Neoplasia I #5 (1/25/16) Flashcards Preview

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Flashcards in Neoplasia I #5 (1/25/16) Deck (26):
1

What is Neoplasia?

"New Growth" = loss of responsiveness to normal growth controls.
*Sometimes benign, sometimes Malignant (Cancer)

2

What is a parenchyma?
What is a stroma?

Parenchyma = Neoplastic cells
Stroma = Supporting CT and blood vessels

3

What is a Hamartoma?

Proliferation of tissue normally found at site.

4

What is an Choristoma?

Collection of tissue not normally found in that anatomic site.

5

What is a Teratoma?

Neoplasm derived from more than one germ layer, behavior ranges from begin to aggressive.

6

What are Malignancies?

Similar to benign nomenclature, with certain exceptions.
- Mesenchymal malignancies are termed "sarcoma"
- Epithelial malignancies are termed carcinoma (Squamous ell carcinoma or adenocarcinoma

7

What is a lymphoma?

Malignancy of lymphoid tissue

8

What is Melanoma?

Malignancy of Melanocytes

9

What is Seminoma?

Testicular Malignancy

10

What is Mesothelioma?

Pleural Malignancy

11

How do you discern between benign and malignant?

- Differentiation
- Rate of growth
- Local Invasion
- Metastasis

12

Tell me about Differentiation...

Differentiation refers to how well the parenchymal cells of the neoplasm resemble their normal tissue of origin.

*Benign tumors almost always closely resemble normal tissue microscopically.
*Mitoses are usually scarce and normal in appearance.

13

T or F, Malignant tumors may have a wide range of Differentiation.

True

14

Poorly differentiated malignancies are termed ______.

Anaplastic (High grade)

15

T or F, Well differentiated malignancies resemble normal tissue to a large extent.

True

16

_____ is the most extreme disturbance in cell growth and differentiation.

Anaplasia
Features:
- Pleomorphism
- Nuclear hyperchromatism and vacation in nuclear size and shape.
- numerous and atypical mitoses

17

What is Dysplasia?

Disorderly, but non-neoplastic growth or proliferation.
- Usually refers to epithelial process of maturation.
- Cellular Atypia and architectural changes ranging from mild to carcinoma-in-stu.
- Potential to become invasive carcinoma

18

T or F, Malignacies are often well differentiated and more likely to retain function compared to Benign tumors.

False, Benign tumors are more likely to be well differentiated and retain function.

19

T or F, Malignancies may produce proteins that are function but unrelated to the tissue type of the tumor.

true

20

Benign tumors usually grow ______.

Slowly

21

Well differentiated malignancies usually grow ____ while poorly differentiated malignancies tend to grow _____.

Slowly
Rapidly

22

What happens if a tumor outgrows its blood supply?

Areas of Ischemic necrosis occur.

23

What is Local Invasion?

Benign Neoplasms tend to remain localized-slow growth usually results in formation of a compressed layer of connective tissue enclosing the tumor.
*Most, but not all benign tumors have a fibrous capsule.

24

Do malignancies have well defined capsules?

Nope

25

How do malignancies grow?

by invasion, infiltration and destruction of surrounding tissue.

26

_____ is the most reliable feature for distinguishing malignant from benign tumors.

Local invasiveness