Neuromuscular Jxn Disorder Flashcards Preview

Neurology > Neuromuscular Jxn Disorder > Flashcards

Flashcards in Neuromuscular Jxn Disorder Deck (19):
1

Myasthenia gravis - sx?

weakness/fatigue of skeletal muscles: FACE!
improves w/ rest
furrow brow to overcome ptosis (can't hold eyelids open)
cannot hold head up
cannot walk/sit
cannot swallow
respiratory difficulties -Myasthenic crisis
DTR IS OK!

2

"I'm fine in the morning but by afternoon I can't open my eyelids"

Myasthenia gravies (skeletal muscles of the face is used the most compared to other skeletal muslces)

3

Myasthenic crisis?

cannot breathe (sx of myasthenia gravis)

4

Myasthenia gravis- associated disorders?

thmoma
thymus
thyroid (hyper)

5

Myasthenia gravis - dx?

antiboides of ach (b/c ach is at the neuromuscular jxn to depolarize)
antibodies of anticholinesterase (edrophonium) (b/c cholin and esterase is reuptaked to make ach-by product of used ach after depolarization)
CT/MR to r/o thymom
thyroid fxn test - r/o hyperthyroidism

6

Myastenia gravis -tx?

long acting anticholinesterase inhibitor meds - pyridostimine
thymectomy if thymoma

7

Lamber Eaton Myasthenic- pathophysio?

antibodies against teh Ca channels at the motor end plate (step 1 of step 7)

8

LEMS - cx?

paraneoplastic (small cell carcinoma of lung)

9

LEMS - sx?

VERY SIMILAR to myasthenia gravis but they have absent DTR

10

Botulism?

most potent spore to man kind
blocks Ach release (step 2)
affects cholinergic nerve terminals

11

Botulism - bug?

clostridium botulinum

12

Botulism - sx?

begins at cranial nerve and spreads to extremities
spreading weakness!
NORMAL MENTAL/SENSORY
diplopia
ptosis

13

Botulism - types?

food born (common)
wound
intestinal (infants)

14

Botulism - food borne cx? incubation? sx?

d/t canned food
incubation 18-36hrs
diplopia
ptosis
pupillary reflexes are down
N&V

15

Botulism - wound sx? incubation? population?

NO GI Sx
incubation 10 days
IV heron users

16

Botulism - intestinal population? cx?

infants
honey

17

Botulism - tx?

hospitalization
+/- vent
enemas to purge gut
antitoxins (BEFORE LAB RESULTS ARE OUT - ASAP)
botulism immune serum blogulin for infants

18

Botulism - cosmetics?

smooth wrinkle lines
tx: strabismus, blepharospasm, UMN

19

Myasthensia gravis has normal ___ upon PE?

NORMAL DTR