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neoplasm - conditions Flashcards

1
Q

ulcerative colitis - neoplasm

A

colon adenocarcinoma

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2
Q

chronic atrophic gastritis - neoplasm

A

it predisposes to gastric adenocarcinoma

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3
Q

postsurgical gastric remnants - neoplasms

A

it predisposes to gastric adenocarcinoma

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4
Q

aids predispose to (neoplasm)

A
  1. aggressive lymphoma (non-Hodgkin)

2. Kaposi sarcoma

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5
Q

Down syndrome - neoplasm

A

ALL, AML

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6
Q

immunodeficiency predisposes to (neoplasm)

A
  1. lymphoma
  2. melanoma
  3. renal cell carcinoma
  4. SCC of skin
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7
Q

Li-Fraumeni syndrome predisposes to (neoplasm)

A

various cancers at young age (eg. sarcoma, breast, leukemia, adrenal gland)

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8
Q

radiation exposure - high risk of developing (neoplasm)

A

leukemia, sarcoma, papillaty thyroid cacner, breast cancer

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9
Q

actinic keratosis - precursor to (neoplasm)

A

squamous cell carcinoma of the skin

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10
Q

paget disease of bone predisposes to (neoplasm)

A
  1. osteosarcoma

2. fibrosarcoma

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11
Q

dematomyositis predisposes to (neoplasm)

A

visceral malignancy (particularly genitourinary)

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12
Q

polymyositis predisposes to (neoplasm)

A

visceral malignancy (particularly genitourinary)

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13
Q

dermatomyositis and polymyositis predispose to visceral malignancy particularly

A

genitourinary

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14
Q

Xeroderma pigmentosum predisposes to

A

skin cancer (BCC, SCC, melanoma)

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15
Q

Oncogenes role in cancer

A

gain of function –> increase cancer risk

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16
Q

oncogenes and cancer - need damage … allele (number)

A

only 1

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17
Q

tumor suppressor genes role in cancer

A

loss of function –> increase cancer risk

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18
Q

tumor suppressor genes and cancer - need damage … allele (number)

A

both allele

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19
Q

BCR-ABL - oncogene or tumor suppressor gene?

A

oncogene

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20
Q

RET - oncogene or tumor suppressor gene?

A

oncogene

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21
Q

RAS - oncogene or tumor suppressor gene?

A

oncogene

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22
Q

APC - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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23
Q

Rb - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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24
Q

NF1 - oncogene or tumor suppressor gene?

A

tumor suppressor gene

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25
NF2 - oncogene or tumor suppressor gene?
tumor suppressor gene
26
c-myc - oncogene or tumor suppressor gene?
oncogene
27
c-kit - oncogene or tumor suppressor gene?
oncogene
28
BRAF - oncogene or tumor suppressor gene?
oncogene
29
DCC - oncogene or tumor suppressor gene?
tumor suppressor gene
30
MEN1 - oncogene or tumor suppressor gene?
tumor suppressor gene
31
DPC4/SMAD4 - oncogene or tumor suppressor gene?
tumor suppressor gene
32
BRCA1/BRCA2 - oncogene or tumor suppressor gene?
tumor suppressor gene
33
WT1/WT2 - oncogene or tumor suppressor gene?
tumor suppressor gene
34
VHL - oncogene or tumor suppressor gene?
tumor suppressor gene
35
L-myc - oncogene or tumor suppressor gene?
oncogene
36
N-myc - oncogene or tumor suppressor gene?
oncogene
37
p16 - oncogene or tumor suppressor gene?
tumor suppressor gene
38
p53 - oncogene or tumor suppressor gene?
tumor suppressor gene
39
PTEN - oncogene or tumor suppressor gene?
tumor suppressor gene
40
BCL2 - oncogene or tumor suppressor gene?
oncogene
41
TSC1 - oncogene or tumor suppressor gene?
tumor suppressor gene
42
TSC2 - oncogene or tumor suppressor gene?
tumor suppressor gene
43
HER2/neu (c-erbB2) - oncogene or tumor suppressor gene?
oncogene
44
BCR-ABL - product
Tyrosine kinase
45
BCR-ABL - associated tumor
CML/AML
46
BRAF - product
serine/threonine kinase
47
BRAF - associated tumor
Melanoma, non-Hodgkin lymphoma
48
BCL-2 - associated tumor
follicular and undifferentiated lymphomas
49
BCL-2 - product
antiapoptotic molecule (inhibits apoptosis)
50
RET - product
tyrosine kinase
51
RET - associated tumor
MEN2A and MEN2B, medullary thyroid cancer, thyroid papillary carcinoma
52
RAS - product
GTPase
53
RAS - associated tumor
colon cancer, lung cancer, pancreatic cancer
54
c-kit - product
cytokine receptor
55
c-kit - associated tumor
gastrointestinal stromal tumor (GIST)
56
c-myc - products
Transcription factor
57
c-myc - associated tumor
Burkitt lymphoma
58
L-myc - gene product
Transcription factor
59
L-myc - associated tumor
Lung tumor
60
N-myc - gene product
Transcription factor
61
N-myc - associated tumor
neuroblastoma
62
HER2/neu (c-erbB2) - product
Tyrosine kinase
63
HER2/neu (c-erbB2) - associated tumor
Breast, gastric carcinomas
64
APC - associated tumor
Colorectal cancer (associated with FAP)
65
BRCA1/2 - associated tumor
breast and ovarian cancer
66
BRCA1/2 - product
gene repair protein
67
DCC - associated tumor
colon cancer
68
DPC4/SMAD4 - associated tumor
pancreatic cancer
69
MEN1 - product
menin
70
MEN1 - associated tumor
MEN1
71
WT1/WT2 - associated tumor
Wilms tumor (neuroblastoma)
72
VHL product
HIF1a inhibitor
73
VHL - associated tumor
VHL disease | renal cell carcinoma
74
TSC1 - product
Hamartin protein
75
TSC1 - associated tumor
tuberous sclerosis
76
TSC2 - product
Tuberin protein
77
TSC2 - associated tumor
tuberous sclerosis
78
Rb - product
inhibits E2F --> blocks G1 to S phase
79
PTEN - associated tumor
1. breast 2. prostate 3. endometrial
80
Rb - associated tumor
1. Retinoblastoma | 2. osteosracoma
81
NF1 - associated tumor
Neurofibromatosis type 1
82
NF2 - associated tumor
Neurofibromatosis type 2
83
NF2 - product
Merlin (schwannomin protein)
84
NF1 - product
Ras GTPase activating protein (neurofibromin)
85
p16 - product
Cyclin-dependent kinase inhibitor 2A
86
p16 - associated tumor
melanoma
87
p53 - product
Transcription factor for p21--> blocks G1 to S phase
88
p53 - associated tumor
1. Most human cancers | 2. Li-Fraumeni syndrome

Pathology FA (4 decks)

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