Neoplasia

Question 1

Which of the following chemcials will lead to Hepatocellular carcinoma

derived from aspergillus, which can contaminate stored grains

Answer 1

alfatoxins

Question 2

which of the following chemicasl is assoc with leujemia/lymphoma (side effect of chemotherapy)

Answer 2

alkylating agents

Question 3

Name the chemical associated with the following cancers:

squamous cell carcinoma of oropharnyx & upper esophagus, pancreatic carcinoma and hepatocellular carcinoma

Answer 3

Alcohol

Question 4

Name the chemical associated with the following cancers:

squamous cell carcinoma of skin, lung cancer, and angiosarcoma of the liver

_____ is also present in cigarette smoke

Answer 4

Arsenic

Question 5

Name the chemical associated with the following cancers:

carcinoma of oropharnyxm, esophagus, lung, kidney, bladder

MCC carcinogen worldwide; polycyclic hydrocarbons are particularly carcinogenic.

Answer 5

Cigarette smoke

Question 6

Name the chemical associated with the following ca

Stomach carcinoma

found in smoked foods, responsible for high rate of stomach carcinoma in JAPAN!

Answer 6

Nitrosamines

Question 7

Name the chemical assoc with teh following CA: Urothelial carcinoma of bladder

Derived from cigarette smoke

Answer 7

Naplithy lamine

Question 8

Name the chemical associated with the following cancer:

Angiosarcoma of the lung

occupational exposure, used to make PVC polyvinyl chlurkle for use in pipes

Answer 8

Vinyl chloride

Question 9

Which of the following chemcials are associated with lung carcinoma (occupational exposure)

NBCS

Answer 9

Nickel

Chromium

Beryllium

Silica

Question 10

Which oncogenic viruses are assoc with the following cancers:

Nasopharyngeal carcinoma (asian pop), burkitt lymphoma, CNS lymphoma in AIDS

Answer 10

EBV

Question 11

Which oncogenic viruses are assoc with the following cancers:

Kaposi sarcoma

• Tumor of endothelial cells (older European males (excision))
• AIDS pts (treate virusts anti-retroviral agents)
• Pts w/transplant (dec immunosuppresion)

Answer 11

HHV-8

Question 12

Which oncogenic viruses are assoc with the following cancers:

Hepatocellular carcinoma

Answer 12

HBV (DNA)

HCV (RNA)

Question 13

Which oncogenic viruses are assoc with the following cancers:

Adult T-cell leukemia/lymphoma

Answer 13

HTLV-1

Question 14

Which oncogenic viruses are assoc with the following cancers:

Squamous cell carcinoma (vulva, vagina, anus and cervix)

adenocarcinoma of cervix

Answer 14

HPV (High risk) 16,18,31,33

Question 15

Which radiation are assoc with the following cancers:

AML, CML, papillary carcinoma of the thyroid

(generates free radicals)

give 2 exampels

Answer 15

• Ionizing
  
  • nuclear reactor accidents
  • radiothearpy

Question 16

Which radiation are assoc with the following cancers:

Basal cell carcinoma, squamous cell carcinoma, melanoma of skin

results in formation of pyrimidine dimers in DNa (which are normally excised by restirciton endonuclease) xeroderma pigmantosum

give an example:

Answer 16

• non-ionizing
  
  • MC: UVB