/endocrine adenomas is divided into:

A
  • Simple (tubular) adenoma
  • Fibroadenoma
  • Cystadenoma
  • papillary cystadenoma
18
Q

example of simple (tubular) adenoma

A

Pancreatic adenoma

19
Q

example of fibroadenoma

A

breast cancer

20
Q

example of Cystadenoma

A

Ovarian cystadenoma

21
Q

example of papillary cystadenoma

A

(like normal cystadenoma) ovary

22
Q

complications of endocrine/exocrine adenomas

A
  • adenoma may function and release hormones (ex: thyrotoxicosis)
  • Malignant change to adenocarcinoma
23
Q

Microscopic Morphology of Mucosal Adenomas

A
  • cores of proliferated glands
  • covered by columnar epithelium
24
Q

General features of carcinomas arising from surface

A
  • Fungating polypoid mass
  • Ulcerative pattern: raised everted edges & rough necrotic floor
  • Infiltrative pattern
  • (in hollow organs) annular
25
Q

2 main types of carcionma

A
  • Squamous cell carcinoma
  • Adenocarcinoma
26
Q

predisposing factors linked to Squamous cell carcinoma

A
  • Sun exposure
  • Arsenic
  • ionizing radiation
  • urinary bladder during bilharziasis (squamous metaplasia)
27
Q

sites of squamous cell carcinoma

A
  • Skin
  • Squamous mucous membranes
  • sqamous metaplasia
28
Q

Microscopic morphology of Squamous cell carcinoma

A

penetration of basement membranes by nests:
1. peripheral basal cells
2. granular cells
3. Squamous cells
4. Keratin pearls (dyskeratosis)

29
Q

Border’s grading depends on what charactaristic in SCC

A

the degree of Dyskeratosis= Nest (keratin) formation

30
Q

Microscopic morphology of Adenocarcinomas is divided into

A
  • well defined adenocarcinoma
  • Mucin secreting Carcinoma
  • Carcinoma simplex
31
Q

describe well defined adenocarcinoma

A
  • Irregular acinar arrangement with no basement membrane
  • irregular lumen
  • found in abdnormal sites/layer (submucosa, musculosa) due to inflitration of basement membrane
  • cells show malignant anaplastic features
  • may be cystic dilated = Cystadenocarcinoma
  • May show papillaried = papillary adenocarcinoma
  • May shwo cysts & papillaries = Papillary cystadenocarcinoma
32
Q

Site of mucin secreting carcinomas

A

Stomach & Colon

33
Q

Adenocarcinoma with abundant extracytoplasmic mucin secretion is called ___

A

Mucinous/mucoid/Colloid Adenocarcinoma

34
Q

Adenocarcinoma with abundant intracytoplasmic mucin secretion is called ___

A

Signet ring cell adenocarcinoma

35
Q

Carcinoma simplex is also known as ____

A

spheroid cell carcinoma

36
Q

Define carcinoma simplex

A

malingnat tumor of glandular origin that doesnt exhibit neither acinar differentiation nor secrete Mucin

37
Q

Most common site of carcinoma simplex

A

Breast

INT 208: Pathology (27 decks)

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