Neuro - Guillain Barre Flashcards
what is guillain-barre syndrome?
acute paralytic polyneuropathy
affects PNS
PNS or CNS affected?
PNS
classical symptoms
acute, symmetrical ascending weakness
sensory symptoms
trigger
infection - campylobacter jejuni, cytomegalovirus and EBV
underlying pathophysiology
molecular mimicry
explain molecular mimicry
B cells create antibodies
target proteins on myelin sheath of nerve axon
reflexes
reduced
sensation and pain
peripheral loss
clinical course
within 4 weeks of infection
start in feet and move up
peak 2-4 weeks then recovery
diagnostic criteria
brighton criteria
diagnosis
brighton criteria
nerve conduction
lumbar puncture
lumbar puncture findings
raised protein
management
IVIg
plasma exchange
VTE prophylaxis
ICU
prognosis
80% fully recover
5% fatal
main causes of mortality
PE
respiratory insufficiency
cardiac arrest
