Nucleic Acid Disrupters Flashcards
1
Q
Daptomycin MOA
A
- Ca2+ insertion of lipophilic tail into PM
- channel permits efflux of K
- membrane depolarizatio
2
Q
Daptomycin bactericidal or bacteriostatic?
A
bactericidal
3
Q
Daptomycin G+ or G-?
A
G+
4
Q
Daptomycin administered
A
IV, not IM
5
Q
Daptomycin use
A
- Resistant G+ s/s tissue infections (MRSA, strep, VRE)
- endocarditis, bacteremia
6
Q
Daptomycin adverse reactions
A
- myopathy
- eosinophilic pneumonia
7
Q
Colistin MOA
A
- bind (-) LPS in G- bacteria
- detergent like effect
8
Q
Colistin sulfate cationic or anionic?
A
cationic
9
Q
Colistin sulfate use
A
topical and oral GI use
10
Q
Colistimethate cationic or anionic?
A
anionic
11
Q
Colistimethate use
A
parenteral
prodrug
- serious MDR G- bacterial infections
- ESKAPE pathogens
12
Q
Colistin adverse reactions
A
- only with parenteral use
- nephrotoxicity (serious, but reversible)
- neurotoxicity (NMJ, weakness, apnea)
