Neurodegenerative Diseases

Question 1

Define neurodegenerative disease, describe common aetiology and state common outcome(209)

Answer 1

Question 2

Define dementia, describe its presentation. For five different diseases causing dementia, state the pathological protein involved(209)

Answer 2

Question 3

Discuss epidemiology, aetiology, clinical features, investigation and treatment of Alzheimer dsisease(209)

Answer 3

Question 4

Discuss aetiology of dementia with Lewy bodies(209)

Answer 4

Question 5

Describe the aetiology of idiopathic parkinson’s disease and describe their presenting features[NPR](include details of the different Parkinson Plus syndromes NPR

Answer 5

In parkinsons Lewy bodies accumulate in basal ganglia but in levy body dementia , Lewy bodies accumulate all over the cerebral cortex

Question 6

Desribe the presenting features of multipke sclerosis and describe its aetiology. Describe What to MS plaques showNPR

Answer 6

If needed:https://cks.nice.org.uk/topics/multiple-sclerosis/diagnosis/initial-presentation/

The symptoms of MS vary widely from person to person and can affect any part of the body.T

The main symptoms include(optic neuritis is a key presentation):

fatigue
difficulty walking
vision problems, such as blurred vision
problems controlling the bladder
numbness or tingling in different parts of the body
muscle stiffness and spasms
problems with balance and co-ordination
problems with thinking, learning and planning