Flashcards in Neuromuscular Jxn Disorder Deck (19):
Myasthenia gravis - sx?
weakness/fatigue of skeletal muscles: FACE!
improves w/ rest
furrow brow to overcome ptosis (can't hold eyelids open)
cannot hold head up
respiratory difficulties -Myasthenic crisis
DTR IS OK!
"I'm fine in the morning but by afternoon I can't open my eyelids"
Myasthenia gravies (skeletal muscles of the face is used the most compared to other skeletal muslces)
cannot breathe (sx of myasthenia gravis)
Myasthenia gravis- associated disorders?
Myasthenia gravis - dx?
antiboides of ach (b/c ach is at the neuromuscular jxn to depolarize)
antibodies of anticholinesterase (edrophonium) (b/c cholin and esterase is reuptaked to make ach-by product of used ach after depolarization)
CT/MR to r/o thymom
thyroid fxn test - r/o hyperthyroidism
Myastenia gravis -tx?
long acting anticholinesterase inhibitor meds - pyridostimine
thymectomy if thymoma
Lamber Eaton Myasthenic- pathophysio?
antibodies against teh Ca channels at the motor end plate (step 1 of step 7)
LEMS - cx?
paraneoplastic (small cell carcinoma of lung)
LEMS - sx?
VERY SIMILAR to myasthenia gravis but they have absent DTR
most potent spore to man kind
blocks Ach release (step 2)
affects cholinergic nerve terminals
Botulism - bug?
Botulism - sx?
begins at cranial nerve and spreads to extremities
Botulism - types?
food born (common)
Botulism - food borne cx? incubation? sx?
d/t canned food
pupillary reflexes are down
Botulism - wound sx? incubation? population?
NO GI Sx
incubation 10 days
IV heron users
Botulism - intestinal population? cx?
Botulism - tx?
enemas to purge gut
antitoxins (BEFORE LAB RESULTS ARE OUT - ASAP)
botulism immune serum blogulin for infants
Botulism - cosmetics?
smooth wrinkle lines
tx: strabismus, blepharospasm, UMN