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Assessment & Diagnosis Final > Neurodegenerative Disorders > Flashcards

Neurodegenerative Disorders Flashcards

1
Q

How long does Guillain-Barre take to recover from?

A

6 months-1 year

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2
Q

What is the most common bacterial trigger for Guillain Barre?

A

Campylobacter jejuni

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3
Q

What kind of weakness does Guillain-Barre cause?

A

Symmetric and ascending (feet up)

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4
Q

What kind of sensory loss happens in Gullain Barre?

A

Distal sensory loss

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5
Q

What happens to reflexes in Guillain Barre?

A

Hypoactive or absent

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6
Q

How is Guillain Barre diagnosed?

A

History and physical

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7
Q

Is weakness in Guillain Barre acute or progressive?

A

Progressive

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8
Q

What is BP goal in Gullain Barre?

A

Up to 200 systolic

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9
Q

A negative inspiratory force of less than what is concerning?

A

Less than -30

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10
Q

A forced vital capacity below what is concerning?

A

Below 20

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11
Q

Should a pt with bulbar weakness be put on BiPaP?

A

No

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12
Q

Which agent shouild be avoided during RSI in Gullain Barre?

A

Succinylcholine

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13
Q

After how long on a vent should a Guillain Barre pt be trached?

A

After 2 weeks

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14
Q

What kind of weakness does myasthenia gravis cuase?

A

Fluctuating and symmetric weakness

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15
Q

Does weakness get worse or better with activity in myasthenia gravis?

A

Worse

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16
Q

What is the first line medication class for myasthenia gravis?

A

Cholinesterase inhibitors

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17
Q

Besides cholinesterase inhibitors, what other class of meds are myasthenia gravis pts on?

A

Steroids

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18
Q

Does MS have symmetric or asymmetric weakness?

A

Asymmetric

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19
Q

What happens to reflexes in MS?

A

Hyperreflexive

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20
Q

What medication is used to manage acute flares of MS?

A

Steroids

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21
Q

What is the etiology of Gullain Barre?

A

Post infectious

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22
Q

What is the most common viral trigger for Guillain Barre?

A

Cytomegalovirus

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23
Q

Is weakness more proximal or distal in Guillain Barre?

A

Proximal

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24
Q

Do you have pain with Guillain Barre?

A

Yes

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25
Q

Do autonomic changes happen in Guillain Barre?

A

Yes

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26
Q

What will you see on CSF in Guillain Barre?

A

Elevated protein

27
Q

What would MRI show in Guillain Barre?

A

Nerve root enhancement

28
Q

What is a normal negative inspiratory force?

A

-100

29
Q

What is forced vital capacity?

A

Maximum amount of air a person can expel from the lungs

30
Q

What is a normal forced vital capacity?

A

40-70

31
Q

Are secretions a contraindication to BiPaP?

A

Yes

32
Q

Which paralytic should be used during RSI for Guillain Barre?

A

Rocuronium

33
Q

What is the decision to extubate a Guillain Barre pt based on?

A

Muscle strength and serial PFTs

34
Q

What two immunotherapies can be given for Guillain Barre?

A

IVIG and PLEX

35
Q

MG causes what to happen to the thymus?

A

Thymic hyperplasia

36
Q

Which disease causes “fatigueable weakness”?

A

Myasthenia gravis

37
Q

What type of weakness does myasthenia gravis cause?

A

Fluctuating, proximal

38
Q

What happens to reflexes in MG?

A

Normal

39
Q

Are there sensory changes in MG?

A

No

40
Q

What two antibodies do you test for in MG?

A

AChR and MuSK

41
Q

What is the tensilon test used to diagnose?

A

MG

42
Q

What happens if you give tensilon and the pt has MG?

A

Ocular sx will resolve

43
Q

What will happen in the ice test if the pt has MG?

A

Ptosis will resolve

44
Q

What happens if you overdose an MG pt on cholinesterase inhibitors?

A

Cholinergic crisis

45
Q

What kind of immunomodulating therapy will MG pts be on?

A

Corticosteroids

46
Q

What is used in the treatment of myasthenic crisis?

A

IVIG and PLEX

47
Q

Thymectomy can be done for treatment of which disease?

A

MG

48
Q

What is the number one trigger of myasthenic crisis?

A

Infection

49
Q

What is a cholinergic crisis caused by?

A

Overdose of MG drugs

50
Q

Which type of MG crisis causes excess secretions?

A

Cholinergic

51
Q

Which type of MG crisis causes respiratory weakness?

A

Myasthenic

52
Q

Is MS a problem with the CNS or PNS?

A

CNS

53
Q

Does MS cause symmetric or asymmetric weakness?

A

Could be asymmetric

54
Q

What happens to reflexes in MS?

A

Will be high

55
Q

Fatigue is worse with what in MS?

A

Heat and activity

56
Q

What kind of clinical course do pts with MS have?

A

Relapsing remitting

57
Q

What will you see on brain MRI in MS?

A

Nonenhancing white matter lesions

58
Q

What is acute transverse myelitis?

A

Spinal cord inflammation

59
Q

What will happen to reflexes below the lesion in acute transverse myelitis?

A

Hypoactive or absent

60
Q

Dymelinating optic neuritis is is dymelination of which cranial nerve?

A

CNII

61
Q

What is the first line treatment for MS flares?

A

Steroids

62
Q

What is the second line treatment for MS flares?

A

PLEX

63
Q

Does immunomodulatory therapy reduce current MS lesions?

A

No, just slows development of future ones

Assessment & Diagnosis Final (6 decks)

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