Renal Disease

Question 1

Key drugs that cause nephrotoxicity (10 drugs)

Answer 1

Aminoglycosides
Amphotericin B
Cisplatin
Cyclosporine
Loop diuretics
NSAIDs
Polymyxins
Radiographic contrast dye
Tacrolimus
Vancomycin

Question 2

Key drugs that require a decreased dose or increased interval in CKD (13 drugs)

Answer 2

Aminoglycosides (Increase dosing interval)
Beta-lactam antibiotics (except nafcillin, oxacillin, and ceftriaxone)
Fluconazole
Quinolones (except moxifloxacin)
Vancomycin
LMWHs (enoxaparin)
Rivaroxaban* (for AF)
Apixaban* (for AF)
Dabigatran* (for AF)
H2RAs (famotidine, ranitadine)
Metoclopramide
Bisphosphonates
Lithium

Question 3

Key drugs that are contraindicated in CKD (10 drugs)

Answer 3

CrCl < 60 mL/min: Nitrofurantoin
CrCl < 50 ml/min: Tenofovir disoproxil fumarate containing products, voriconazole IV
CrCl < 30 mL/min: Tenofovir alafenamide containing products, NSAIDs, Dabigatran *(for DVT/PE)
eGFR < 30 mL/min/1.73m^2: Metformin
Other: Meperidine, rivaroxaban, SGLTis

Question 4

Key drugs that raise potassium levels (10 drugs)

Answer 4

ACE inhibitors
Aliskiren
ARBs
Canagliflozin
Drospirenone-containing COCs
Potassium-containing IV fluids
Potassium-sparing diuretics
Potassium supplements
Sulfamethoxazole/trimethoprim
Transplant drugs (cyclosporine, tacrolimus)