NSAIDs Flashcards
(39 cards)
Propionic acid derivatives
ibuprofen
naproxen
Ibuprofen/naproxen uses
- analgesic
- anti-pyretic
- anti-inflammatory
- fewer side effects than aspirin, less toxic
Ibuprofen/naproxen inhibition
reversible and competitive only
ibuprofen/naproxen has specific approval for what?
dysmenorrhea
Adverse effects of ibuprofen/naproxen
- GI similar to aspirin (less severe, more potent, lower dose)
- prolong bleeding (short term)
- high albumin binding
- cross sensitivity
- prevent low dose aspirin from exerting anti-platelet effects
ibuprofen/naproxen is ___% protein binding
98%
Ibuprofen/naproxen and aspirin
take 8 hr before or 30 min after taking low dose aspirin
All NSAIDs can cause what?
renal toxicity/failure
Ibuprofen/naproxen toxicity
- tinnitus
- N/V
- GI bleeding
- lethargy
- seizures
- coma
Treatment of OD ibuprofen/naproxen
- activated charcoal first 2 hr
- supportive therapy
- monitor respirations
- urine alkalization not effective! (because protein bound)
Low dose ibuprofen use
analgesia/anti-pyresis
high dose ibuprofen use
anti-inflammatory
Ibuprofen specifically approved for
patent ductus arteriosus
Naproxen additional approvals
Gout
migraine
Acetic acid derivatives
indomethacin
Indomethacin is ___ more potent than aspirin
10-20x
indomethacin use
- limited use for analgesia and antipyresis
- Severe inflammation (RA, gouty arthritis)
indomethacin side effects
- severe HA, vertigo, confusion
- seizures
- serious GI problems
Selective COX2 inhibitor
Celecoxib
Most inflammation effects are due to ___
COX2
Celecoxib is equal to naproxen for what?
osteoarthritis and RA
Celecoxib is poorer than naproxen for what?
acute pain
DI celecoxib
- may inhibit CYP2D6
- slow metabolism of tricyclic and SSRI
Adverse effects of celecoxib
- edema
- GI (less than with ibu/nap)
- increased risk of MI
