Sickle Cell Disease

Question 1

Sickle cell disease ACUTE complications (9)

Answer 1

Acute chest syndrome
Anemia
Cholecystitis
Infection
Multiorgan failure
Priapism
Splenic sequestration
Stroke
Vaso-occlusive crisis

Question 2

Sickle cell disease CHRONIC complications (10)

Answer 2

Avascular necrosis (bone death)
Depression and stress
Gallstones
Leg ulcers
Pain
Pregnancy complications (including fetal death)
Pulmonary hypertension
Recurrent priapism
Renal impairment
Retinopathy

Question 3

Key vaccines in sickle cell disease

Answer 3

Routine childhood series:
Hib
PCV15 or PCV20
Additional vaccines for functional asplenia:
Men ACWY plus Menveo, MenQuadfi
MenB (Bexsero, Trumenba)
If not received as a child, admin either PCV20 or PCV15 plus PPSV23 at least 8 weeks later