Neuropharmacology Flashcards
(28 cards)
What are the six steps of adrenergic transmission
NE synthesis
Vesicle uptake of NT
Release of NT
Receptor interactions
Reuptake
metabolism
What is the major mechanism of termination of action of adrenergic transmission
reuptake
What are the three types of adrenergic receptors
alpha, beta, dopamine
What are the prominent effector organs/locations of alpha 1 receptors
arterioles, veins, uterus
What is the response to alpha 1 receptor activation
increase Ca2+ and contraction
What will the response be to an alpha 2 receptor being activated
inhibition of NE release at the presynaptic nerve ending
decrease in sympathetic tone in CNS
Which adrenergic receptor is associated with the heart primarily
Beta 1
What two adrenergic receptors have opposing affects on arterioles and uterine smooth muscle
alpha 1 and beta 2
What adrenergic receptor is associated with lipocytes?
B3
What receptor is the main modulator of BP?
alpha1
Which receptor will have a greater affect on blood pressure alpha 1 or beta 2
alpha 1
What are the adrenergic agonist effects on blood pressure
increased by alpha1
decreased by alpha 2 and beta 2
indirectly increased by beta1
What are the adrenergic agonist effects on the heart
increase contraction by activation of beta1
What are the adrenergic agonist effects on the smooth muscle of the GI tract
decrease in motility by alpha2 and beta 2
increased sphincter contraction by alpha1
What are the adrenergic agonist effects on the urinary bladder
contraction of internal sphincter by alpha 1
relaxation of the fundus by beta 2
What are the adrenergic agonist effects on the bronchioles
relaxation
What are the adrenergic agonist effects on the eye
mydriasis
decreased intraocular pressure
What are the adrenergic agonist effects on metabolism
increase blood glucose (beta2)
decrease insulin secreation (alpha2)
stimulate glucagon secretion (beta 2)
What are some clinical applications of adrenergic agonist?
- anaphylactic shock/hypersensitivity rxns
2.Congestive heart failure - AV block
- Cardiac & septic shock
- cardiac arrest
6.local hemostatic agents - prolong local anesthetic effects
- nasal decongestants
9.urinary bladder sphincter incompetence - brinchodilator
- open angel glaucoma
- sedation
What are the adrenergic alpha antagonist effects on the cardiovascular system
decreases blood pressure
What are the adrenergic alpha antagonist effects on the eye
miosis
What are the adrenergic alpha antagonist effects on the bladder
relaxation of sphincter
What are the adrenergic beta antagonist effects on cardiovascular system
decrease in all of the things
What are the adrenergic beta antagonist effects on the resp system
bronchoconstriction
