Neuromuscular Jxn Disorder Flashcards Preview

Neurology > Neuromuscular Jxn Disorder > Flashcards

Flashcards in Neuromuscular Jxn Disorder Deck (19)
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1
Q

Myasthenia gravis - sx?

A

weakness/fatigue of skeletal muscles: FACE!
improves w/ rest
furrow brow to overcome ptosis (can’t hold eyelids open)
cannot hold head up
cannot walk/sit
cannot swallow
respiratory difficulties -Myasthenic crisis
DTR IS OK!

2
Q

“I’m fine in the morning but by afternoon I can’t open my eyelids”

A

Myasthenia gravies (skeletal muscles of the face is used the most compared to other skeletal muslces)

3
Q

Myasthenic crisis?

A

cannot breathe (sx of myasthenia gravis)

4
Q

Myasthenia gravis- associated disorders?

A

thmoma
thymus
thyroid (hyper)

5
Q

Myasthenia gravis - dx?

A

antiboides of ach (b/c ach is at the neuromuscular jxn to depolarize)
antibodies of anticholinesterase (edrophonium) (b/c cholin and esterase is reuptaked to make ach-by product of used ach after depolarization)
CT/MR to r/o thymom
thyroid fxn test - r/o hyperthyroidism

6
Q

Myastenia gravis -tx?

A

long acting anticholinesterase inhibitor meds - pyridostimine
thymectomy if thymoma

7
Q

Lamber Eaton Myasthenic- pathophysio?

A

antibodies against teh Ca channels at the motor end plate (step 1 of step 7)

8
Q

LEMS - cx?

A

paraneoplastic (small cell carcinoma of lung)

9
Q

LEMS - sx?

A

VERY SIMILAR to myasthenia gravis but they have absent DTR

10
Q

Botulism?

A

most potent spore to man kind
blocks Ach release (step 2)
affects cholinergic nerve terminals

11
Q

Botulism - bug?

A

clostridium botulinum

12
Q

Botulism - sx?

A
begins at cranial nerve and spreads to extremities
spreading weakness!
NORMAL MENTAL/SENSORY
diplopia
ptosis
13
Q

Botulism - types?

A
food born (common)
wound 
intestinal (infants)
14
Q

Botulism - food borne cx? incubation? sx?

A
d/t canned food
incubation 18-36hrs
diplopia
ptosis
pupillary reflexes are down 
N&V
15
Q

Botulism - wound sx? incubation? population?

A

NO GI Sx
incubation 10 days
IV heron users

16
Q

Botulism - intestinal population? cx?

A

infants

honey

17
Q

Botulism - tx?

A

hospitalization
+/- vent
enemas to purge gut
antitoxins (BEFORE LAB RESULTS ARE OUT - ASAP)
botulism immune serum blogulin for infants

18
Q

Botulism - cosmetics?

A

smooth wrinkle lines

tx: strabismus, blepharospasm, UMN

19
Q

Myasthensia gravis has normal ___ upon PE?

A

NORMAL DTR