Nonsterile Compounding Flashcards
(20 cards)
Commercially available suspending agents
Ora-plus: Composed of a gel-like structure that keeps drug particles suspended and prevents settling. Slightly acidic to prevent drug degradation through oxidation. Bland taste - must be combined with Ora-Sweet for flavor.
Ora-Sweet: Similar to simple syrup. Provides flavor to Ora-Plus
Ora-Blend is a combo of Ora-Plus and Ora-Sweet
Binders (4 items)
Acacia
Starch paste
Sucrose syrup
Compressible sugar
Diluents and fillers (12 items)
Tablets/Capsules:
Lactulose
Mannitol
Sorbitol
Starches
Calcium salts
Cellulose powder
Liquids
Water
Glycerin
Alcohol
Topicals
Petrolatum
Mineral oil
Lanolin
Disintegrants (3 items)
Alginic acid
Cellulose products
Starches
Flavorings and coloring agents (9 items)
Non-caloric artificial sweeteners (Aspartame, saccharin, sucralose)
Glycerin
Dextrose
Sugar alcohols (mannitol, sorbitol, xylitol)
Stevia
D&C Red No. 3
Yellow No. 6
Caramel
Ferric oxide (red)
Lubricants (5 items)
Magnesium stearate, calcium stearate, stearic acid
PEG
Glycerin
Mineral oil
Talc
Preservatives (8 items)
Chlorhexidine
Povidone iodine
Sodium benzoate/benzoic acid, benzalkonium chloride, benzyl alcohol
Sorbic acid/potassium sorbate
Methyl/ethyl/propyl parabens
EDTA
Thimerosal
Cetylpyridinium chloride
Anti-foaming agents (2 items)
Simethicone, dimethicone
Buffers (8 items)
Hydrochloric acid
Acetic acid/sodium acetate
Citric acid/sodium citrate
Sodium hydroxide
Boric acid/sodium borate
Sodium bicarbonate/sodium bicarbonate
Sodium biphosphate/sodium phosphate
Potassium phosphate/metaphosphate
Adsorbents (2 items)
Magnesium oxide/carbonate, kaolin
Coatings (regular) (4 items)
Shellac, gelatin, gluten
Cellulose acetate phthalate
Gelling (thickening) agents
Agar, alginates, various gums [guar, xanthan, acacia (a natural gum)], gelatins, bentonite, cellulose, starches, cetyl alcohol, magnesium aluminum silicilate, poloxamer (pluronic) gels, polyvinyl alcohol, sorbitol
Humectants (5 items)
Glycerin or glycerol, propylene glycol, PEG, lecithin, hyaluronic acid
BUD for non-preserved aqueous dosage forms
14 days, store in refrigerator
BUD for preserved aqueous dosage forms
35 days
BUD for oral non-aqueous liquids
90 days
BUD for other non-aqueous dosage forms
180 days
What is the master formulation record?
The recipe that is followed to compound a preparation
What is the compounding record?
The log book of all products made at the pharmacy
Minimum weighable quantity
sensitivity requirement/acceptable error rate (0.05 or 5%)
