Neoplasia- oncogenes

Question 1

Name the growth factors describe in lecture

Answer 1

PDGFB

(platelet drived growth factor beta)

Question 2

Name the associated growth factor with the following tumor(s)

Astroctyoma (Glial cell)

define: func and mechanism

Answer 2

• PDGF-B
  
  • fun: Platelet derived growth factor beta
  • mech: Overexpression, autocrine loop

Question 3

Name the 3 growth factor receptors discussed

Answer 3

• HER2/neu (ERBB2)
• RET
• KIT

Question 4

Name the associated growth factor receptor with the following tumor(s)

subset of breast carcinomas

define: func and mechanism

Answer 4

• HER2/neu (ERRB2)
  
  • fun: epidermal growth factor receptor
  • mech: amplification

Question 5

Name the associated growth factor receptor with the following tumor(s)

MEN2a, MEN2b, sporadice medullary carcinoma of the thyroid

define: func and mechanism

Answer 5

• RET
  
  • Neural growth factor
  • point mutation

Question 6

Name the associated growth factor receptor with the following tumor(s)

Gastrointestinal stromal tumor

define: func and mechanism

Answer 6

• KIT
  
  • fun: stem cell growth factor receptor
  • mech: Point mutation

Question 7

Name the associated singal transduction with the following tumor(s)

Gacrinomas, melanoma, lymphoma

define: func and mechanism

Answer 7

• RAS gene family
  
  • fun: GTP-binding proteins
  • mech: point mutation

Question 8

Name the 2 signal transducers

Answer 8

• RAS gene family
• ABL

Question 9

Name the associated signal transducers with the following tumor(s)

CML and some types of ALL (adult ALL philidelphia ALL)

define: func and mechanism

Answer 9

• ABL
  
  • fun: Tyrosine kinase
  • mech: t (9:22)
    
    • w/BCR defines CML

Question 10

Name the 3 nuclear regulators

Answer 10

• c-MYC
• N-MYC
• L-MYC

Question 11

Name the associated nuclear regulator with the following tumor(s)

burkitt lymphoma

define: func and mechanism

Answer 11

• c-MYC
  
  • fun: transcription factor
  • mech: t(8:14) involving IgH

Question 12

Name the associated nuclear regulator with the following tumor(s)

Neuroblastoma

define: func and mechanism

Answer 12

• N-Myc
  
  • func: transcription factor
  • mech: Amplification

Question 13

Name the associated nuclear regulator with the following tumor(s)

Lung carcinoma (small cell)

define: func and mechanism

Answer 13

• L-Myc
  
  • func: transcrition factor
  • Amplification

Question 14

name the 2 cell cycle regulators

Answer 14

• CCND1 (cyclin D1)
• CDK4

Question 15

Name the associated nuclear regulator with the following tumor(s)

Mantle cell lymphoma

define: func and mechanism

Answer 15

• CCND1 (cell cyclin D1)
  
  • func: cyclin
  • mech: t (11,14)

Question 16

Name the associated nuclear regulator with the following tumor(s)

Melanoma

define: func and mechanism

Answer 16

• CDK4
  
  • fun: cyclin-dependant kinase
  • mech: amplification