Neoplasia II

Question 1

How do you give a histological description of a neoplasm?

Answer 1

• Location
• Capsulated or Unencapsulated
• well demarcated or poorly demarcated
• Expansile, infiltrative, or compressing adjacent tissue
• Shape (nodular, multilobular, verrucous, etc.)

Question 2

What is the characteristic pattern of carcinomas

Answer 2

nests, packets, lobules

Question 3

What is the characteristic pattern of adenocarcinomas?

Answer 3

tubules, acini

Question 4

What is the characteristic pattern of sarcomas?

Answer 4

bundles, streams

Question 5

What is the characteristic pattern of round cell tumours?

Answer 5

Sheets, Cords

Question 6

What is the characteristic pattern of endocrine tumours?

Answer 6

Packets

Question 7

What three things do you note about the cytological features of a neoplasm?

Answer 7

• Shape
• Cell Borders
• Cytoplasm (Amount, Colour, Character)

Question 8

What are some morphological features of malignancy?

Answer 8

• Loss of tissue organisation
• Invasion
• No capsule or invasion of capsule
• Vascular invasion
• Metastasis
• Necrosis
• Haemorrhage

Question 9

What is neoplastic transformation?

Answer 9

Uncontrolled proliferation

Question 10

What occurs with DNA damage in neoplastic cells?

Answer 10

• They have either lost or there is mutation with the p53 gene
• The cell cycle arrests and repair is not induced
• The genetically damaged cells proliferate and accumulate mutations (otherwise known as a tumour)

Question 11

What is angiogenesis?

Answer 11

Continued growth of solid tumours which depends
* on an adequate blood supply
* nutrients and oxygen
* they are disorganised, unstable and leaky