NEURO 3 Flashcards
(27 cards)
triad of motor features in parkinson’s
bradykinesia, rigidity and tremor
non motor features in parkinson’s
olfactory dysf - loss of smell, cogni imp, psych, autonomic dysf, pain and fatigue, RBD
what is rapid eye movement sleep disorder
abn behaious during rapid eye movement sleep - related to dream enactment
RBD and PDx
together - severe autonomic dysf, gait impairment and dementia
just RBD - increased risk of developing neurodegenerative condition
resting tremor
3-5Hz
frements
rigidity by voluntary movement of other body parts
what can happen if medications are not absorbed properly in parsons
increased risk of acute akinesia/neuroepileptic malignant syndrome - take a drug holiday
dopamine agonists examples and which drugs need investigations before they can be initiated and why
ropinerole, pramiperole, apomorphine
bromocriptine, cabergoline - ECHO, ESR, CXR
pulmonary , retroperitoneal and cardiac fibrosis
why shouldnt DA be prescribed in elderly and confused px
SE include hallucinations
what is given along with levodopa and why
cabidopa/berverazide to prevent peripheral metabolism of levodopa into dopamine
reddish colour on standing
levodopa
what can happen at peak concentrations of leveopa
beginning and end of dose - chloroform/dystonic movements - biphasic dyskinesia
fluctuations
add DA/MAOBI (sergelline), COMTI (enalapore/tolapore)
psychosis
clozapine
quetiapine
depression
antidep
visual hallucinations/delusions in dementia
late stage dementia
rivastigamine
other options for side effects of levodopa
direct delivery of stable levodopa
carbiopa gel
duodepal - in dueodenum
other optiosn for side effects of DA
subcut infusion of potent DA - apomorphine
excessive sleepiness
don’t drive
adjust meds
modafenil
constipation
GI motility
fatigue
hypotentsion
polythyleneglyco/lubiprostone
domperidone
methypheindate
meds review. midodrine, clomperidone, fludrostinoma, pyridogmistigive
parkinsonism - 6
vascular drug induced multisystem progressive supranuclear fragile X tremore ataxia syndrome essential tremor
vascular
lower body predom
drug induced
symmetry coarse postural tremor
multisystem
autonomic dysf
cerebellar symp
parkinsonism
hot cross bun sign
