NME 2.7 Flashcards
1
Q
hepatic function?
A
- digestion
- metabolism
- protein synthesis
- detoxification
2
Q
what does liver store
A
- copper
- iron
- fat soluble vitamins
3
Q
role of liver in energy metabolism?
A
- orchestrates fasting and feeding changes
- gluconeogenesis
- synthesis of triglyceride and cholestrol
- cholestrol excretion
- ketone bodies from fatty acids
4
Q
what proteins does the liver biosynthesize?
A
- albumin
- alpha fetoprotein
- plasma fibronectin
- c-reactive protein
- alpha-microglobulin
5
Q
what are the carriage or transport proteins?
A
- apolipoproteins
- tranferrin
- caerulplasmin
- transcortin
- sex hormone binding globulin
- orosomucoid
- albumin
- thyroid hormone binding
- retinol binding protein
- transcalciferin
6
Q
what are the coagulation factors?
A
- fibrinogen and all factors except VIII
7
Q
what is the coagulation inhibitors
A
- alpha - 1 anto trypsin
- anti-thrombin III
8
Q
what are fibrinolysis inhibitors
A
- alpha - 2 antiplasmin
9
Q
what does detoxification
A
- make substances more polar so water soluble
- excreted into bile
10
Q
what is phase I?
A
- metabolism
11
Q
what is phase II?
A
- conjugation
12
Q
what is phase III?
A
- secretion
13
Q
what happens in phase I?
A
- oxidise through metabolism
- reduction
- hydrolysis
- cytochrome P450
- makes it more polar and water soluble
14
Q
what happens in phase II?
A
- conjugation will link it with a conjugate
15
Q
what is cytochrome P450?
A
- they are involved in specific processes
- important for adverse drug reaction
- some individuals will be able to have high ability to metabolise the drug
