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Pass Program > Neuromuscular Physiology Pharmacology > Flashcards

Neuromuscular Physiology Pharmacology Flashcards

1
Q

What poison blocks the release of glycine from the spinal chord? What toxin?

A

Strychnine

Tetanus toxin

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2
Q

What drug used in Alzheimer’s blocks the glutamate effect on the NMDA pathway?

A

Memantine

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3
Q

What is the drug of choice for Alzheimer’s? (Acetyl coa esterase inhibitor)

A

Donepezil

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4
Q

Serotonin blocker that helps in patients with GI vomiting?

A

Ondansetron

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5
Q

DOC for treating neurologic symptoms of serotonin syndrome? Peripheral symptoms?

A

Ciproheptadine

Octreotide

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6
Q

What drug blocks substance P and increases a persons threshold for pain?

A

Capzacin

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7
Q

What drug takes the place of Choline and give you sympathetic side effects

A

Hemicholinium

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8
Q

What anticholinergic drug can be used in patients with diatonia (sustained muscle contraction)?

A

Benztropine

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9
Q

What is the DOC for motion sickness?

A

Scopolamine

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10
Q

What are the only 2 anticholinergics allowed for obstructive lung disease because they block c-GMP?

A

Ipartropium

Tiatropium

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11
Q

What drug is used for urge incontinence in adults?

A

Oxybutynin

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12
Q

What drugs end in Capone, used to treat Parkinson’s, only 20% effective, must combine with other drugs

A

Comt inhibitors

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13
Q

Serotonin agonist, used for GERD, blocks P450, lethal arrhythmias

A

Cisapride

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14
Q

2 drugs used to treat migraines, taken off market, first caused strokes/MI’s, second causes above plus retroperitoneal fibrosis

A

Methysergide

Tergesteride

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15
Q

Serotonin agonist and DA blocker, caused Parkinson’s in patients taking drug for long time?

A

Metoclopramide

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16
Q

Alpha 1 agonist, DOC for anaphylaxis?

A

Epinephrine

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17
Q

Alpha 1 agonist, most common decongestant?

A

Ephedrine

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18
Q

Alpha 1 agonist, DOC for neurogenic shock?

A

Phenlyephrine

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19
Q

Alpha 1 antagonist, used to diagnose pheochromocytoma?

A

Phentolamine

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20
Q

Alpha 1 antagonist, DOC for pheochromocytoma?

A

Phenoxybenzamine

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21
Q

Alpha 1 antagonist, DOC for ED before viagra?

A

Yohimbe

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22
Q

Alpha 1 antagonist, used for hypertension, first dose syncope?

A

Prazosin

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23
Q

Alpha 1 antagonist, first line for BPH?

A

Terazosin

Doxazosin

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24
Q

Alpha 1 antagonist, has fewest side effects in this class?

A

Tamsulosin

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25
Q

Blocks reuptake of catecholamines?

A

Cocaine

TCA’s

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26
Q

Promotes the release of catecholamines?

A

Amphetamines

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27
Q

Treatment for amphetamine over dose?

A

Ammonium chloride

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28
Q

Alpha 2 agonist, used in behavioral problems and hypertension, SE: rebound hypertension?

A

Clonidine

29
Q

Alpha 2 agonist,DOC for hypertension in pregnant female? SE- HA

A

Alpha Methyldopa

30
Q

Beta 2 agonists, 60% beta 2 40% beta 1, used in asthmatics to cause bronchodilation, SE- tachycardia?

A

Isoproterenol
Levoproterenol
Metaproterenol

31
Q

Beta 2 agonists, first line in asthma and COPD?

A

Albuterol

Terbutaline

32
Q

Beta 2 agonist used in preterm labor?

A

Terbutaline

Ritodrine

33
Q

Beta 2 agonists, long acting, usually combined with steroid for progressive asthma symptoms?

A

Salmeterol

Fometerol

34
Q

Specific beta 1 blockers start with?

