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Therapeutics 2 Drugs - Fall 2018 > Non-insulin medications > Flashcards

Non-insulin medications Flashcards

Classification, dosing, AE and CI

1
Q

Name the DPP-IV

A 
"gliptins" 
Sita
Saxa
Lina
Alo
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2
Q

Dosing for Sitagliptin

A

CrCl >50 100mgd
CrCl 30-50 50mgd
CrCl <30 25mgd

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3
Q

Dosing for Saxagliptin

A

CrCl >50 2.5-5mgd

CrCl <50 2.5mgd

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4
Q

Dosing for Linagliptin

A

5mgd

NO RENAL ADJUSTMENT

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5
Q

Dosing for Alogliptin

A

CrCL >60 25mgd
CrCL 30-60 12.5mgd
CrCL <30 6.25mgd

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6
Q

Dosing for Metformin

A

Initial: 500mg BID or 825mg d
Max 2g/d
CrCl >60 monitor SrCl annually
CrCl 45-60 Monitor SrCl q3-6m
CrCl 30-45 reduced dose by 50% do not start therapy
CrCl <30 Do not start therapy. D/C if already on therapy

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7
Q

Name the SGLT-2 inhibitors

A 
"flozins" 
Cana
Dapa
Empagla
Ertugl
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8
Q

Dosing for Canagliflozin

A

CrCl >60 100mgd- 300mgd
CrCl 45-60 100mgd MAX
CrCl <45 DO NOT USE

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9
Q

Dosing for Dapagliflozin

A

CrCl >60 5mgd

CrCl <60 DO NOT USE

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10
Q

Dosing for Empagliflozin

A

CrCl >45 10mgd- 25mgd

CrCl <45 DO NOT USe

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11
Q

Dosing for Ertugliflozin

A

CrCl > 60 5mg-15mgd

CrCl < 60 DO NOT USE

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12
Q

Dosing for Sulfonylureas

A

“ides”
Glipi
Glybur
Glime

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13
Q

Dosing for Glimepride

A

1-2 mgd

Max 8mg

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14
Q

Dosing for Glyburide

A

1.25- 5mgd
Max 20mg

Micronized: 1.25- 5mgd
Max 12mg

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15
Q

Dosing for Glipizide

A

2.5-5mgd
Max 40mg

XL: 2.5-5mgd
Max 20mg

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16
Q

Name the GLP-1 Agonists

A 
"tides" 
Sema
Lira
Dula
Lixi
Exena
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17
Q

Dosing for Semaglutide

A
  1. 25mg Sq x 4 weeks once weekly

0. 5mg Sq or 1 mg once weekly

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18
Q

Dosing for Exenatide

A

Take 60min before meals!

Short-acting:
5mcg SQ BID x 1 month
10mcg SQ BID

Long-acting:
2mg SQ once weekly

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19
Q

Dosing for Dulaglutide

A

0.75-1.5mg SQ weekly

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20
Q

Dosing for Liraglutide

A
  1. 6mg SQ once a day x 7 days

1. 8mg SQ once a day

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21
Q

Dosing for Lixisenatide

A

10mcg SQ x 2 weeks daily

20mcg SQ

22
Q

Name the Meglitinides

A

“glinides”
Repa
Nate

23
Q

Dosing for Repaglinide

A

A1C > 8% 1-2mg with food
A1C < 8% 0.5mg with food
Max 6mgd

24
Q

Dosing for Nateglinide

A

A1C > 8% 120mg with food
A1C < 8% 60mg with food
Max 360mgd

25
Q

Name the Thiazolidinediones

A

“zones”
Pio
Rosi

26
Q

Dosing for pioglitazone

A

initial: 15-30mgd
Max: 30-45mgd

27
Q

Dosing for Rosiglitazone

A

initial: 4mgd
Max: 8mgd

28
Q

Name the Amylin mimetic

A

Pramlintide

29
Q

Dosing for Pramlintide

A

Take before meal!

T1DM
15mcg–> titrate by 15mcg to 30-60mcg

T1DM
60mcg–> titrate to 120mcg

30
Q

AE of metformin

A

GI- N/V/D
Vit B12 deficiency
LA

31
Q

AE in GLP-1

A

Dose-dependent N/V
Hypoglycemia
Pancreatitis
Thyroid Cancer risk

32
Q

AE in DPP-IV

A

Pancreatitis
Nasopharyngitis
Headache
Upper respiratory infections

33
Q

AE in SGLT-2

A 
UTI
Yeast infections
Increased urination
hypoglycemia
hyperkalemia
increase in cholesterol
34
Q

AE in Sulfonylureas

A 
Hypoglycemia
Weight gain
GI upset
Allergic skin reaction
Hematologic
35
Q

AE in Thiazolidinediones

A

Hepatotoxicity
Exacerbations of HF
Macular Edema
Increased fracture risk

36
Q

AE in Meglitinides

A

Hypoglycemia

Weight gain

37
Q

AE in Alpha-glucosidase inhibitors

A

GI upset
Rashes
Increased liver function tests

38
Q

AE in Amylin mimetics

A

Severe hypoglycemia when used with insulin
N/V
Anorexia

39
Q

AE in Insulin

A 
Weight gain
Hypoglycemia 
Lipodystrophy
Lipoatrophy
Insulin resistance
40
Q

CI in HF (III-IV)

A

Metformin
DPP-IV
Caution with TZDs

41
Q

CI in Kidney Disease

A 
Metformin
     CrCl < 30
Canagliflozin 
     CrCl < 45
Dapaflozin
     CrCl < 60
Empagliflozin
     CrCl <45
Ertugliflozin
     CrCl <60
Caution in sulfonylureas
42
Q

CI in fracture risk

A

Canagliflozin

TZDs

43
Q

CI in pancreatitis

A

DPP-IV

GLP-1

44
Q

CI in liver disease

A

TZDs

Caution with: meglitinides and Sulfonylureas

45
Q

CI in joint pain

A

DPP-IV

46
Q

CI in Thyroid Cancer hx or FH

A

GLP-1

47
Q

CI in GI disorders

A

Alpha-glucosidase

48
Q

CI in alcoholism

A

Caution with metformin and sulfonylureas

49
Q

CI in Age

A

Caution with: Metformin, sulfonylureas, and meglitinides

50
Q

CI in DKA

A

Metformin
Meglitinides
Caution with SGLT-2

Therapeutics 2 Drugs - Fall 2018 (5 decks)

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