Neurobio Class 1-2 Flashcards Preview

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Flashcards in Neurobio Class 1-2 Deck (33):
1

An equation which can be used to find the equilibrium potential for a particular ion

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2

ln(y) =

2.3log(y)

3

Calculate the equilibrium potential of potassium if the intracellular conc. is 150 and the extracellular 10 at physiological temperature.

E = (61/z)log([K+]out/[K+]in)

4

Physiological temp.

37 degrees C

5

Room temp

20 degrees C

6

Calculate the equilibrium potential of an ion at given extracellular and intraceullar concentrations at room temp

E = (58/z)mV x log([Ion]out/[Ion]in)

7

How can so many ions flow in and out when action potentials are so rapid?

Conc. changes are a few micromoles

8

What is the purpose of an action potential?

To control intracellular [Ca2+]

9

Conc. of Ca2+ inside cell

0.1 mM

(not a ton, 0.1)

10

Conc. of Ca2+ outside cell

1.8 mM

(1.8 outside the gate)

11

Ions whose extracellular concentrations exceed 100 mM

Na+ and Cl-

Why I love table salt?

12

Ions whose extracellular conc. are less than 2 mM

Mg2+, Ca2+, H+

So basically remember Magnesium is 1.5 mM

13

Mg2+, Ca2+, H+

Ions whose extracellular conc. are less than 2 mM

14

 pH inside the cell

7.2-7.4 (same as outside)

15

Extracellular K+ conc

4 mM, same as intracellular Cl-

16

Extracellular HCO3- conc.

29 mM (about 3x intra, which is 12 mM)

17

Magnesium conc. inside cell

1.5 mM, same as outside

18

Ions whose intracellular conc. exceed 100

K+ and negatively charged nucleotides/other organic molecules

(139, 138)

19

What is the RMP of a typical neuron

between -50 and -90 mV

20

How can you tell axons from dendrites when they are entangled

Tagged antibodies for specific microtubule binding proteins. MAP2 shared by soma and dendrites. Tau found mainly in axons.

21

How can a scientist dintinguish axons from dendrites?

Tagged antibodies for specific microtubule-binding proteins: MAPII soma and dendrites, Tau mainly axons

22

Parts of neuron

1. dendrites

2. cell body (soma)

3. axon

4. axon terminals

23

Example of an early 20th century honor bestowed for something related to neuroscience

1906 Nobel for Physiology or Medicine

Camilo Golgi and Santiago Roman y Cajol for work on structure of nervous system.

24

Functional classifications of neurons

SIM

1. sensory

2. interneurons (relay/projectile and local)

3. motor

25

Morphological Classifications of neurons

BUM

1. Bipolar

2. Unipolar & pseudo-unipolar (DRG)

3. Multipolar

 

26

Tracing action potential along neuron

Input at soma, integration at axon hillock, conductoin through axon, output at terminals of axon

 

27

Excititory post synaptic potential looks like

A image thumb
28

Inhibitory post synaptic potential looks like

A image thumb
29

Schwann cells belong to

PNS

30

make myelin sheath for CNS

oligodendrocytes

31

types of glial cells

SOA

Schwan

oligodendrocytes

astrocytes

32

Functions of glial cells

Signal SSS + GFR

myelin sheath

structural support

scavenge debris

signalling: uptake neurotransmitters/buffer K+

guide neuron migration/axon outgrowth

form blood-brain barrier

release growth factors that nourish

 

33

The reason xtracellular K+ concentrations differs from that predicted by Nernst equation

Sodium leaves cell and membrane potential is less negative at low xtracellular K+ concentrations