A

A-M (not including L or C)

35
Q

beta blockers start with N-Z (including L and C)?

A

Non-specific beta blockers

36
Q

Beta blocker, longest acting?

A

Propranolol

37
Q

Beta blocker, shortest acting, used by anesthesiologists?

A

Esmolol

38
Q

Beta blocker, used in open angle glaucoma?

A

Timolol

Betaxolol

39
Q

Beta blocker, blocks potassium channels, widened QT interval?

A

Sotalol

40
Q

Beta blocker, smooth muscle relaxant effects?

A

Nabivolol

41
Q

Alpha 1, beta 1, beta 2 blockers, tx pheochromocytoma, hypertensive crisis when cant use sodium nitroprusside-pregnant?

A

Labetolol

Carvedilol

42
Q

Beta blocker, cardio selective, with intrinsic sympathomimetic activity?

A

Acebutolol

43
Q

Beta blockers, decrease mortality after MI?

A

Carbedilol
Metaprolol
Bisoprolol

44
Q

Dopamine blockers that are for anti-emesis in children? Adults?

A

Promethazine

Perchlorperazine

45
Q

Tx of hypertension, blocks vesiculization of catecholamines?

A

Reserpine

46
Q

Taken up presynaptically, pushes catecholamines out of their vesicles?

A

Guanethidine

47
Q

Used for copper and lead poisoning, blocks everything with a 2+ charge?

A

Penicillamine

48
Q

Used to treat lead and arsenic poisoning?

A

Dimercaprol (BAL)

49
Q

Chelator that is used for lead poisoning?

A

EDTA

50
Q

Blocks the SNARES from binding the presynaptic terminal, cannot release neurotransmitter?

A

Botulin toxin

51
Q

Cardio selective calcium channel blockers?

A

Verapamil

Diltiazem

52
Q

Decreases vasospasm after subarachnoid hemorrhage, decreases mortality?

A

Nimodipine

53
Q

Calcium channel blockers

A 
Verapamil
Diltiazem
Nimodipine
Nicardipine
Femlodipine
Amlodipine
54
Q

Acute MI Tx?

A 
O2
Aspirin
Nitrate
Heparin
Morphine
Tpa
B-blocker
Ace inhibitor
Stop metformin/ Ca2+ channel blocker
55
Q

Beta 1 agonist raise heart rate and contractility?

A

Dobutamine

56
Q

Bind D1 receptors, dilate blood vessels in the kidney/GI, bind Beta 1 receptors causing increase in heart rate/contractility?

A 
Dopamine 
Feldopam
(Low dose)
57
Q

Blocks the Na/K pump by competing with K?

A

Digitalis

58
Q

Tx of digitalis toxicity?

A

Digibind

Digifab

59
Q

Aldosterone blockers that decrease mortality in HF?

A

Spirinolactone

Eplerenone

60
Q

Decreases mortality in blacks with HF?

A

Nitric oxide

61
Q

ADH blockers?

A

Conavaptan

Tolvaptan

62
Q

Acetylcholine esterase inhibitor, used for diagnosis of MG, short acting, reversible?

A

Edrophonium

63
Q

Acetylcholine esterase inhibitor, First line tx for MG? 2nd line, reversible?

A

Neostigmine
Pyridostigmine
(Don’t use physostigmine because of too many CNS side effects)

64
Q

Acetylcholine esterase inhibitors, irreversible end in what?

A

Thion (malathion, nalathion, parathion)

Phate (diflorophate, echothiophate)

65
Q

Doc for tx of organophosphate poisoning?

A

Atropine
Then
Pralidoxime (2-PAM)

66
Q

DOC for heart block, to dry pulmonary secretions before surgery and cholinergic crisis?

A

Atropine

67
Q

Also can be used to dry up pulmonary secretions before surgery?

A

Glycopyrollate

68
Q

Used in Parkinson’s for dystonia?

A

Benztropine

69
Q

Mucolytics used in COPD to dry up secretions?

A

Guanefesin

N-acetylcystiene

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