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Flashcards in Neurological Conditions Deck (14)
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1
Q

MS peak incidence is at what age?

A

30

2
Q

What cells mediate the inflammatory process?

A

B cell & CD4 T cells

3
Q

Why is the disease relapsing remitting?

A

Demyelination heals intermittently causing improvement of symptoms

4
Q

Describe MS

A

Inflammatory process in brain & spinal cord causing discrete plaques of demyelination

5
Q

What parts of the body does MS affect?

A

Brain

Spinal cord

6
Q

What nerves does MS affect? What nerves does it never affect?

A

Affects central nervous system

Never affects peripheral nerves

7
Q

What is protective against MS?

A

Early exposure to sunlight

Rare in the tropics

8
Q

What genetic factors are linked to MS?

A

HLA-DRB1*15

9
Q

What is the most common presenting complaint of MS?

A

Optic neuritis - pain on movement of eye/ deterioration in central vision

10
Q

Spinal cord lesions would cause what symptoms in MS?

A

Numbness or tingling in limbs

11
Q

What brainstem symptoms would be present in MS?

A

Ataxia

Diplopia

12
Q

Where does demyelination occur with MS?

A

Optic nerve
Periventricular white matter
Brainstem

13
Q

What are the differential diagnoses for MS?

A

SLE
Sarcoid
Vascular lesion
Cord compression

14
Q

An MRI would show what changes in MS?

A

Plaques in periventricular white matter & brainstem